Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about PLAT: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | PLAT |
| Key Genes/Proteins | GENES, AND, ALZHEIMER, APP, CASP4, GNB5 |
| Related Diseases | Hemorrhagic Transformation, Ischemic Stroke, Brain Hemorrhagic Transformation, Alzheimer, Als |
| Linked Hypotheses | 4 hypotheses |
Knowledge base pages for this entity
graph TD
PLAT["PLAT"]
PLAT -->|"causes"| Hemorrhagic_Transformation["Hemorrhagic Transformation"]
PLAT -->|"causes"| Brain_Hemorrhagic_Transformati["Brain Hemorrhagic Transformation"]
PLAT -->|"regulates"| Alzheimer["Alzheimer"]
PLAT -->|"regulates"| Als["Als"]
PLAT -->|"regulates"| ALS["ALS"]
PLAT -->|"contributes to"| Inflammation["Inflammation"]
PLAT -->|"interacts"| GENES["GENES"]
PLAT -->|"regulates"| ALZHEIMER["ALZHEIMER"]
PKD2["PKD2"] -->|"interacts"| PLAT
PSMB5["PSMB5"] -->|"contributes to"| PLAT
NEP["NEP"] -->|"contributes to"| PLAT
PARK7["PARK7"] -->|"contributes to"| PLAT
GENES -->|"contributes to"| PLAT
INFLAMMATION["INFLAMMATION"] -->|"contributes to"| PLAT
CASP4["CASP4"] -->|"contributes to"| PLAT
ALZHEIMER -->|"regulates"| PLAT| Target | Relation | Type | Str |
|---|---|---|---|
| Hemorrhagic Transformation | causes | phenotype | 0.95 |
| Ischemic Stroke | treats | disease | 0.95 |
| Brain Hemorrhagic Transformation | causes | disease | 0.80 |
| Alzheimer | regulates | disease | 0.65 |
| Als | regulates | disease | 0.65 |
| ALS | regulates | disease | 0.65 |
| Inflammation | contributes_to | disease | 0.65 |
| GENES | interacts_with | gene | 0.60 |
| AND | associated_with | gene | 0.60 |
| ALZHEIMER | regulates | gene | 0.60 |
| APP | contributes_to | gene | 0.60 |
| CASP4 | contributes_to | gene | 0.60 |
| GNB5 | contributes_to | gene | 0.60 |
| SNCA | contributes_to | gene | 0.60 |
| ABCA1 | contributes_to | gene | 0.60 |
| Lipid Metabolism | contributes_to | pathway | 0.60 |
| Neurogenesis | contributes_to | pathway | 0.60 |
| Oxidative Stress | contributes_to | pathway | 0.60 |
| PARK7 | contributes_to | gene | 0.60 |
| PKD2 | interacts_with | gene | 0.60 |
| PSMB5 | contributes_to | gene | 0.60 |
| NEP | contributes_to | gene | 0.60 |
| App | interacts_with | protein | 0.60 |
| Ca1 | expressed_in | brain_region | 0.55 |
| Source | Relation | Type | Str |
|---|---|---|---|
| PKD2 | interacts_with | gene | 0.60 |
| PSMB5 | contributes_to | gene | 0.60 |
| NEP | contributes_to | gene | 0.60 |
| PARK7 | contributes_to | gene | 0.60 |
| GENES | contributes_to | gene | 0.60 |
| INFLAMMATION | contributes_to | gene | 0.60 |
| CASP4 | contributes_to | gene | 0.60 |
| ALZHEIMER | regulates | gene | 0.60 |
| APP | contributes_to | gene | 0.60 |
| GNB5 | contributes_to | gene | 0.60 |
| SNCA | contributes_to | gene | 0.60 |
| OXIDATIVE STRESS | contributes_to | gene | 0.60 |
| AND | contributes_to | gene | 0.60 |
| ALZHEIMER'S DISEASE | regulates | gene | 0.60 |
| NEURODEGENERATIVE DISEASES | regulates | gene | 0.60 |
| ABCA1 | contributes_to | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Pharmacogenomic CNS Drug Optimization Platform | 0.534 | neurodegeneration | How do neurodegeneration gene expression |
| Glycosaminoglycan Template Disruption Approach | 0.464 | neurodegeneration | Protein aggregation cross-seeding across |
| Multi-Modal CRISPR Platform for Simultaneous Editing and Mon | 0.423 | neurodegeneration | CRISPR-based therapeutic approaches for |
| Mitochondrial SPM Synthesis Platform Engineering | 0.383 | neurodegeneration | Neuroinflammation resolution mechanisms |
