Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about HEAT SHOCK RESPONSE: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | HEAT SHOCK RESPONSE |
Knowledge base pages for this entity
graph TD
HEAT_SHOCK_RESPONSE["HEAT SHOCK RESPONSE"]
MIRNAS["MIRNAS"] -->|"regulates"| HEAT_SHOCK_RESPONSE
PKC["PKC"] -->|"regulates"| HEAT_SHOCK_RESPONSE
HSP27["HSP27"] -->|"regulates"| HEAT_SHOCK_RESPONSE
APOPTOSIS["APOPTOSIS"] -->|"regulates"| HEAT_SHOCK_RESPONSE
PI3K["PI3K"] -->|"regulates"| HEAT_SHOCK_RESPONSE
HIF["HIF"] -->|"regulates"| HEAT_SHOCK_RESPONSE
NF__B["NF-KappaB"] -->|"regulates"| HEAT_SHOCK_RESPONSE
HSF1["HSF1"] -->|"regulates"| HEAT_SHOCK_RESPONSE| Target | Relation | Type | Str |
|---|---|---|---|
| TARDBP | phosphorylates | protein | 0.90 |
| Protein Homeostasis | promotes | process | 0.85 |
| MAPK/ERK | activates | pathway | 0.85 |
| Source | Relation | Type | Str |
|---|---|---|---|
| PKC | regulates | gene | 0.60 |
| HSP27 | regulates | gene | 0.60 |
| PI3K | regulates | gene | 0.60 |
| HSF1 | regulates | gene | 0.60 |
| HSP70 | regulates | gene | 0.60 |
| AKT | regulates | gene | 0.60 |
| OVERVIEW | regulates | gene | 0.60 |
| MTOR | regulates | gene | 0.60 |
| TDP-43 | activates | gene | 0.60 |
| MIRNAS | regulates | gene | 0.60 |
| APOPTOSIS | regulates | gene | 0.60 |
| HIF | regulates | gene | 0.60 |
| NF-ΚB | regulates | gene | 0.60 |
| CANCER | regulates | gene | 0.60 |
| MICRORNAS | regulates | gene | 0.60 |
| Cancer | regulates | disease | 0.60 |
| RNA | regulates | gene | 0.60 |
| ALZHEIMER | regulates | gene | 0.60 |
| MEK | activates | gene | 0.60 |
| Alzheimer | regulates | disease | 0.55 |
| Aging | regulates | disease | 0.55 |
| Neurodegeneration | regulates | disease | 0.55 |
| Amyotrophic Lateral Sclerosis | regulates | disease | 0.55 |
| Als | regulates | disease | 0.55 |
| Tdp-43 | activates | protein | 0.55 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||