gene

NDEL1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NDEL1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

28Connections
0Hypotheses
0Analyses
16Outgoing
12Incoming

Summary

NDEL1 is a gene implicated in neurodegeneration research. Key relationships include: expressed in, interacts with, therapeutic target. Associated with Aging, Als, Ms. Connected to 27 entities in the SciDEX knowledge graph.

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🧬 Gene Info
Gene SymbolNDEL1
Full NameNudel Homolog 1 (Drosophila)
Chromosome16p13.3
Protein FamilyNDEL1 family (NDE1/NDEL1)
FunctionIt functions as a scaffold protein that
Primary ExpressionCerebral cortex, Hippocampus, Cerebellum, Fetal brain
Molecular Weight38 kDa
Amino Acids347 aa
Exons14
UniProt IDQ9GZI8
NCBI Gene ID4740
Ensembl IDENSG00000132640
OMIM607603
GeneCardsNDEL1
Human Protein AtlasNDEL1
Associated DiseasesSchizophrenia, Bipolar Disorder, Lissencephaly
InteractionsLIS1, DISC1, PAFAH1B1
KG Connections28 knowledge graph edges
DatabasesGeneCardsHPASTRING
🔮 Predicted Structure: NDEL1 — AlphaFold Q9GZI8 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (16)

Knowledge base pages for this entity

Canonical Page

NDEL1 — Nudel Homolog 1

gene · 1602 words

GSK3B (Glycogen Synthase Kinase 3 Beta)

protein · 2976 words

Dynactin Protein

protein · 2956 words

Retrograde Axonal Transport Dysfunction in Neurodegeneration

mechanism · 2905 words

KIF3B — Kinesin Family Member 3B

gene · 2177 words

PDE4B — Phosphodiesterase 4B

gene · 1989 words

Pathway Diagram

graph TD
    NDEL1["<b>NDEL1</b>"]
    Als{"Als"}
    NDEL1 -->|"expressed in"| Als
    Aging{"Aging"}
    NDEL1 -->|"expressed in"| Aging
    Ms{"Ms"}
    NDEL1 -->|"expressed in"| Ms
    Schizophrenia{"Schizophrenia"}
    NDEL1 -->|"expressed in"| Schizophrenia
    NDEL1 -->|"regulates"| Als
    NDEL1 -->|"interacts with"| Ms
    NDEL1 -->|"interacts with"| Schizophrenia
    NDEL1 -->|"therapeutic target"| Als
    FKBP5["FKBP5"]
    NDEL1 -->|"expressed in"| FKBP5
    Epigenetic(["Epigenetic"])
    NDEL1 -->|"expressed in"| Epigenetic
    Akt(["Akt"])
    NDEL1 -->|"expressed in"| Akt
    DISC1["DISC1"]
    NDEL1 -->|"expressed in"| DISC1
    SLC6A4["SLC6A4"]
    SLC6A4 -->|"expressed in"| NDEL1
    IL8["IL8"]
    IL8 -->|"expressed in"| NDEL1
    DICER1["DICER1"]
    DICER1 -->|"expressed in"| NDEL1
    NR3C1["NR3C1"]
    NR3C1 -->|"expressed in"| NDEL1
    IL1B["IL1B"]
    IL1B -->|"expressed in"| NDEL1
    AKT1["AKT1"]
    AKT1 -->|"expressed in"| NDEL1
    COMT["COMT"]
    COMT -->|"expressed in"| NDEL1
    IL_6["IL-6"]
    IL_6 -->|"expressed in"| NDEL1
    BDNF["BDNF"]
    BDNF -->|"expressed in"| NDEL1
    DISC1 -->|"expressed in"| NDEL1
    GCH1["GCH1"]
    GCH1 -->|"expressed in"| NDEL1
    style NDEL1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (16)

TargetRelationTypeStr
dynein motor complexassociated_withprotein0.80
Alsexpressed_indisease0.65
Agingexpressed_indisease0.65
Msexpressed_indisease0.65
Schizophreniaexpressed_indisease0.65

Incoming (12)

SourceRelationTypeStr
PAFAH1B1interacts_withprotein0.80
SLC6A4expressed_ingene0.60
DICER1expressed_ingene0.60
NR3C1expressed_ingene0.60
IL1Bexpressed_ingene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found