TPM2

Understanding Entity Pages

This page aggregates everything SciDEX knows about TPM2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

TPM2 is a gene implicated in neurodegeneration research. Key relationships include: associated with, therapeutic target, regulates. Associated with Diabetes, Inflammation, Ms. Connected to 60 entities in the SciDEX knowledge graph.

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graph TD
    TPM2["<b>TPM2</b>"]
    NEFL["NEFL"]
    TPM2 -->|"binds"| NEFL
    INA["INA"]
    TPM2 -->|"binds"| INA
    GIG["GIG"]
    TPM2 -->|"binds"| GIG
    ELANE["ELANE"]
    TPM2 -->|"regulates"| ELANE
    IL1B["IL1B"]
    TPM2 -->|"regulates"| IL1B
    IL8["IL8"]
    TPM2 -->|"regulates"| IL8
    RAC1["RAC1"]
    TPM2 -->|"associated with"| RAC1
    MGA["MGA"]
    TPM2 -->|"associated with"| MGA
    DENND3["DENND3"]
    TPM2 -->|"associated with"| DENND3
    Inflammation{"Inflammation"}
    TPM2 -->|"therapeutic target"| Inflammation
    Ms{"Ms"}
    TPM2 -->|"therapeutic target"| Ms
    Parkinson{"Parkinson"}
    TPM2 -->|"therapeutic target"| Parkinson
    SOD2["SOD2"]
    SOD2 -->|"therapeutic target"| TPM2
    CDC42["CDC42"]
    CDC42 -->|"therapeutic target"| TPM2
    CYCS["CYCS"]
    CYCS -->|"therapeutic target"| TPM2
    GFAP["GFAP"]
    GFAP -->|"therapeutic target"| TPM2
    RAC1 -->|"regulates"| TPM2
    MET["MET"]
    MET -->|"therapeutic target"| TPM2
    MMP9["MMP9"]
    MMP9 -->|"therapeutic target"| TPM2
    VIM["VIM"]
    VIM -->|"therapeutic target"| TPM2
    style TPM2 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0