Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about MGA: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | MGA |
| Key Genes/Proteins | TPM2, RAC1, PARKINSON, CDC42, SOD2, GENES |
| Related Diseases | Type 2 Diabetes Mellitus with Parkinson's Disease, Parkinson's Disease, Inflammation, Diabetes, Parkinson |
Knowledge base pages for this entity
graph TD
MGA["MGA"]
MGA -->|"upregulates"| Type_2_Diabetes_Mellitus_with_["Type 2 Diabetes Mellitus with Parkinson's Disease"]
MGA -->|"target for"| Parkinson["Parkinson"]
MGA -->|"target for"| Diabetes["Diabetes"]
MGA -->|"regulates"| TPM2["TPM2"]
MGA -->|"regulates"| RAC1["RAC1"]
MGA -->|"regulates"| GENES["GENES"]
MGA -->|"regulates"| DENND3["DENND3"]
MGA -->|"regulates"| HUB_GENES["HUB GENES"]
DENND3 -->|"regulates"| MGA
NCF1["NCF1"] -->|"target for"| MGA
SOD2["SOD2"] -->|"target for"| MGA
MMP9["MMP9"] -->|"target for"| MGA
PARKINSON["PARKINSON"] -->|"target for"| MGA
RAC1 -->|"regulates"| MGA
VIM["VIM"] -->|"target for"| MGA
MET["MET"] -->|"target for"| MGA| Target | Relation | Type | Str |
|---|---|---|---|
| Type 2 Diabetes Mellitus with Parkinson's Disease | upregulates | disease | 0.80 |
| Parkinson's Disease | associated_with | disease | 0.75 |
| Inflammation | associated_with | disease | 0.65 |
| Diabetes | associated_with | disease | 0.65 |
| Parkinson | associated_with | disease | 0.65 |
| Parkinson | therapeutic_target | disease | 0.65 |
| Diabetes | therapeutic_target | disease | 0.65 |
| TPM2 | regulates | gene | 0.60 |
| RAC1 | regulates | gene | 0.60 |
| PARKINSON | associated_with | gene | 0.60 |
| CDC42 | associated_with | gene | 0.60 |
| SOD2 | associated_with | gene | 0.60 |
| GENES | regulates | gene | 0.60 |
| MMP9 | associated_with | gene | 0.60 |
| INFLAMMATION | associated_with | gene | 0.60 |
| MET | associated_with | gene | 0.60 |
| NCF1 | associated_with | gene | 0.60 |
| DENND3 | regulates | gene | 0.60 |
| Oxidative Stress | associated_with | pathway | 0.60 |
| HUB GENES | regulates | gene | 0.60 |
| VIM | associated_with | gene | 0.60 |
| OXIDATIVE STRESS | associated_with | gene | 0.60 |
| AND | regulates | gene | 0.60 |
| PARKINSON'S DISEASE | associated_with | gene | 0.60 |
| GFAP | associated_with | gene | 0.60 |
| CYCS | associated_with | gene | 0.60 |
| DIABETES MELLITUS | associated_with | gene | 0.60 |
| CDC42 | therapeutic_target | gene | 0.60 |
| CYCS | therapeutic_target | gene | 0.60 |
| VIM | therapeutic_target | gene | 0.60 |
| MET | therapeutic_target | gene | 0.60 |
| GFAP | therapeutic_target | gene | 0.60 |
| Oxidative Stress | therapeutic_target | pathway | 0.60 |
| SOD2 | therapeutic_target | gene | 0.60 |
| PARKINSON | therapeutic_target | gene | 0.60 |
| NCF1 | therapeutic_target | gene | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| TPM2 | associated_with | gene | 0.70 |
| GFAP | associated_with | gene | 0.60 |
| DIABETES MELLITUS | associated_with | gene | 0.60 |
| VIM | associated_with | gene | 0.60 |
| PARKINSON'S DISEASE | associated_with | gene | 0.60 |
| OXIDATIVE STRESS | associated_with | gene | 0.60 |
| CYCS | associated_with | gene | 0.60 |
| DENND3 | regulates | gene | 0.60 |
| NCF1 | therapeutic_target | gene | 0.60 |
| SOD2 | therapeutic_target | gene | 0.60 |
| MMP9 | therapeutic_target | gene | 0.60 |
| PARKINSON | therapeutic_target | gene | 0.60 |
| RAC1 | regulates | gene | 0.60 |
| VIM | therapeutic_target | gene | 0.60 |
| MET | therapeutic_target | gene | 0.60 |
| CDC42 | therapeutic_target | gene | 0.60 |
| TPM2 | regulates | gene | 0.60 |
| GFAP | therapeutic_target | gene | 0.60 |
| CYCS | therapeutic_target | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||