gene

DICER1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about DICER1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

45Connections
0Hypotheses
0Analyses
38Outgoing
7Incoming

Summary

DICER1 is a gene implicated in neurodegeneration research. Key relationships include: expressed in, regulates, implicated in. Associated with Als, Lymphoma, Ms. Connected to 25 entities in the SciDEX knowledge graph.

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🧬 Gene Info
Gene SymbolDICER1
Full NameDicer 1, Ribonuclease III
Chromosome14q32.13
Functionis a fundamental gene encoding an essential endoribonuclease for microRNA (miRNA) biogenesis.
Primary Expressionboth cytoplasm and nucleus of neurons - Subcellular distribution: Localized to dendritic compartments, enabling local miRNA processing at synapses
Molecular Weight219 kDa
Exons25
UniProt ID[Q9UPY3](https://www.uniprot.org/uniprot/Q9UPY3)
Ensembl IDENSG00000100697
OMIM604310
GeneCardsDICER1
Human Protein AtlasDICER1
N-terminal DExD/H-box helicase domainInvolved in RNA binding and unwinding
DUF283 domainPlatform for protein-protein interactions
PAZ domainBinds the 3' overhang of pre-miRNA substrates
Associated DiseasesALS
InteractionsProteins
KG Connections45 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Wiki Pages (7)

Knowledge base pages for this entity

Canonical Page

DICER1 Gene

gene · 1055 words

NSUN2 Gene

gene · 3064 words

ADARB1 Protein (Adenosine Deaminase Acting on RNA 1)

protein · 1192 words

AGO1 (Argonaute-1)

gene · 741 words

AGO2 (Argonaute-2)

gene · 660 words

RPA1 Gene

gene · 538 words

Pathway Diagram

graph TD
    DICER1["<b>DICER1</b>"]
    Lymphoma{"Lymphoma"}
    DICER1 -->|"regulates"| Lymphoma
    Ms{"Ms"}
    DICER1 -->|"regulates"| Ms
    Als{"Als"}
    DICER1 -->|"expressed in"| Als
    RPA1["RPA1"]
    DICER1 -->|"regulates"| RPA1
    MICRORNAS["MICRORNAS"]
    DICER1 -->|"regulates"| MICRORNAS
    NR3C1["NR3C1"]
    DICER1 -->|"expressed in"| NR3C1
    IL1B["IL1B"]
    DICER1 -->|"expressed in"| IL1B
    AKT1["AKT1"]
    DICER1 -->|"expressed in"| AKT1
    COMT["COMT"]
    DICER1 -->|"expressed in"| COMT
    IL_6["IL-6"]
    DICER1 -->|"expressed in"| IL_6
    BDNF["BDNF"]
    DICER1 -->|"expressed in"| BDNF
    DISC1["DISC1"]
    DICER1 -->|"expressed in"| DISC1
    MICRORNAS -->|"regulates"| DICER1
    RPA1 -->|"regulates"| DICER1
    DNA["DNA"]
    DNA -->|"regulates"| DICER1
    SLC6A4["SLC6A4"]
    SLC6A4 -->|"expressed in"| DICER1
    IL8["IL8"]
    IL8 -->|"expressed in"| DICER1
    AND["AND"]
    AND -->|"associated with"| DICER1
    style DICER1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (38)

TargetRelationTypeStr
Lymphomaregulatesdisease0.65
Msregulatesdisease0.65
Alsexpressed_indisease0.65
Tumorexpressed_indisease0.65
Cancerexpressed_indisease0.65

Incoming (7)

SourceRelationTypeStr
RPA1regulatesgene0.60
SLC6A4expressed_ingene0.60
MICRORNASregulatesgene0.60
DNAregulatesgene0.60
IL8expressed_ingene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found