protein

CASP4

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CASP4: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

163Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

CASP4 is a protein involved in neurodegeneration research. Key relationships include: associated with, causes, inhibits. Associated with Aging, Als, Multiple Sclerosis. Connected to 36 entities in the SciDEX knowledge graph.

View on Wiki →

🔬 Protein Info

Gene Symbol	CASP4
Full Name	Caspase-4
Chromosome	11q22.2
Protein Family	Caspase family, inflammatory caspases (CASP1, CASP4, CASP5)
Protein Type	Protease
Function	Under conditions of ER stress, such as accumulation of misfolded proteins, CASP4 can be activated directly without inflammasome assembly.
Primary Expression	Broad, high in immune cells, CNS neurons and glia
Subcellular Localization	Cytoplasm, ER membrane, mitochondria
Molecular Weight	45 kDa
Pathways	Mitochondrial Function, Oxidative Stress, pyroptosis
UniProt ID	P49662
NCBI Gene ID	837
Ensembl ID	ENSG00000100994
OMIM	602754
GeneCards	CASP4
Human Protein Atlas	CASP4
Associated Diseases	Aging, Als, Alzheimer, Cancer, Dementia, Multiple Sclerosis
Interactions	CASP1, Rb, AUTOPHAGY, Caspase, Actin, Ras
KG Connections	163 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: CASP4 — AlphaFold P49662 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (8)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    CASP4["CASP4 (Caspase-4)"]
    AGING["Aging"]
    OXSTRESS["Oxidative Stress"]
    NEURODEGENERATION["Neurodegeneration"]
    ALS["ALS"]
    MS["Multiple Sclerosis"]
    CASP1["CASP1"]
    MICROGLIA["Microglia Activation"]
    IL18["IL-18"]
    APOPTOSIS["Apoptosis"]
    AUTOPHAGY["Autophagy"]
    ATG7["ATG7"]
    ATG5["ATG5"]
    BECN1["BECN1"]
    TLR["Toll-like Receptors"]
    IFNG["IFN-gamma"]

    AGING -->|"upregulates"| CASP4
    OXSTRESS -->|"activates"| CASP4
    IFNG -->|"induces"| CASP4
    TLR -->|"signals to"| CASP4
    
    CASP4 -->|"inhibits"| CASP1
    CASP4 -->|"activates"| MICROGLIA
    CASP4 -->|"promotes"| IL18
    CASP4 -->|"triggers"| APOPTOSIS
    CASP4 -->|"regulates"| AUTOPHAGY
    
    CASP4 -->|"contributes to"| ALS
    CASP4 -->|"contributes to"| MS
    CASP4 -->|"paradoxically inhibits"| NEURODEGENERATION
    
    AUTOPHAGY -->|"involves"| ATG7
    AUTOPHAGY -->|"involves"| ATG5
    AUTOPHAGY -->|"involves"| BECN1

    style CASP4 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px
    style NEURODEGENERATION fill:#ef5350,stroke:#333,stroke-width:2px
    style ALS fill:#7d4200,stroke:#333,stroke-width:2px
    style MS fill:#7d4200,stroke:#333,stroke-width:2px
    style AGING fill:#7d4200,stroke:#333,stroke-width:2px
    style OXSTRESS fill:#ef5350,stroke:#333,stroke-width:2px
    style APOPTOSIS fill:#ef5350,stroke:#333,stroke-width:2px
    style AUTOPHAGY fill:#1b5e20,stroke:#333,stroke-width:2px
    style CASP1 fill:#4a1a6b,stroke:#333,stroke-width:2px
    style IL18 fill:#4a1a6b,stroke:#333,stroke-width:2px
    style ATG7 fill:#4a1a6b,stroke:#333,stroke-width:2px
    style ATG5 fill:#4a1a6b,stroke:#333,stroke-width:2px
    style BECN1 fill:#4a1a6b,stroke:#333,stroke-width:2px

Outgoing (95)

