concept

PI3K/AKT/MTOR PATHWAY

Entity Detail — Knowledge Graph Node

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This page aggregates everything SciDEX knows about PI3K/AKT/MTOR PATHWAY: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

92Connections

0Hypotheses

2Analyses

50Outgoing

33Incoming

0Experiments

7Debates

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💡 Concept Info

Name	PI3K/AKT/MTOR PATHWAY

Pathway Diagram

graph TD
    PI3K_AKT_MTOR_PATHWAY["PI3K/AKT/MTOR PATHWAY"]
    PI3K_AKT_MTOR_PATHWAY -->|"involved_in"| Cancer["Cancer"]
    PI3K_AKT_MTOR_PATHWAY -->|"contributes to"| Hormone_Receptor_Positive_Adva["Hormone Receptor-Positive Advanced Breast Cancer"]
    PI3K_AKT_MTOR_PATHWAY -->|"involved_in"| Breast_Cancer["Breast Cancer"]
    PI3K_AKT_MTOR_PATHWAY -->|"promotes"| Tumor_Growth["Tumor Growth"]
    PI3K_AKT_MTOR_PATHWAY -->|"mediates"| Endocrine_Therapy_Resistance["Endocrine Therapy Resistance"]
    PI3K_AKT_MTOR_PATHWAY -->|"mediates"| Cdk4_6_Inhibitor_Resistance["Cdk4/6 Inhibitor Resistance"]
    PI3K_AKT_MTOR_PATHWAY -->|"promotes"| cell_survival["cell survival"]
    PI3K_AKT_MTOR_PATHWAY -->|"promotes"| dystrophic_neurites["dystrophic neurites"]
    Piperine["Piperine"] -->|"activates"| PI3K_AKT_MTOR_PATHWAY
    PIK3CA["PIK3CA"] -->|"involved_in"| PI3K_AKT_MTOR_PATHWAY
    CHRYSOTOXINE["CHRYSOTOXINE"] -->|"inhibits"| PI3K_AKT_MTOR_PATHWAY
    Capivasertib["Capivasertib"] -->|"inhibits"| PI3K_AKT_MTOR_PATHWAY
    Alpelisib["Alpelisib"] -->|"inhibits"| PI3K_AKT_MTOR_PATHWAY
    MARCKS["MARCKS"] -->|"activates"| PI3K_AKT_MTOR_PATHWAY
    insulin_resistance["insulin resistance"] -->|"inhibits"| PI3K_AKT_MTOR_PATHWAY
    STX11["STX11"] -->|"inhibits"| PI3K_AKT_MTOR_PATHWAY

Outgoing (59)

Target	Relation	Type	Str
insulin resistance	regulates	process	0.95
Hormone Receptor-Positive Advanced Breast Cancer	contributes_to	disease	0.95
Breast Cancer	involved_in	disease	0.95
Colorectal Cancer Initiation	involved_in	process	0.95
Colorectal Cancer Progression	involved_in	process	0.95
Colorectal Cancer Metastasis	promotes	process	0.95
Tumor Growth	promotes	process	0.95
Insulin Resistance	regulates	phenotype	0.95
Cancer	involved_in	disease	0.95
Breast Tumorigenesis	involved_in	process	0.95
Endocrine Therapy Resistance	mediates	mechanism	0.93
Cdk4/6 Inhibitor Resistance	mediates	mechanism	0.93
cell survival	promotes	process	0.92
dystrophic neurites	promotes	phenotype	0.92
axonal pathology	therapeutic_target	phenotype	0.90
Colorectal cancer	implicated_in	disease	0.90
Triple-negative breast cancer	implicated_in	disease	0.90
Autophagy	mediates	process	0.90
protein turnover	regulates	process	0.90
cytoskeleton dynamics	regulates	process	0.90
lipid transport	regulates	process	0.90
Drug Resistance	mediates	phenotype	0.90
Tumor Growth	involved_in	process	0.90
Breast cancer	implicated_in	disease	0.90
Pancreatic Ductal Adenocarcinoma	involved_in	disease	0.90
Cancer Progression	regulates	disease	0.90
Autophagy	mediates	process	0.90
Transcriptional Targets	regulates	process	0.90
Gene Transcription	regulates	process	0.90
insulin resistance	causes	phenotype	0.90
macrophage activation	regulates	phenotype	0.90
Endocrine Resistance	mediates	mechanism	0.90
Poor Prognosis	associated_with	phenotype	0.90
Hormone-Receptor-Positive Breast Cancer	contributes_to	disease	0.85
Sjogren's Syndrome	involved_in	disease	0.85
Protein Turnover	regulates	process	0.85
Cytoskeleton Dynamics	regulates	process	0.85
Lipid Transport	regulates	process	0.85
Bladder Cancer	drives	disease	0.85
Autophagy	regulates	process	0.85
Cancer Hallmarks	regulates	process	0.85
Cellular Growth	modulates	process	0.85
Cell Proliferation	regulates	process	0.85
Idiopathic Pulmonary Fibrosis	involved_in	disease	0.85
Tumor Invasion	involved_in	process	0.85
Apoptosis	regulates	process	0.85
Tumor Metastasis	associated_with	process	0.83
Cell Death	modulates	process	0.80
Angiogenesis	regulates	process	0.80
endocrine resistance	causes	phenotype	0.80

Incoming (33)

Source	Relation	Type	Str
Apigenin	inhibits	compound	0.95
Polyphenols	targets	compound	0.95
Piperine	activates	compound	0.95
PIK3CA	associated_with	gene	0.95
Glioblastoma Multiforme	associated_with	disease	0.95
PI3K Pathway Inhibitors	inhibits	drug	0.95
Capivasertib	inhibits	drug	0.92
Alpelisib	inhibits	drug	0.92
Piperine	activates	compound	0.90
Sijunzi Decoction	targets	drug	0.90
STX11	inhibits	gene	0.90
PTEN	inhibits	protein	0.90
SPP1	activates	protein	0.90
Berberine	inhibits	compound	0.90
Fibroblast Autophagy	inhibits	process	0.90
MARCKS	activates	protein	0.90
insulin resistance	inhibits	phenotype	0.90
41594924	promotes pro-survival autophagy by inhibiting	paper	0.90
PTEN	regulates	gene	0.90
Pi3K Inhibitors	inhibits	drug	0.90
Akt Inhibitors	inhibits	drug	0.90
Mtor Inhibitors	inhibits	drug	0.90
SYK	activates	protein	0.90
PTEN	inhibits	gene	0.90
MTOR	involved_in	gene	0.88
AKT1	involved_in	gene	0.88
IRGM1	activates	protein	0.85
KRAS	activates	gene	0.85
NOBILETIN	inhibits	compound	0.80
RAF/MEK/ERK Pathway	interacts_with	pathway	0.75
TREM2	activates	gene	0.70
41594924	inhibits	paper	0.60
Gomisin N	activates	compound	0.60