gene

RRAGA

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about RRAGA: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

60Connections

0Hypotheses

0Analyses

41Outgoing

19Incoming

Summary

Comprehensive gene page for RRAGA (RagA), a Rag GTPase regulating mTORC1 activation, autophagy, and lysosomal function in neurodegenerative diseases

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🧬 Gene Info

Gene Symbol	RRAGA
Full Name	Ras-Related GTP Binding A
Chromosome	9p21.1
Function	is a member of the Rag GTPase family that plays a central role in regulating the mTORC1 (mechanistic target of rapamycin complex 1) signaling pathway<sup>[1]</sup>.
Pathways	mTOR, mtor
UniProt ID	[Q9Y282](https://www.uniprot.org/uniprot/Q9Y282)
Ensembl ID	ENSG00000136996
OMIM	608456
GeneCards	RRAGA
Human Protein Atlas	RRAGA
GxxxxGKST motif	Phosphate-binding loop (P-loop) for nucleotide binding
NKXD motif	Specific to GTPases, involved in GDP/GTP binding
Switch I region	Undergoes conformational changes between GDP/GTP states
Switch II region	Critical for effector interactions
C-terminal region	Mediates dimerization with RagC/D
Associated Diseases	Cancer, Carcinoma
Interactions	G3BP1, JUN, MAPT, RRAGB, TIA1, EIF2A
KG Connections	60 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (7)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    RRAGA["RRAGA"]
    RRAGA -->|"binds"| RPTOR["RPTOR"]
    RRAGA -->|"activates"| MTORC1["MTORC1"]
    RRAGA -->|"interacts"| Cancer["Cancer"]
    RRAGA -->|"interacts"| Aging["Aging"]
    RRAGA -->|"interacts"| Ms["Ms"]
    RRAGA -->|"interacts"| Als["Als"]
    RRAGA -->|"target for"| Tumor["Tumor"]
    RRAGA -->|"interacts"| ALS["ALS"]
    GABARAP["GABARAP"] -->|"interacts"| RRAGA
    ATF4["ATF4"] -->|"interacts"| RRAGA
    FMR1["FMR1"] -->|"interacts"| RRAGA
    MTOR["MTOR"] -->|"interacts"| RRAGA
    ATG["ATG"] -->|"interacts"| RRAGA
    JUN["JUN"] -->|"interacts"| RRAGA
    EIF2A["EIF2A"] -->|"interacts"| RRAGA
    G3BP1["G3BP1"] -->|"interacts"| RRAGA

Outgoing (41)

Target	Relation	Type	Str
RPTOR	binds	gene	0.90
MTORC1	activates	entity	0.90
Cancer	interacts_with	disease	0.65
Aging	interacts_with	disease	0.65
Ms	interacts_with	disease	0.65
Als	interacts_with	disease	0.65
Aging	regulates	disease	0.65
Cancer	regulates	disease	0.65
Carcinoma	associated_with	disease	0.65
Cancer	associated_with	disease	0.65
Tumor	therapeutic_target	disease	0.65
ALS	interacts_with	disease	0.65
G3BP1	interacts_with	gene	0.60
JUN	interacts_with	gene	0.60
MAPT	interacts_with	gene	0.60
RRAGB	interacts_with	gene	0.60
TIA1	interacts_with	gene	0.60
EIF2A	interacts_with	gene	0.60
NFAT5	associated_with	gene	0.60
WIPI2	associated_with	gene	0.60
FMR1	interacts_with	gene	0.60
TAU	interacts_with	gene	0.60
MTOR	interacts_with	gene	0.60
ATF4	interacts_with	gene	0.60
RRAGB	activates	entity	0.60
Mtor	interacts_with	pathway	0.60
Er Stress	interacts_with	pathway	0.60
Autophagy	interacts_with	pathway	0.60
Autophagy	regulates	pathway	0.60
Er Stress	regulates	pathway	0.60
MIRNAS	therapeutic_target	gene	0.60
CANCER	associated_with	gene	0.60
FURIN	associated_with	gene	0.60
CANCER	interacts_with	gene	0.60
ATG	interacts_with	gene	0.60
AUTOPHAGY	interacts_with	gene	0.60
LYSOSOME	interacts_with	gene	0.60
ATG8	interacts_with	gene	0.60
AND	interacts_with	gene	0.60
GABA	interacts_with	gene	0.60
LYSOSOME	activates	gene	0.50

Incoming (19)

Source	Relation	Type	Str
GABARAP	interacts_with	gene	0.60
ATF4	interacts_with	gene	0.60
FMR1	interacts_with	gene	0.60
MTOR	interacts_with	gene	0.60
JUN	interacts_with	gene	0.60
EIF2A	interacts_with	gene	0.60
G3BP1	interacts_with	gene	0.60
ATF4	regulates	gene	0.60
MAPT	interacts_with	gene	0.60
MTOR	activates	entity	0.60
NUFIP2	interacts_with	gene	0.60
ATG	interacts_with	gene	0.60
ATG	regulates	gene	0.60
ATG8	interacts_with	gene	0.60
LGALS8	interacts_with	gene	0.60
AUTOPHAGY	interacts_with	gene	0.60
LYSOSOME	interacts_with	gene	0.60
RNA	interacts_with	gene	0.60
mTOR	activates	entity	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

RRAGA

Understanding Entity Pages

Summary

Wiki Pages (7)

RRAGA — Ras-Related GTP Binding A

RRAGB — Ras-Related GTP Binding B

SGK3 - Serum/Glucocorticoid Regulated Kinase 3

rragc

mTORC1 Protein — Mechanistic Target of Rapamycin Complex 1

NFAT5 — Nuclear Factor of Activated T Cells 5