WIPI2

Understanding Entity Pages

This page aggregates everything SciDEX knows about WIPI2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

Page for WIPI2 - WD Repeat Domain, Phosphoinositide Interacting 2

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flowchart TD
    WIPI2["WIPI2<br/>Autophagy Regulator"]
    
    BECN1["BECN1<br/>Autophagy Initiation"]
    PIK3C3["PIK3C3<br/>PI3K Complex"]
    MTOR["MTOR<br/>Growth Signaling"]
    
    NBR1["NBR1<br/>Cargo Receptor"]
    NDP52["NDP52<br/>Selective Autophagy"]
    VAMP8["VAMP8<br/>Vesicle Fusion"]
    
    HDAC6["HDAC6<br/>Protein Deacetylase"]
    HSP70["HSP70<br/>Protein Folding"]
    
    Autophagy["Autophagy<br/>Process"]
    ProteinAggregates["Protein Aggregate<br/>Clearance"]
    
    ALS["Amyotrophic<br/>Lateral Sclerosis"]
    PD["Parkinson's<br/>Disease"]
    FTD["Frontotemporal<br/>Dementia"]
    SMA["Spinal Muscular<br/>Atrophy"]
    Ataxia["Ataxia"]
    
    WIPI2 --|"interacts with"|--> BECN1
    WIPI2 --|"interacts with"|--> PIK3C3
    BECN1 --|"forms complex"|--> PIK3C3
    MTOR --|"inhibits"|--> Autophagy
    
    WIPI2 --|"recruits"|--> NBR1
    WIPI2 --|"recruits"|--> NDP52
    WIPI2 --|"regulates"|--> VAMP8
    
    WIPI2 --|"activates"|--> Autophagy
    Autophagy --|"promotes"|--> ProteinAggregates
    
    HDAC6 --|"facilitates"|--> ProteinAggregates
    HSP70 --|"assists"|--> ProteinAggregates
    
    WIPI2 --|"dysfunction leads to"|--> ALS
    WIPI2 --|"dysfunction leads to"|--> PD
    WIPI2 --|"dysfunction leads to"|--> FTD
    WIPI2 --|"dysfunction leads to"|--> SMA
    WIPI2 --|"dysfunction leads to"|--> Ataxia
    
    style WIPI2 fill:#006494
    style Autophagy fill:#1b5e20
    style ProteinAggregates fill:#1b5e20
    style BECN1 fill:#4a1a6b
    style PIK3C3 fill:#4a1a6b
    style MTOR fill:#4a1a6b
    style NBR1 fill:#4a1a6b
    style NDP52 fill:#4a1a6b
    style ALS fill:#5d4400
    style PD fill:#5d4400
    style FTD fill:#5d4400
    style SMA fill:#5d4400
    style Ataxia fill:#5d4400