protein

PSMB5

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PSMB5: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

70Connections

0Hypotheses

0Analyses

42Outgoing

28Incoming

Summary

Page for PSMB5 Protein

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🔬 Protein Info

Gene Symbol	PSMB5
Full Name	Proteasome Subunit Beta 5
Chromosome	14q11.2
Protein Type	Protease
Function	is a 28-subunit protease organized as a four-ring stack.
Molecular Weight	28.5 kDa
Amino Acids	262 aa
Pathways	Proteostasis, α-Synuclein Aggregation
UniProt ID	P28074
NCBI Gene ID	5693
Ensembl ID	ENSG00000100814
OMIM	177046
GeneCards	PSMB5
Human Protein Atlas	PSMB5
Associated Diseases	oxidative stress
Known Drugs/Compounds	rapamycin
Interactions	RPS6KB1, SQSTM1, TP53, SMAD, TGFB, ROS
KG Connections	70 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: PSMB5 — AlphaFold P28074 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    PSMB5["<b>PSMB5</b>"]
    Alzheimer["Alzheimer"]
    PSMB5 -->|"regulates"| Alzheimer
    Als["Als"]
    PSMB5 -->|"regulates"| Als
    ALS["ALS"]
    PSMB5 -->|"regulates"| ALS
    Inflammation["Inflammation"]
    PSMB5 -->|"contributes to"| Inflammation
    NEP["NEP"]
    PSMB5 -->|"contributes to"| NEP
    PARK7["PARK7"]
    PSMB5 -->|"contributes to"| PARK7
    PLAT["PLAT"]
    PSMB5 -->|"contributes to"| PLAT
    ALZHEIMER["ALZHEIMER"]
    PSMB5 -->|"regulates"| ALZHEIMER
    APP["APP"]
    PSMB5 -->|"contributes to"| APP
    CASP4["CASP4"]
    PSMB5 -->|"contributes to"| CASP4
    GNB5["GNB5"]
    PSMB5 -->|"contributes to"| GNB5
    SNCA["SNCA"]
    PSMB5 -->|"contributes to"| SNCA
    ABCA1["ABCA1"]
    PSMB5 -->|"contributes to"| ABCA1
    Lipid_Metabolism["Lipid Metabolism"]
    PSMB5 -->|"contributes to"| Lipid_Metabolism
    Neurogenesis["Neurogenesis"]
    PSMB5 -->|"contributes to"| Neurogenesis
    Oxidative_Stress["Oxidative Stress"]
    PSMB5 -->|"contributes to"| Oxidative_Stress
    GENES["GENES"]
    PSMB5 -->|"contributes to"| GENES
    INFLAMMATION["INFLAMMATION"]
    PSMB5 -->|"contributes to"| INFLAMMATION
    OXIDATIVE_STRESS["OXIDATIVE STRESS"]
    PSMB5 -->|"contributes to"| OXIDATIVE_STRESS
    AND["AND"]
    PSMB5 -->|"contributes to"| AND
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
    PSMB5 -->|"regulates"| ALZHEIMER_S_DISEASE
    NEURODEGENERATIVE_DISEASES["NEURODEGENERATIVE DISEASES"]
    PSMB5 -->|"regulates"| NEURODEGENERATIVE_DISEASES
    Ca1["Ca1"]
    PSMB5 -->|"expressed in"| Ca1
    neurodegeneration["neurodegeneration"]
    PSMB5 -->|"implicated in"| neurodegeneration

Outgoing (42)

