gene

WIPI2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about WIPI2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

440Connections

0Hypotheses

1Analyses

50Outgoing

50Incoming

0Experiments

1Debates

Summary

Page for WIPI2 - WD Repeat Domain, Phosphoinositide Interacting 2

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🧬 Gene Info

Gene Symbol	WIPI2
Aliases	Page for WIPI2, WD repeat domain, phosphoinositide-interacting protein 2
Chromosome	7q36.3
Protein Family	PROPPIN family (beta-propeller, PI3P binding)
Function	encodes a 445-amino acid protein with a molecular mass of approximately 46 kDa.
Molecular Weight	46 kDa
Amino Acids	466 aa
Exons	16
Pathways	Autophagy, Cell Cycle, Mitophagy
UniProt ID	[Q9Y5P8](https://www.uniprot.org/uniprot/Q9Y5P8)
Ensembl ID	ENSG00000157911
GeneCards	WIPI2
Human Protein Atlas	WIPI2
Associated Diseases	Als, Amyotrophic Lateral Sclerosis, Ataxia, Cancer, Carcinoma, Dementia
Known Drugs/Compounds	rapamycin
Interactions	ACAT1, Actin, ALS4, AMPK, amyotrophic lateral sclerosis, AND
KG Connections	440 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

flowchart TD
    WIPI2["WIPI2
Autophagy Regulator"]
    
    BECN1["BECN1
Autophagy Initiation"]
    PIK3C3["PIK3C3
PI3K Complex"]
    MTOR["MTOR
Growth Signaling"]
    
    NBR1["NBR1
Cargo Receptor"]
    NDP52["NDP52
Selective Autophagy"]
    VAMP8["VAMP8
Vesicle Fusion"]
    
    HDAC6["HDAC6
Protein Deacetylase"]
    HSP70["HSP70
Protein Folding"]
    
    Autophagy["Autophagy
Process"]
    ProteinAggregates["Protein Aggregate
Clearance"]
    
    ALS["Amyotrophic
Lateral Sclerosis"]
    PD["Parkinson's
Disease"]
    FTD["Frontotemporal
Dementia"]
    SMA["Spinal Muscular
Atrophy"]
    Ataxia["Ataxia"]
    
    WIPI2 -->|"interacts with"| BECN1
    WIPI2 -->|"interacts with"| PIK3C3
    BECN1 -->|"forms complex"| PIK3C3
    MTOR -->|"inhibits"| Autophagy
    
    WIPI2 -->|"recruits"| NBR1
    WIPI2 -->|"recruits"| NDP52
    WIPI2 -->|"regulates"| VAMP8
    
    WIPI2 -->|"activates"| Autophagy
    Autophagy -->|"promotes"| ProteinAggregates
    
    HDAC6 -->|"facilitates"| ProteinAggregates
    HSP70 -->|"assists"| ProteinAggregates
    
    WIPI2 -->|"dysfunction leads to"| ALS
    WIPI2 -->|"dysfunction leads to"| PD
    WIPI2 -->|"dysfunction leads to"| FTD
    WIPI2 -->|"dysfunction leads to"| SMA
    WIPI2 -->|"dysfunction leads to"| Ataxia
    
    style WIPI2 fill:#006494
    style Autophagy fill:#1b5e20
    style ProteinAggregates fill:#1b5e20
    style BECN1 fill:#4a1a6b
    style PIK3C3 fill:#4a1a6b
    style MTOR fill:#4a1a6b
    style NBR1 fill:#4a1a6b
    style NDP52 fill:#4a1a6b
    style ALS fill:#5d4400
    style PD fill:#5d4400
    style FTD fill:#5d4400
    style SMA fill:#5d4400
    style Ataxia fill:#5d4400

Outgoing (242)