Scientific analyses that reference this entity
structural biology | 2026-04-13 | 1 hypotheses Top: 0.577
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Allosteric properties of mammalian ALOX15 orthologs. [PMID:41654134] | Yang J, Borchert A, Kuhn H | J Biol Chem | 2026 | 1 |
| SBFI26 induces triple-negative breast cancer cells ferroptosis via lipid peroxid [PMID:38516826] | He G, Zhang Y, Feng Y, Chen T, Liu M, Ze | J Cell Mol Med | 2024 | 1 |
| Mitochondrial DNA stress triggers autophagy-dependent ferroptotic death. [PMID:32186434] | Li C, Zhang Y, Liu J, Kang R, Klionsky D | Autophagy | 2021 | 1 |
| 5-lipoxygenase pathway and its downstream cysteinyl leukotrienes as potential th [PMID:32222525] | Chen F, Ghosh A, Lin J, Zhang C, Pan Y, | Brain Behav Immun | 2020 | 1 |
| Decoding cell death signals in liver inflammation. [PMID:23567086] | Brenner C, Galluzzi L, Kepp O, Kroemer G | J Hepatol | 2013 | 1 |
| Arachidonate lipoxygenase 5 metabolism axis promoting ferroptosis: a potential d [PMID:41942611] | Chen L, Sun X, Zhang H, Zhang X, Muhetar | Br J Cancer | 2026 | 0 |
| Enhancing the efficiency of bone tissue regeneration by using a 3D printed scaff [PMID:41435437] | Ku CY, Chen YH, Lin CM, Chu YH, Ho YJ, L | Biomedical materials (Bristol, | 2026 | 0 |
| Genome editing in Parkinson's disease: Unlocking therapeutic avenues through CRI [PMID:41905621] | ["Singh R", "Maity P", "Jaiswal C"] | Neurochemistry international | 2026 | 0 |
| Targeting Non-coding RNAs in Neurodegeneration: Advances in Therapeutic RNA Moda [PMID:41588889] | ["Thakur A", "Chowdhury K", "Kumar A", " | Current Alzheimer research | 2026 | 0 |
| Hereditary Polyneuropathies in the Era of Precision Medicine: Genetic Complexity [PMID:41595476] | ["Chrysostomaki M", "Chatzi D", "Kyriako | Genes | 2026 | 0 |
| Neuroinflammation, Autophagy, and Neurodegeneration: Mechanisms and Therapeutic [PMID:41918200] | ["Khanal P", "Balmik A"] | CNS & neurological disorders d | 2026 | 0 |
| Geniposidic Acid Targeting FXR "S332 and H447" Mediated Conformational Change to [PMID:39998442] | Fan M, Xu Y, Wu B, Long J, Liu C et al. | Adv Sci (Weinh) | 2025 | 0 |
| Intestinal mast cell-derived leukotrienes mediate the anaphylactic response to i [PMID:40773543] | Bachtel ND, Cullen JL, Liu M, Erickson S | Science (New York, N.Y.) | 2025 | 0 |
| Trichomonas vaginalis adhesion protein 65 facilitates human papillomavirus entry [PMID:41199321] | Mei X, Sheng W, Zhang Y, Tian W, Tian X, | Infectious diseases of poverty | 2025 | 0 |
| CRISPR-Cas technologies in neurodegenerative disorders: mechanistic insights, th [PMID:41674784] | ["Yashooa R", "Nabi A", "Smail S", "Azee | Frontiers in neurology | 2025 | 0 |
| Pharmacogenomics of Alzheimer's Disease: Novel Strategies for Drug Utilization a [PMID:36068470] | Cacabelos R, Naidoo V, Martínez-Iglesias | Methods Mol Biol | 2022 | 0 |
| The arginine methyltransferase PRMT7 promotes extravasation of monocytes resulti [PMID:35288557] | Günes Günsel G, Conlon TM, Jeridi A, Kim | Nature communications | 2022 | 0 |
| [WALANT - Wide Awake Local Anaesthesia No Tourniquet: Complications in elective [PMID:35168268] | Wieschollek S, Forster S, Megerle K | Handchirurgie, Mikrochirurgie, | 2022 | 0 |
| Magnetic control of tokamak plasmas through deep reinforcement learning. [PMID:35173339] | Degrave J, Felici F, Buchli J, Neunert M | Nature | 2022 | 0 |
| Engineering complex communities by directed evolution. [PMID:33986540] | Chang CY, Vila JCC, Bender M, Li R, Mank | Nature ecology & evolution | 2021 | 0 |