gene

DICER1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about DICER1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

44Connections

0Hypotheses

2Analyses

38Outgoing

6Incoming

0Experiments

2Debates

Summary

DICER1 is a gene implicated in neurodegeneration research. Key relationships include: expressed in, regulates, implicated in. Associated with Als, Lymphoma, Ms. Connected to 25 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	DICER1
Full Name	Dicer 1, Ribonuclease III
Chromosome	14q32.13
Function	is a fundamental gene encoding an essential endoribonuclease for microRNA (miRNA) biogenesis.
Primary Expression	both cytoplasm and nucleus of neurons - Subcellular distribution: Localized to dendritic compartments, enabling local miRNA processing at synapses
Molecular Weight	219 kDa
Exons	25
UniProt ID	[Q9UPY3](https://www.uniprot.org/uniprot/Q9UPY3)
Ensembl ID	ENSG00000100697
OMIM	604310
GeneCards	DICER1
Human Protein Atlas	DICER1
N-terminal DExD/H-box helicase domain	Involved in RNA binding and unwinding
DUF283 domain	Platform for protein-protein interactions
PAZ domain	Binds the 3' overhang of pre-miRNA substrates
Associated Diseases	ALS
Interactions	Proteins
KG Connections	44 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

DICER1 Gene

gene · 1055 words

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Pathway Diagram

graph TD
    DICER1["DICER1"]
    Lymphoma{"Lymphoma"}
    DICER1 -->|"regulates"| Lymphoma
    Ms{"Ms"}
    DICER1 -->|"regulates"| Ms
    Als{"Als"}
    DICER1 -->|"expressed in"| Als
    RPA1["RPA1"]
    DICER1 -->|"regulates"| RPA1
    MICRORNAS["MICRORNAS"]
    DICER1 -->|"regulates"| MICRORNAS
    NR3C1["NR3C1"]
    DICER1 -->|"expressed in"| NR3C1
    IL1B["IL1B"]
    DICER1 -->|"expressed in"| IL1B
    AKT1["AKT1"]
    DICER1 -->|"expressed in"| AKT1
    COMT["COMT"]
    DICER1 -->|"expressed in"| COMT
    IL_6["IL-6"]
    DICER1 -->|"expressed in"| IL_6
    BDNF["BDNF"]
    DICER1 -->|"expressed in"| BDNF
    DISC1["DISC1"]
    DICER1 -->|"expressed in"| DISC1
    MICRORNAS -->|"regulates"| DICER1
    RPA1 -->|"regulates"| DICER1
    DNA["DNA"]
    DNA -->|"regulates"| DICER1
    SLC6A4["SLC6A4"]
    SLC6A4 -->|"expressed in"| DICER1
    IL8["IL8"]
    IL8 -->|"expressed in"| DICER1
    AND["AND"]
    AND -->|"associated with"| DICER1
    style DICER1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (38)

Target	Relation	Type	Str
GBA intron dsRNA	processes_into_siRNA	RNA	0.00
miRNA_processing	associated_with	pathway	0.90
Als	expressed_in	disease	0.65
Tumor	expressed_in	disease	0.65
Cancer	expressed_in	disease	0.65
ALS	expressed_in	disease	0.65
Carcinoma	expressed_in	disease	0.65
Lymphoma	regulates	disease	0.65
Ms	regulates	disease	0.65
Epigenetic	expressed_in	pathway	0.60
MICRORNAS	regulates	gene	0.60
DNA	regulates	gene	0.60
App	expressed_in	protein	0.60
ALS	associated_with	disease	0.60
Akt	expressed_in	pathway	0.60
IL-6	expressed_in	gene	0.60
IL1B	expressed_in	gene	0.60
AKT1	expressed_in	gene	0.60
COMT	expressed_in	gene	0.60
BDNF	expressed_in	gene	0.60
DISC1	expressed_in	gene	0.60
GCH1	expressed_in	gene	0.60
NDEL1	expressed_in	gene	0.60
FKBP5	expressed_in	gene	0.60
NR3C1	expressed_in	gene	0.60
glioblastoma	expressed_in	disease	0.60
Rb	expressed_in	protein	0.60
CANCER	expressed_in	gene	0.60
RPA1	regulates	gene	0.60
B Cell	expressed_in	cell_type	0.55
RPA1	co_expressed_with	gene	0.50
TUMOR	expressed_in	disease	0.50
CARCINOMA	expressed_in	disease	0.50
cancer	expressed_in	disease	0.50
B Cell	interacts_with	cell_type	0.50
Microrna	interacts_with	pathway	0.50
Proteins	interacts_with	protein	0.50
B CELLS	interacts_with	concept	0.50

Incoming (6)

Source	Relation	Type	Str
CANCER	associated_with	entity	0.60
RPA1	regulates	gene	0.60
SLC6A4	expressed_in	gene	0.60
IL8	expressed_in	gene	0.60
MICRORNAS	regulates	gene	0.60
DNA	regulates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (2)

Scientific analyses that reference this entity

How does the intron-retained RNA isoform mechanistically reduce glucocerebrosida

neurodegeneration | 2026-04-26 | 7 hypotheses Top: 0.645

Extracellular vesicle biomarkers for early AD detection

neurodegeneration | 2026-04-02 | 0 hypotheses

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (2)

Multi-agent debates referencing this entity

How does the intron-retained RNA isoform mechanistically reduce glucocerebrosida

closed · Rounds: 4 · Score: 1.00 · 2026-04-26

Extracellular vesicle biomarkers for early AD detection

closed · Rounds: 4 · Score: 0.87 · 2026-04-02

Related Research

Hypotheses and analyses mentioning DICER1 in their description or question text

No additional research found