Target	Relation	Type	Str
autophagy pathway	participates_in	pathway	0.80
Reticulophagy	associated_with	process	0.80
Parkinson	associated_with	disease	0.75
Als	associated_with	disease	0.75
Autophagy	associated_with	pathway	0.70
MTOR	associated_with	gene	0.70
Mtor	associated_with	pathway	0.70
Als	regulates	disease	0.65
Spinocerebellar Ataxia	associated_with	disease	0.65
Ataxia	associated_with	disease	0.65
Tumor	activates	disease	0.65
Ftd	associated_with	disease	0.65
Ms	regulates	disease	0.65
Tumor	expressed_in	disease	0.65
Tumor	associated_with	disease	0.65
Frontotemporal Dementia	associated_with	disease	0.65
Carcinoma	inhibits	disease	0.65
Spinal Muscular Atrophy	associated_with	disease	0.65
Cancer	activates	disease	0.65
Senescence	regulates	disease	0.65
Dementia	associated_with	disease	0.65
Amyotrophic Lateral Sclerosis	associated_with	disease	0.65
Inflammation	associated_with	disease	0.65
Rheumatoid Arthritis	associated_with	disease	0.65
Osteoarthritis	associated_with	disease	0.65
Tumor	therapeutic_target	disease	0.65
Cancer	associated_with	disease	0.65
Carcinoma	associated_with	disease	0.65
Cancer	expressed_in	disease	0.65
Als	expressed_in	disease	0.65
Ms	inhibits	disease	0.65
Epilepsy	expressed_in	disease	0.65
Ms	associated_with	disease	0.65
STX17	associated_with	gene	0.60
CALCOCO2	associated_with	gene	0.60
ACTB	associated_with	gene	0.60
SMCR8	regulates	gene	0.60
ULK1	regulates	gene	0.60
C9ORF72	regulates	gene	0.60
UBIQUITIN	interacts_with	gene	0.60
PINK1	regulates	gene	0.60
KAT5	associated_with	gene	0.60
ATG16L1	interacts_with	gene	0.60
ATG5	interacts_with	gene	0.60
LC3	interacts_with	gene	0.60
WIPI4	activates	gene	0.60
WIPI1	interacts_with	gene	0.60
SMAD7	activates	gene	0.60
HUNTINGTIN	associated_with	gene	0.60
GABARAP	associated_with	gene	0.60

Incoming (198)

Source	Relation	Type	Str
TFEB	induces_transcription	transcription_factor	0.90
CRL4	ubiquitinates	entity	0.80
VAPs	associated_with	protein	0.80
LYSOSOME	regulates	gene	0.70
PARKINSON	associated_with	gene	0.70
ATG	associated_with	gene	0.70
AUTOPHAGY	interacts_with	gene	0.70
rapamycin	targets	drug	0.70
MAP1LC3	activates	gene	0.70
LC3	activates	gene	0.70
GABARAP	associated_with	gene	0.70
LC3	associated_with	gene	0.70
CALCOCO2	associated_with	gene	0.70
RB1	associated_with	gene	0.70
SQSTM1	associated_with	gene	0.70
PIK3C3	associated_with	gene	0.70
RB1CC1	associated_with	gene	0.70
OPTN	associated_with	gene	0.70
PARKIN	regulates	gene	0.60
NRF1	regulates	gene	0.60
SQSTM1	regulates	gene	0.60
CERS6	expressed_in	gene	0.60
ATG12	interacts_with	gene	0.60
PI3K	interacts_with	gene	0.60
ATG16L1	interacts_with	gene	0.60
MYC	activates	gene	0.60
GABARAP	interacts_with	gene	0.60
WIPI3	activates	gene	0.60
CLN3	expressed_in	gene	0.60
GABARAPL2	expressed_in	gene	0.60
SNX2	expressed_in	gene	0.60
ATG10	expressed_in	gene	0.60
RRAGA	associated_with	gene	0.60
NFAT5	associated_with	gene	0.60
NDP52	associated_with	gene	0.60
VAMP8	associated_with	gene	0.60
DNMT1	associated_with	gene	0.60
ALS4	associated_with	gene	0.60
BECN1	expressed_in	gene	0.60
ATG5	expressed_in	gene	0.60
SQSTM1	expressed_in	gene	0.60
LAMP1	expressed_in	gene	0.60
ATG16L1	expressed_in	gene	0.60
OPTINEURIN	associated_with	gene	0.60
HTT	associated_with	gene	0.60
SETX	associated_with	gene	0.60
RB1	activates	gene	0.60
KRAS	activates	gene	0.60
CANCER	activates	gene	0.60
AUTOPHAGY	regulates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

Does TFEB activation directly restore mutant GBA enzyme activity or only enhance

molecular biology | 2026-04-11 | 0 hypotheses

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

The debate identified this as a critical mechanistic gap - TFEB may increase lys

closed · Rounds: 4 · Score: 0.30 · 2026-04-21

Related Research

Hypotheses and analyses mentioning WIPI2 in their description or question text

No additional research found