Target	Relation	Type	Str
Alzheimer	regulates	disease	0.65
Als	regulates	disease	0.65
ALS	regulates	disease	0.65
Inflammation	contributes_to	disease	0.65
PARK7	contributes_to	gene	0.60
APP	contributes_to	gene	0.60
CASP4	contributes_to	gene	0.60
GNB5	contributes_to	gene	0.60
SNCA	contributes_to	gene	0.60
ABCA1	contributes_to	gene	0.60
RPS6KB1	activates	gene	0.60
SQSTM1	activates	gene	0.60
TP53	activates	gene	0.60
NEP	contributes_to	gene	0.60
PLAT	contributes_to	gene	0.60
ALZHEIMER	regulates	gene	0.60
Lipid Metabolism	contributes_to	pathway	0.60
Neurogenesis	contributes_to	pathway	0.60
Oxidative Stress	contributes_to	pathway	0.60
GENES	contributes_to	gene	0.60
INFLAMMATION	contributes_to	gene	0.60
OXIDATIVE STRESS	contributes_to	gene	0.60
AND	contributes_to	gene	0.60
ALZHEIMER'S DISEASE	regulates	gene	0.60
NEURODEGENERATIVE DISEASES	regulates	gene	0.60
SMAD	activates	gene	0.60
TGFB	activates	gene	0.60
Alzheimer's disease	activates	disease	0.60
Parkinson's disease	activates	disease	0.60
autophagy pathway	participates_in	pathway	0.60
oxidative stress response	participates_in	pathway	0.60
senescence	participates_in	pathway	0.60
ubiquitin-proteasome	participates_in	pathway	0.60
TGF-beta signaling	participates_in	pathway	0.60
ROS	activates	gene	0.60
PI3K-AKT-mTOR signaling	participates_in	pathway	0.60
Ca1	expressed_in	brain_region	0.55
CASP4	associated_with	protein	0.50
inflammation	associated_with	pathway	0.50
oxidative stress	associated_with	phenotype	0.50
LIPID METABOLISM	associated_with	pathway	0.50
Neurogenesis	associated_with	pathway	0.50

Incoming (28)

Source	Relation	Type	Str
PARK7	contributes_to	gene	0.60
ABCA1	contributes_to	gene	0.60
SNCA	contributes_to	gene	0.60
CASP4	contributes_to	gene	0.60
APP	contributes_to	gene	0.60
GNB5	contributes_to	gene	0.60
AKT	activates	gene	0.60
CDKN1A	activates	gene	0.60
CDKN2A	activates	gene	0.60
EIF4EBP1	activates	gene	0.60
GLB1	activates	gene	0.60
LC3	activates	gene	0.60
MKI67	activates	gene	0.60
MTOR	activates	gene	0.60
PI3K	activates	gene	0.60
PIK3CA	activates	gene	0.60
PSMA1	activates	gene	0.60
PLAT	contributes_to	gene	0.60
ALZHEIMER	regulates	gene	0.60
ATG	activates	gene	0.60
DMSO	activates	gene	0.60
MAP1LC3	activates	gene	0.60
PCNA	activates	gene	0.60
rapamycin	targets	drug	0.60
ABCA1	associated_with	gene	0.50
SNCA	associated_with	gene	0.50
PARK7	associated_with	gene	0.50
GNB5	associated_with	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

PSMB5

Understanding Entity Pages

Summary

Wiki Pages (21)

PSMB5 Gene

Sulforaphane and Nrf2 Activation for Neuroprotection

proteasome-ubiquitin-system-dysfunction-parkinsons

Reactive Oxygen Species (ROS) Pathway

Ubiquitin-Proteasome System Dysfunction in Alzheimer's Disease

Ubiquitin-Proteasome System Dysfunction in Corticobasal Syndrome

Advanced Proteolysis and Ubiquitin System Targeting in CBS/PSP

Proteasome Dysfunction in Progressive Supranuclear Palsy

26S Proteasome

Alzheimer's Disease Nrf2-Keap1 Pathway and Oxidative Stress Therapy Companies

PSMB9 Protein

NRF2 — Nuclear Factor Erythroid 2-Related Factor 2

NFE2L1 — Nuclear Factor Erythroid 2-Like 1

GLB1 Gene

PSMB7

PSMA1 Protein

GNB5 Gene

PSMA1 Gene

PSMB2 Gene