concept

PLAT

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PLAT: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

40Connections
4Hypotheses
1Analyses
24Outgoing
16Incoming

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💡 Concept Info
NamePLAT
Key Genes/ProteinsGENES, AND, ALZHEIMER, APP, CASP4, GNB5
Related DiseasesHemorrhagic Transformation, Ischemic Stroke, Brain Hemorrhagic Transformation, Alzheimer, Als
Linked Hypotheses4 hypotheses

Wiki Pages (6)

Knowledge base pages for this entity

PLAU Gene (Urokinase)

gene · 2967 words

Microglial Proteins in CSF Reveal AD Progression States

biomarker · 2643 words

PLG — Plasminogen

gene · 2063 words

Coagulation Cascade in Neurodegeneration

mechanism · 1170 words

ALOX15 Protein

protein · 746 words

Pathway Diagram

graph TD
    PLAT["PLAT"]
    PLAT -->|"causes"| Hemorrhagic_Transformation["Hemorrhagic Transformation"]
    PLAT -->|"causes"| Brain_Hemorrhagic_Transformati["Brain Hemorrhagic Transformation"]
    PLAT -->|"regulates"| Alzheimer["Alzheimer"]
    PLAT -->|"regulates"| Als["Als"]
    PLAT -->|"regulates"| ALS["ALS"]
    PLAT -->|"contributes to"| Inflammation["Inflammation"]
    PLAT -->|"interacts"| GENES["GENES"]
    PLAT -->|"regulates"| ALZHEIMER["ALZHEIMER"]
    PKD2["PKD2"] -->|"interacts"| PLAT
    PSMB5["PSMB5"] -->|"contributes to"| PLAT
    NEP["NEP"] -->|"contributes to"| PLAT
    PARK7["PARK7"] -->|"contributes to"| PLAT
    GENES -->|"contributes to"| PLAT
    INFLAMMATION["INFLAMMATION"] -->|"contributes to"| PLAT
    CASP4["CASP4"] -->|"contributes to"| PLAT
    ALZHEIMER -->|"regulates"| PLAT

Outgoing (24)

TargetRelationTypeStr
Hemorrhagic Transformationcausesphenotype0.95
Ischemic Stroketreatsdisease0.95
Brain Hemorrhagic Transformationcausesdisease0.80
Alzheimerregulatesdisease0.65
Alsregulatesdisease0.65

Incoming (16)

SourceRelationTypeStr
PKD2interacts_withgene0.60
PSMB5contributes_togene0.60
NEPcontributes_togene0.60
PARK7contributes_togene0.60
GENEScontributes_togene0.60

Targeting Hypotheses (4)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
Pharmacogenomic CNS Drug Optimization Platform 0.534 neurodegeneration How do neurodegeneration gene expression
Glycosaminoglycan Template Disruption Approach 0.464 neurodegeneration Protein aggregation cross-seeding across
Multi-Modal CRISPR Platform for Simultaneous Editing and Mon 0.423 neurodegeneration CRISPR-based therapeutic approaches for
Mitochondrial SPM Synthesis Platform Engineering 0.383 neurodegeneration Neuroinflammation resolution mechanisms

Mentioning Analyses (1)

Scientific analyses that reference this entity

What is the atomic-resolution structure of K280-acetylated tau and how does it t

structural biology | 2026-04-13 | 1 hypotheses Top: 0.577

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
Allosteric properties of mammalian ALOX15 orthologs. [PMID:41654134] Yang J, Borchert A, Kuhn H J Biol Chem 2026 1
SBFI26 induces triple-negative breast cancer cells ferroptosis via lipid peroxid [PMID:38516826] He G, Zhang Y, Feng Y, Chen T, Liu M, Ze J Cell Mol Med 2024 1
Mitochondrial DNA stress triggers autophagy-dependent ferroptotic death. [PMID:32186434] Li C, Zhang Y, Liu J, Kang R, Klionsky D Autophagy 2021 1
5-lipoxygenase pathway and its downstream cysteinyl leukotrienes as potential th [PMID:32222525] Chen F, Ghosh A, Lin J, Zhang C, Pan Y, Brain Behav Immun 2020 1
Decoding cell death signals in liver inflammation. [PMID:23567086] Brenner C, Galluzzi L, Kepp O, Kroemer G J Hepatol 2013 1
Arachidonate lipoxygenase 5 metabolism axis promoting ferroptosis: a potential d [PMID:41942611] Chen L, Sun X, Zhang H, Zhang X, Muhetar Br J Cancer 2026 0
Enhancing the efficiency of bone tissue regeneration by using a 3D printed scaff [PMID:41435437] Ku CY, Chen YH, Lin CM, Chu YH, Ho YJ, L Biomedical materials (Bristol, 2026 0
Genome editing in Parkinson's disease: Unlocking therapeutic avenues through CRI [PMID:41905621] ["Singh R", "Maity P", "Jaiswal C"] Neurochemistry international 2026 0
Targeting Non-coding RNAs in Neurodegeneration: Advances in Therapeutic RNA Moda [PMID:41588889] ["Thakur A", "Chowdhury K", "Kumar A", " Current Alzheimer research 2026 0
Hereditary Polyneuropathies in the Era of Precision Medicine: Genetic Complexity [PMID:41595476] ["Chrysostomaki M", "Chatzi D", "Kyriako Genes 2026 0
Neuroinflammation, Autophagy, and Neurodegeneration: Mechanisms and Therapeutic [PMID:41918200] ["Khanal P", "Balmik A"] CNS & neurological disorders d 2026 0
Geniposidic Acid Targeting FXR "S332 and H447" Mediated Conformational Change to [PMID:39998442] Fan M, Xu Y, Wu B, Long J, Liu C et al. Adv Sci (Weinh) 2025 0
Intestinal mast cell-derived leukotrienes mediate the anaphylactic response to i [PMID:40773543] Bachtel ND, Cullen JL, Liu M, Erickson S Science (New York, N.Y.) 2025 0
Trichomonas vaginalis adhesion protein 65 facilitates human papillomavirus entry [PMID:41199321] Mei X, Sheng W, Zhang Y, Tian W, Tian X, Infectious diseases of poverty 2025 0
CRISPR-Cas technologies in neurodegenerative disorders: mechanistic insights, th [PMID:41674784] ["Yashooa R", "Nabi A", "Smail S", "Azee Frontiers in neurology 2025 0
Pharmacogenomics of Alzheimer's Disease: Novel Strategies for Drug Utilization a [PMID:36068470] Cacabelos R, Naidoo V, Martínez-Iglesias Methods Mol Biol 2022 0
The arginine methyltransferase PRMT7 promotes extravasation of monocytes resulti [PMID:35288557] Günes Günsel G, Conlon TM, Jeridi A, Kim Nature communications 2022 0
[WALANT - Wide Awake Local Anaesthesia No Tourniquet: Complications in elective [PMID:35168268] Wieschollek S, Forster S, Megerle K Handchirurgie, Mikrochirurgie, 2022 0
Magnetic control of tokamak plasmas through deep reinforcement learning. [PMID:35173339] Degrave J, Felici F, Buchli J, Neunert M Nature 2022 0
Engineering complex communities by directed evolution. [PMID:33986540] Chang CY, Vila JCC, Bender M, Li R, Mank Nature ecology & evolution 2021 0