concept

INOS

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about INOS: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

422Connections

0Hypotheses

1Analyses

50Outgoing

50Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	INOS
Key Genes/Proteins	NF-KB, TG2, TREM2, CASP3, TNF
Related Diseases	ALZHEIMER'S DISEASE, PARKINSON'S DISEASE, Tumor, Parkinson, Inflammation

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    INOS["INOS"]
    style INOS fill:#1a237e,stroke:#4fc3f7,stroke-width:3px
    INOS -->|"activates"| Tumor["Tumor"]
    INOS -->|"activates"| Parkinson["Parkinson"]
    INOS -->|"activates"| Inflammation["Inflammation"]
    INOS -->|"expressed in"| ALS["ALS"]
    INOS -->|"activates"| Alzheimer["Alzheimer"]
    INOS -->|"activates"| Multiple_Sclerosis["Multiple Sclerosis"]
    INOS -->|"activates"| Huntington["Huntington"]
    INOS -->|"activates"| Neurodegeneration["Neurodegeneration"]
    INOS -->|"activates"| Ischemia["Ischemia"]
    TNF([TNF]) -.->|"inhibits"| INOS
    TGM2([TGM2]) -->|"co_expressed_with"| INOS
    IL_10([IL-10]) -->|"expressed in"| INOS
    CATALASE([CATALASE]) -->|"activates"| INOS
    OXIDATIVE_STRESS([OXIDATIVE STRESS]) -->|"activates"| INOS
    ROS([ROS]) -->|"activates"| INOS
    NRF1([NRF1]) -->|"activates"| INOS
    INFLAMMATION([INFLAMMATION]) -->|"activates"| INOS
    BDNF([BDNF]) -->|"expressed in"| INOS

Outgoing (251)

Target	Relation	Type	Str
Neurodegeneration	contributes_to	process	0.90
Tumor	activates	disease	0.65
Parkinson	activates	disease	0.65
Inflammation	activates	disease	0.65
ALS	expressed_in	disease	0.65
Alzheimer	activates	disease	0.65
Multiple Sclerosis	activates	disease	0.65
Huntington	activates	disease	0.65
Neurodegeneration	activates	disease	0.65
Ischemia	activates	disease	0.65
ALS	activates	disease	0.65
Inflammation	protects_against	disease	0.65
Neuroinflammation	activates	disease	0.65
Aging	associated_with	disease	0.65
ALS	associated_with	disease	0.65
Ischemia	inhibits	disease	0.65
Inflammation	inhibits	disease	0.65
Alzheimer	regulates	disease	0.65
Alzheimer	expressed_in	disease	0.65
Neuroinflammation	expressed_in	disease	0.65
Inflammation	expressed_in	disease	0.65
Parkinson	inhibits	disease	0.65
Stroke	activates	disease	0.65
Autoimmune	activates	disease	0.65
Als	expressed_in	disease	0.65
Als	activates	disease	0.65
Als	associated_with	disease	0.65
Aging	activates	disease	0.65
Pyroptosis	therapeutic_target	disease	0.65
Neuroinflammation	inhibits	disease	0.65
Als	regulates	disease	0.65
Depression	activates	disease	0.65
Als	inhibits	disease	0.65
Als	biomarker_for	disease	0.65
Cancer	regulates	disease	0.65
AND	activates	gene	0.60
APOPTOSIS	expressed_in	gene	0.60
PARKINSON'S DISEASE	activates	gene	0.60
TNF-Α	expressed_in	gene	0.60
HSF1	activates	gene	0.60
PARKINSON	activates	gene	0.60
GAIN	activates	gene	0.60
GSH	expressed_in	gene	0.60
CAT	expressed_in	gene	0.60
Oxidative Stress	activates	pathway	0.60
Apoptosis	expressed_in	pathway	0.60
AND	expressed_in	gene	0.60
RANK	expressed_in	gene	0.60
Oxidative Stress	expressed_in	pathway	0.60
AND	causes	gene	0.60

Incoming (171)

Source	Relation	Type	Str
NF-KB	associated_with	protein	0.96
Lipopolysaccharide	upregulates	compound	0.95
ASTROCYTES	expressed_in	cell_type	0.90
TG2	associated_with	gene	0.85
ROS	regulates	process	0.85
ALZHEIMER'S DISEASE	associated_with	disease	0.80
TREM2	upregulates	gene	0.80
Microglia-like cells	downregulates	cell_type	0.80
CASP3	associated_with	gene	0.72
PARKINSON'S DISEASE	associated_with	disease	0.72
TNF	associated_with	gene	0.72
TNF	inhibits	gene	0.64
IL-10	expressed_in	gene	0.60
CATALASE	activates	gene	0.60
OXIDATIVE STRESS	activates	gene	0.60
ROS	activates	gene	0.60
NRF1	activates	gene	0.60
INFLAMMATION	activates	gene	0.60
BDNF	expressed_in	gene	0.60
CATALASE	expressed_in	gene	0.60
IL10	expressed_in	gene	0.60
CYTOKINES	expressed_in	gene	0.60
OXIDATIVE STRESS	expressed_in	gene	0.60
GPX4	expressed_in	gene	0.60
NRF2	activates	gene	0.60
CYTOKINES	causes	gene	0.60
NF-ΚB	activates	gene	0.60
IFN	causes	gene	0.60
IL-6	causes	gene	0.60
IFN-Γ	causes	gene	0.60
TNF	causes	gene	0.60
HO-1	activates	gene	0.60
FOS	activates	gene	0.60
C-FOS	activates	gene	0.60
JUN	activates	gene	0.60
NEURODEGENERATION	activates	gene	0.60
PARKINSON	activates	gene	0.60
ALZHEIMER	activates	gene	0.60
HUNTINGTON	activates	gene	0.60
INFLAMMATION	protects_against	gene	0.60
BRAIN INJURY	protects_against	gene	0.60
OXIDATIVE STRESS	protects_against	gene	0.60
ROS	protects_against	gene	0.60
IL-10	activates	gene	0.60
CYTOKINES	activates	gene	0.60
IL-13	activates	gene	0.60
MAPK	activates	gene	0.60
P38	activates	gene	0.60
BCL-2	activates	gene	0.60
BAX	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

Lipid metabolism dysregulation and membrane integrity in Alzheimer disease

neurodegeneration | 2026-04-04 | 0 hypotheses

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

INOS

Understanding Entity Pages

Wiki Pages (20)

cbs-psp-daily-action-plan

Personalized Treatment Plan — Atypical Parkinsonism (CBS/PSP)

Corticobasal Syndrome (CBS)

Parthanatos in Neurodegeneration

Section 162: Advanced Antioxidant and Redox Therapy in CBS/PSP

neuroinflammation

Astrocyte Reactivity Mechanism

TREM2 Microglial Signaling Pathway in Neurodegeneration

Melatonin for Tauopathy: Comprehensive Evidence Synthesis

vitamin-d-therapy-neurodegeneration

Curcumin for Neurodegeneration

DNA Damage Response Impairment Pathway

Genistein for Mild Cognitive Impairment (NCT07385937)

NF-kB Signaling Pathway in Neurodegeneration

Neuroinflammation Across AD, PD, ALS, FTD, and HD

Gut-Microbiome-Neurodegeneration Axis

cGMP Signaling Pathway in Neurodegeneration

TGF-β Signaling in Parkinson's Disease

vegfr-signaling-neurodegeneration