Target	Relation	Type	Str
Aging	causes	disease	0.65
Als	causes	disease	0.65
Multiple Sclerosis	causes	disease	0.65
Neurodegeneration	inhibits	disease	0.65
Tumor	associated_with	disease	0.65
Pyroptosis	associated_with	disease	0.65
Dementia	associated_with	disease	0.65
Alzheimer	associated_with	disease	0.65
Aging	associated_with	disease	0.65
Alzheimer	regulates	disease	0.65
Als	regulates	disease	0.65
ALS	regulates	disease	0.65
Inflammation	contributes_to	disease	0.65
Neuroinflammation	activates	disease	0.65
Alzheimer	activates	disease	0.65
Als	expressed_in	disease	0.65
Pyroptosis	therapeutic_target	disease	0.65
Cancer	associated_with	disease	0.65
CASP1	inhibits	gene	0.60
ATG16L1	associated_with	gene	0.60
RB1CC1	associated_with	gene	0.60
ATG7	associated_with	gene	0.60
IL18	associated_with	gene	0.60
CASP6	associated_with	gene	0.60
PYCARD	associated_with	gene	0.60
BAX	associated_with	gene	0.60
GNB5	contributes_to	gene	0.60
SNCA	contributes_to	gene	0.60
ABCA1	contributes_to	gene	0.60
NLRP6	associated_with	gene	0.60
NLRP3	associated_with	gene	0.60
APP	contributes_to	gene	0.60
PARK7	contributes_to	gene	0.60
PSMB5	contributes_to	gene	0.60
SOCS3	expressed_in	gene	0.60
Rb	activates	protein	0.60
Nfkb	expressed_in	protein	0.60
Rb	associated_with	protein	0.60
CASP6	expressed_in	gene	0.60
NLRP6	expressed_in	gene	0.60
PYCARD	expressed_in	gene	0.60
MICROGLIA	causes	gene	0.60
Oxidative Stress	causes	pathway	0.60
Toll-Like Receptor	associated_with	pathway	0.60
Phagocytosis	associated_with	pathway	0.60
Apoptosis	associated_with	pathway	0.60
Autophagy	associated_with	pathway	0.60
DEMENTIA	associated_with	gene	0.60
Monocyte	associated_with	cell_type	0.60
Lipid Metabolism	contributes_to	pathway	0.60

Incoming (68)

Source	Relation	Type	Str
BECN1	associated_with	gene	0.60
ATG5	associated_with	gene	0.60
FIP200	associated_with	gene	0.60
RB1	associated_with	gene	0.60
IFNG	associated_with	gene	0.60
LC3	associated_with	gene	0.60
ATG14	associated_with	gene	0.60
MAP1LC3A	associated_with	gene	0.60
CASP1	associated_with	gene	0.60
TNF	associated_with	gene	0.60
TLR4	associated_with	gene	0.60
S100A8	associated_with	gene	0.60
NLRP6	associated_with	gene	0.60
NLRP3	associated_with	gene	0.60
PSMB5	contributes_to	gene	0.60
PARK7	contributes_to	gene	0.60
APP	contributes_to	gene	0.60
CASP6	associated_with	gene	0.60
BAX	associated_with	gene	0.60
PYCARD	associated_with	gene	0.60
ABCA1	contributes_to	gene	0.60
GNB5	contributes_to	gene	0.60
SNCA	contributes_to	gene	0.60
S100A8	expressed_in	gene	0.60
S100A9	expressed_in	gene	0.60
TFAM	activates	gene	0.60
OSMR	expressed_in	gene	0.60
DRP1	activates	gene	0.60
CASP9	biomarker_for	gene	0.60
CASP3	biomarker_for	gene	0.60
IL6	biomarker_for	gene	0.60
BAX	expressed_in	gene	0.60
NEURODEGENERATION	inhibits	gene	0.60
OXIDATIVE STRESS	causes	gene	0.60
AGING	causes	gene	0.60
GENES	associated_with	gene	0.60
PHAGOCYTOSIS	associated_with	gene	0.60
AUTOPHAGY	associated_with	gene	0.60
APOPTOSIS	associated_with	gene	0.60
PYROPTOSIS	associated_with	gene	0.60
ALZHEIMER	associated_with	gene	0.60
NEP	contributes_to	gene	0.60
PLAT	contributes_to	gene	0.60
ALZHEIMER	regulates	gene	0.60
AGING	associated_with	gene	0.60
DEMENTIA	associated_with	gene	0.60
GENES	contributes_to	gene	0.60
INFLAMMATION	contributes_to	gene	0.60
MICROGLIA	activates	gene	0.60
DNA	expressed_in	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

CASP4

Understanding Entity Pages

Summary

Wiki Pages (8)

CASP4 Gene

CASP12 (Caspase-12)

CASP14 Gene

GNB5 Gene

CASP4 Protein

PSMB5 Gene