Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about NFAT5: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
NFAT5 is a gene implicated in neurodegeneration research. Key relationships include: associated with, interacts with, therapeutic target. Associated with Cancer, Carcinoma, Tumor. Connected to 10 entities in the SciDEX knowledge graph.
| Gene Symbol | NFAT5 |
| Full Name | Nuclear Factor of Activated T Cells 5 |
| Protein Type | Transcription Factor |
| Function | NFAT5 (Nuclear Factor of Activated T Cells 5), also known as TonEBP (Tonicity-Responsive Enhancer Binding Protein), is a transcription factor that plays crucial roles in cellular stress responses. |
| Primary Expression | neurons, astrocytes, and microglia, where it contributes to: [@biomarkers2016] - Hippocampal synaptic plasticity - Astrocyte responses to injury - Mic |
| Pathways | Mapk |
| GeneCards | NFAT5 |
| Human Protein Atlas | NFAT5 |
| Osmoprotection | Regulates expression of osmolyte transporters and synthesis enzymes |
| Immune response | Controls cytokine expression in immune cells |
| Neuroprotection | Mediates cellular responses to metabolic and oxidative stress in neurons |
| Inflammation | Regulates expression of pro-inflammatory mediators in microglia and astrocytes [2] |
| Brain | Expressed in neurons (especially hippocampus), astrocytes, and microglia |
| Regional Distribution | High expression in hippocampus, cortex, and hypothalamus |
| Upregulation | Strongly induced by osmotic stress, inflammation, and neuronal injury |
| Associated Diseases | Carcinoma |
| Interactions | TNF, CANCER, RNA, JUN, CD4, SGK1 |
| KG Connections | 24 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
NFAT5["<b>NFAT5</b>"]
Carcinoma{"Carcinoma"}
NFAT5 -->|"associated with"| Carcinoma
Cancer{"Cancer"}
NFAT5 -->|"interacts with"| Cancer
Tumor{"Tumor"}
NFAT5 -->|"therapeutic target"| Tumor
CANCER["CANCER"]
NFAT5 -->|"interacts with"| CANCER
WIPI2["WIPI2"]
NFAT5 -->|"associated with"| WIPI2
FURIN["FURIN"]
NFAT5 -->|"associated with"| FURIN
JUN["JUN"]
NFAT5 -->|"interacts with"| JUN
neurodegeneration["neurodegeneration"]
NFAT5 -->|"implicated in"| neurodegeneration
RRAGA["RRAGA"]
RRAGA -->|"associated with"| NFAT5
MIRNAS["MIRNAS"]
MIRNAS -->|"therapeutic target"| NFAT5
style NFAT5 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Carcinoma | associated_with | disease | 0.65 |
| Cancer | interacts_with | disease | 0.65 |
| Tumor | therapeutic_target | disease | 0.65 |
| Autoimmune | activates | disease | 0.65 |
| Multiple Sclerosis | activates | disease | 0.65 |
| Als | activates | disease | 0.65 |
| WIPI2 | associated_with | gene | 0.60 |
| TNF | activates | gene | 0.60 |
| CANCER | interacts_with | gene | 0.60 |
| FURIN | associated_with | gene | 0.60 |
| Mapk | activates | pathway | 0.60 |
| RNA | interacts_with | gene | 0.60 |
| T cells | expressed_in | cell_type | 0.55 |
| JUN | interacts_with | protein | 0.52 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||