Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about NPAS2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Gene Symbol | NPAS2 |
| Full Name | Neuronal PAS Domain Protein 2 |
| Chromosome | 2q22.1 |
| Function | The NPAS2 gene encodes Neuronal PAS Domain Protein 2, a transcription factor that serves as a core component of the mammalian circadian clock. |
| Molecular Weight | 87 kDa |
| Pathways | CBFs |
| UniProt ID | Q8BZD0 |
| NCBI Gene ID | 10327 |
| Ensembl ID | ENSG00000107077 |
| OMIM | 605504 |
| GeneCards | NPAS2 |
| Human Protein Atlas | NPAS2 |
| Associated Diseases | Freezing Tolerance |
| Interactions | PER1, PER2, BMAL1, MTNR1A, MTNR1B |
| KG Connections | 38 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
NPAS2["<b>NPAS2</b>"]
BMAL1["BMAL1"]
NPAS2 -->|"interacts with"| BMAL1
CRY2["CRY2"]
NPAS2 -->|"associated with"| CRY2
PER2["PER2"]
NPAS2 -->|"associated with"| PER2
CLOCK["CLOCK"]
NPAS2 -->|"associated with"| CLOCK
NPAS2 -->|"associated with"| BMAL1
neurodegeneration["neurodegeneration"]
NPAS2 -->|"implicated in"| neurodegeneration
PER3["PER3"]
PER3 -->|"associated with"| NPAS2
PER1["PER1"]
PER1 -->|"associated with"| NPAS2
CRY1["CRY1"]
CRY1 -->|"associated with"| NPAS2
style NPAS2 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| HOS1 | interacts_with | enzyme | 0.80 |
| CBFs | participates_in | pathway | 0.80 |
| Freezing Tolerance | associated_with | phenotype | 0.80 |
| BMAL1 | interacts_with | protein | 0.70 |
| Sleep Disorder | expressed_in | disease | 0.65 |
| Als | expressed_in | disease | 0.65 |
| Autism | expressed_in | disease | 0.65 |
| ALS | expressed_in | disease | 0.65 |
| CRY2 | associated_with | gene | 0.60 |
| PER2 | associated_with | gene | 0.60 |
| CLOCK | associated_with | gene | 0.60 |
| BMAL1 | associated_with | gene | 0.60 |
| MTNR1A | associated_with | gene | 0.60 |
| PER3 | expressed_in | gene | 0.60 |
| PER1 | associated_with | gene | 0.60 |
| NR1D1 | expressed_in | gene | 0.60 |
| MTNR1B | associated_with | gene | 0.60 |
| CLOCK | expressed_in | gene | 0.60 |
| ARNTL | expressed_in | gene | 0.60 |
| Rb | expressed_in | protein | 0.60 |
| autism spectrum disorder | interacts_with | disease | 0.60 |
| PER1 | interacts_with | protein | 0.50 |
| PER2 | interacts_with | protein | 0.50 |
| MTNR1B | interacts_with | concept | 0.50 |
| Source | Relation | Type | Str |
|---|---|---|---|
| PER3 | associated_with | gene | 0.60 |
| PER1 | associated_with | gene | 0.60 |
| CRY1 | associated_with | gene | 0.60 |
| ARNTL | expressed_in | gene | 0.60 |
| PER3 | expressed_in | gene | 0.60 |
| MTNR1A | associated_with | gene | 0.60 |
| MTNR1B | associated_with | gene | 0.60 |
| NR1D1 | expressed_in | gene | 0.60 |
| PER2 | associated_with | gene | 0.60 |
| CLOCK | expressed_in | gene | 0.60 |
| MTNR1B | interacts_with | gene | 0.60 |
| GENES | expressed_in | gene | 0.60 |
| AND | associated_with | gene | 0.60 |
| MTNR1A | interacts_with | gene | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||