Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about DICER1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
DICER1 is a gene implicated in neurodegeneration research. Key relationships include: expressed in, regulates, implicated in. Associated with Als, Lymphoma, Ms. Connected to 25 entities in the SciDEX knowledge graph.
| Gene Symbol | DICER1 |
| Full Name | Dicer 1, Ribonuclease III |
| Chromosome | 14q32.13 |
| Function | is a fundamental gene encoding an essential endoribonuclease for microRNA (miRNA) biogenesis. |
| Primary Expression | both cytoplasm and nucleus of neurons - Subcellular distribution: Localized to dendritic compartments, enabling local miRNA processing at synapses |
| Molecular Weight | 219 kDa |
| Exons | 25 |
| UniProt ID | [Q9UPY3](https://www.uniprot.org/uniprot/Q9UPY3) |
| Ensembl ID | ENSG00000100697 |
| OMIM | 604310 |
| GeneCards | DICER1 |
| Human Protein Atlas | DICER1 |
| N-terminal DExD/H-box helicase domain | Involved in RNA binding and unwinding |
| DUF283 domain | Platform for protein-protein interactions |
| PAZ domain | Binds the 3' overhang of pre-miRNA substrates |
| Associated Diseases | ALS |
| Interactions | Proteins |
| KG Connections | 45 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
DICER1["<b>DICER1</b>"]
Lymphoma{"Lymphoma"}
DICER1 -->|"regulates"| Lymphoma
Ms{"Ms"}
DICER1 -->|"regulates"| Ms
Als{"Als"}
DICER1 -->|"expressed in"| Als
RPA1["RPA1"]
DICER1 -->|"regulates"| RPA1
MICRORNAS["MICRORNAS"]
DICER1 -->|"regulates"| MICRORNAS
NR3C1["NR3C1"]
DICER1 -->|"expressed in"| NR3C1
IL1B["IL1B"]
DICER1 -->|"expressed in"| IL1B
AKT1["AKT1"]
DICER1 -->|"expressed in"| AKT1
COMT["COMT"]
DICER1 -->|"expressed in"| COMT
IL_6["IL-6"]
DICER1 -->|"expressed in"| IL_6
BDNF["BDNF"]
DICER1 -->|"expressed in"| BDNF
DISC1["DISC1"]
DICER1 -->|"expressed in"| DISC1
MICRORNAS -->|"regulates"| DICER1
RPA1 -->|"regulates"| DICER1
DNA["DNA"]
DNA -->|"regulates"| DICER1
SLC6A4["SLC6A4"]
SLC6A4 -->|"expressed in"| DICER1
IL8["IL8"]
IL8 -->|"expressed in"| DICER1
AND["AND"]
AND -->|"associated with"| DICER1
style DICER1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Lymphoma | regulates | disease | 0.65 |
| Ms | regulates | disease | 0.65 |
| Als | expressed_in | disease | 0.65 |
| Tumor | expressed_in | disease | 0.65 |
| Cancer | expressed_in | disease | 0.65 |
| ALS | expressed_in | disease | 0.65 |
| Carcinoma | expressed_in | disease | 0.65 |
| RPA1 | regulates | gene | 0.60 |
| NR3C1 | expressed_in | gene | 0.60 |
| IL1B | expressed_in | gene | 0.60 |
| AKT1 | expressed_in | gene | 0.60 |
| COMT | expressed_in | gene | 0.60 |
| BDNF | expressed_in | gene | 0.60 |
| DISC1 | expressed_in | gene | 0.60 |
| GCH1 | expressed_in | gene | 0.60 |
| NDEL1 | expressed_in | gene | 0.60 |
| FKBP5 | expressed_in | gene | 0.60 |
| Rb | expressed_in | protein | 0.60 |
| MICRORNAS | regulates | gene | 0.60 |
| IL-6 | expressed_in | gene | 0.60 |
| Epigenetic | expressed_in | pathway | 0.60 |
| Akt | expressed_in | pathway | 0.60 |
| DNA | regulates | gene | 0.60 |
| AND | associated_with | gene | 0.60 |
| AND | expressed_in | gene | 0.60 |
| CANCER | expressed_in | gene | 0.60 |
| App | expressed_in | protein | 0.60 |
| glioblastoma | expressed_in | disease | 0.60 |
| ALS | associated_with | disease | 0.60 |
| B Cell | expressed_in | cell_type | 0.55 |
| cancer | expressed_in | disease | 0.50 |
| RPA1 | co_expressed_with | gene | 0.50 |
| B Cell | interacts_with | cell_type | 0.50 |
| Microrna | interacts_with | pathway | 0.50 |
| Proteins | interacts_with | protein | 0.50 |
| B CELLS | interacts_with | concept | 0.50 |
| TUMOR | expressed_in | disease | 0.50 |
| CARCINOMA | expressed_in | disease | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||