Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about MAPK/ERK: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | MAPK/ERK |
| Summary | Page for MAPK/ERK Signaling Pathway in Neurodegeneration |
| Key Genes/Proteins | TARDBP, NPY, EGR1, SQSTM1/p62, integrins, Trk-B |
| Related Diseases | reduced loading |
| Related Pathways | autophagy |
Knowledge base pages for this entity
graph TD
MAPK_ERK["MAPK/ERK"]
MAPK_ERK -->|"activates"| EGR1["EGR1"]
MAPK_ERK -->|"promotes"| neurodegeneration["neurodegeneration"]
autophagy["autophagy"] -->|"activates"| MAPK_ERK
SQSTM1_p62["SQSTM1/p62"] -->|"inhibits"| MAPK_ERK
integrins["integrins"] -->|"activates"| MAPK_ERK
reduced_loading["reduced loading"] -->|"inhibits"| MAPK_ERK
ERK["ERK"] -->|"activates"| MAPK_ERK
MAPK["MAPK"] -->|"activates"| MAPK_ERK
AUTOPHAGY["AUTOPHAGY"] -->|"activates"| MAPK_ERK
AKT["AKT"] -->|"inhibits"| MAPK_ERK| Target | Relation | Type | Str |
|---|---|---|---|
| TARDBP | phosphorylates | protein | 0.95 |
| EGR1 | activates | protein | 0.90 |
| neurodegeneration | promotes | process | 0.80 |
| Trk-B | activates | gene | 0.80 |
| Source | Relation | Type | Str |
|---|---|---|---|
| NPY | activates | protein | 0.95 |
| autophagy | activates | pathway | 0.90 |
| SQSTM1/p62 | inhibits | protein | 0.90 |
| integrins | activates | protein | 0.85 |
| Heat Shock Response | activates | process | 0.85 |
| reduced loading | inhibits | phenotype | 0.80 |
| BDNF | activates | protein | 0.80 |
| ERK | activates | gene | 0.50 |
| MAPK | activates | gene | 0.50 |
| AUTOPHAGY | activates | process | 0.50 |
| AKT | inhibits | gene | 0.50 |
| PI3K | inhibits | gene | 0.50 |
| ERBB2 | inhibits | gene | 0.50 |
| RAS | inhibits | gene | 0.50 |
| ERK | inhibits | gene | 0.50 |
| MAPK | inhibits | gene | 0.50 |
| PI3K/AKT | inhibits | pathway | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||