Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about NDEL1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
NDEL1 is a gene implicated in neurodegeneration research. Key relationships include: expressed in, interacts with, therapeutic target. Associated with Aging, Als, Ms. Connected to 27 entities in the SciDEX knowledge graph.
| Gene Symbol | NDEL1 |
| Full Name | Nudel Homolog 1 (Drosophila) |
| Chromosome | 16p13.3 |
| Protein Family | NDEL1 family (NDE1/NDEL1) |
| Function | It functions as a scaffold protein that |
| Primary Expression | Cerebral cortex, Hippocampus, Cerebellum, Fetal brain |
| Molecular Weight | 38 kDa |
| Amino Acids | 347 aa |
| Exons | 14 |
| UniProt ID | Q9GZI8 |
| NCBI Gene ID | 4740 |
| Ensembl ID | ENSG00000132640 |
| OMIM | 607603 |
| GeneCards | NDEL1 |
| Human Protein Atlas | NDEL1 |
| Associated Diseases | Schizophrenia, Bipolar Disorder, Lissencephaly |
| Interactions | LIS1, DISC1, PAFAH1B1 |
| KG Connections | 28 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
NDEL1["<b>NDEL1</b>"]
Als{"Als"}
NDEL1 -->|"expressed in"| Als
Aging{"Aging"}
NDEL1 -->|"expressed in"| Aging
Ms{"Ms"}
NDEL1 -->|"expressed in"| Ms
Schizophrenia{"Schizophrenia"}
NDEL1 -->|"expressed in"| Schizophrenia
NDEL1 -->|"regulates"| Als
NDEL1 -->|"interacts with"| Ms
NDEL1 -->|"interacts with"| Schizophrenia
NDEL1 -->|"therapeutic target"| Als
FKBP5["FKBP5"]
NDEL1 -->|"expressed in"| FKBP5
Epigenetic(["Epigenetic"])
NDEL1 -->|"expressed in"| Epigenetic
Akt(["Akt"])
NDEL1 -->|"expressed in"| Akt
DISC1["DISC1"]
NDEL1 -->|"expressed in"| DISC1
SLC6A4["SLC6A4"]
SLC6A4 -->|"expressed in"| NDEL1
IL8["IL8"]
IL8 -->|"expressed in"| NDEL1
DICER1["DICER1"]
DICER1 -->|"expressed in"| NDEL1
NR3C1["NR3C1"]
NR3C1 -->|"expressed in"| NDEL1
IL1B["IL1B"]
IL1B -->|"expressed in"| NDEL1
AKT1["AKT1"]
AKT1 -->|"expressed in"| NDEL1
COMT["COMT"]
COMT -->|"expressed in"| NDEL1
IL_6["IL-6"]
IL_6 -->|"expressed in"| NDEL1
BDNF["BDNF"]
BDNF -->|"expressed in"| NDEL1
DISC1 -->|"expressed in"| NDEL1
GCH1["GCH1"]
GCH1 -->|"expressed in"| NDEL1
style NDEL1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| dynein motor complex | associated_with | protein | 0.80 |
| Als | expressed_in | disease | 0.65 |
| Aging | expressed_in | disease | 0.65 |
| Ms | expressed_in | disease | 0.65 |
| Schizophrenia | expressed_in | disease | 0.65 |
| Als | regulates | disease | 0.65 |
| Ms | interacts_with | disease | 0.65 |
| Schizophrenia | interacts_with | disease | 0.65 |
| Als | therapeutic_target | disease | 0.65 |
| FKBP5 | expressed_in | gene | 0.60 |
| DISC1 | expressed_in | gene | 0.60 |
| LIS1 | interacts_with | gene | 0.60 |
| DISC1 | interacts_with | gene | 0.60 |
| PDE4B | therapeutic_target | gene | 0.60 |
| Epigenetic | expressed_in | pathway | 0.60 |
| Akt | expressed_in | pathway | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| PAFAH1B1 | interacts_with | protein | 0.80 |
| SLC6A4 | expressed_in | gene | 0.60 |
| DICER1 | expressed_in | gene | 0.60 |
| NR3C1 | expressed_in | gene | 0.60 |
| IL1B | expressed_in | gene | 0.60 |
| AKT1 | expressed_in | gene | 0.60 |
| COMT | expressed_in | gene | 0.60 |
| BDNF | expressed_in | gene | 0.60 |
| DISC1 | expressed_in | gene | 0.60 |
| GCH1 | expressed_in | gene | 0.60 |
| IL8 | expressed_in | gene | 0.60 |
| IL-6 | expressed_in | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||