Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about PER3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Gene Symbol | PER3 |
| Full Name | Period Circadian Regulator 3 |
| Chromosome | 1p36.23 |
| Function | The PER3 gene encodes the Period Circadian Regulator 3 protein, a core component of the mammalian circadian clock. |
| Molecular Weight | 121 kDa |
| Pathways | ubiquitin-proteasome |
| UniProt ID | Q8WY51 |
| NCBI Gene ID | 8863 |
| Ensembl ID | ENSG00000149257 |
| OMIM | 604352 |
| GeneCards | PER3 |
| Human Protein Atlas | PER3 |
| Associated Diseases | ALS, autism spectrum disorder |
| Interactions | HCRTR2, PER2 |
| KG Connections | 57 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
PER3["<b>PER3</b>"]
Carcinoma{"Carcinoma"}
PER3 -->|"expressed in"| Carcinoma
Cancer{"Cancer"}
PER3 -->|"expressed in"| Cancer
Tumor{"Tumor"}
PER3 -->|"expressed in"| Tumor
PER1["PER1"]
PER3 -->|"expressed in"| PER1
CRY1["CRY1"]
PER3 -->|"expressed in"| CRY1
CRY2["CRY2"]
PER3 -->|"expressed in"| CRY2
PER2["PER2"]
PER3 -->|"expressed in"| PER2
CANCER["CANCER"]
PER3 -->|"expressed in"| CANCER
SIRT1["SIRT1"]
PER3 -->|"expressed in"| SIRT1
CLOCK["CLOCK"]
PER3 -->|"expressed in"| CLOCK
AUTOPHAGY["AUTOPHAGY"]
PER3 -->|"expressed in"| AUTOPHAGY
APOPTOSIS["APOPTOSIS"]
PER3 -->|"expressed in"| APOPTOSIS
style PER3 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Sleep Disorder | expressed_in | disease | 0.65 |
| Carcinoma | expressed_in | disease | 0.65 |
| Cancer | expressed_in | disease | 0.65 |
| Tumor | expressed_in | disease | 0.65 |
| Als | expressed_in | disease | 0.65 |
| Autism | expressed_in | disease | 0.65 |
| ALS | expressed_in | disease | 0.65 |
| PER1 | expressed_in | gene | 0.60 |
| CRY1 | expressed_in | gene | 0.60 |
| CRY2 | expressed_in | gene | 0.60 |
| PER2 | expressed_in | gene | 0.60 |
| SIRT1 | expressed_in | gene | 0.60 |
| CLOCK | expressed_in | gene | 0.60 |
| PER1 | associated_with | gene | 0.60 |
| CRY1 | associated_with | gene | 0.60 |
| NPAS2 | associated_with | gene | 0.60 |
| CRY2 | associated_with | gene | 0.60 |
| PER2 | associated_with | gene | 0.60 |
| CLOCK | associated_with | gene | 0.60 |
| BMAL1 | associated_with | gene | 0.60 |
| NR1D1 | expressed_in | gene | 0.60 |
| MTNR1B | expressed_in | gene | 0.60 |
| ARNTL | expressed_in | gene | 0.60 |
| MTNR1A | expressed_in | gene | 0.60 |
| NPAS2 | expressed_in | gene | 0.60 |
| Rb | expressed_in | protein | 0.60 |
| CANCER | expressed_in | gene | 0.60 |
| AUTOPHAGY | expressed_in | gene | 0.60 |
| APOPTOSIS | expressed_in | gene | 0.60 |
| Apoptosis | expressed_in | pathway | 0.60 |
| Autophagy | expressed_in | pathway | 0.60 |
| AND | expressed_in | gene | 0.60 |
| autism spectrum disorder | associated_with | disease | 0.60 |
| ubiquitin-proteasome | participates_in | pathway | 0.60 |
| ALS | associated_with | disease | 0.60 |
| MAPK signaling | participates_in | pathway | 0.60 |
| apoptosis pathway | participates_in | pathway | 0.60 |
| MTNR1B | associated_with | concept | 0.50 |
| Source | Relation | Type | Str |
|---|---|---|---|
| NPAS2 | expressed_in | gene | 0.60 |
| MTNR1A | expressed_in | gene | 0.60 |
| PER2 | expressed_in | gene | 0.60 |
| ARNTL | expressed_in | gene | 0.60 |
| NR1D1 | expressed_in | gene | 0.60 |
| MTNR1B | expressed_in | gene | 0.60 |
| MTNR1B | associated_with | gene | 0.60 |
| PER1 | associated_with | gene | 0.60 |
| PER2 | associated_with | gene | 0.60 |
| PER1 | biomarker_for | gene | 0.60 |
| HCRTR2 | interacts_with | gene | 0.60 |
| PER2 | interacts_with | gene | 0.60 |
| GENES | expressed_in | gene | 0.60 |
| MAPK | regulates | gene | 0.60 |
| ARNTL | associated_with | gene | 0.50 |
| CLOCK | associated_with | gene | 0.50 |
| NR1D1 | associated_with | gene | 0.50 |
| HCRTR2 | co_expressed_with | gene | 0.50 |
| PER2 | co_expressed_with | protein | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||