gene

GNB5

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GNB5: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

44Connections
0Hypotheses
0Analyses
29Outgoing
15Incoming

Summary

Page for GNB5 Gene

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🧬 Gene Info
Gene SymbolGNB5
Full NameGNB5
Chromosome15q21.1
Protein TypeGene
Functionencodes a brain-specific G protein beta subunit that plays critical roles in neuronal GPCR signaling.
Molecular Weight37.5 kDa
Amino Acids395 aa
Exons12
NCBI Gene IDSearch NCBI
GeneCardsGNB5
Human Protein AtlasGNB5
Associated Diseasesoxidative stress
InteractionsRGS
KG Connections44 knowledge graph edges
DatabasesGeneCardsUniProtHPASTRING

Wiki Pages (11)

Knowledge base pages for this entity

Canonical Page

GNB5 Gene

gene · 988 words

GNG3 Protein

protein · 1874 words

GNB5 (G Protein Subunit Beta 5)

protein · 1749 words

GNB4 Gene — G Protein Subunit Beta 4

gene · 1675 words

RGS7 Gene

gene · 1027 words

PSMB5 Gene

gene · 726 words

Pathway Diagram

graph TD
    GNB5["<b>GNB5</b>"]
    AKT["AKT"]
    GNB5 -->|"regulates"| AKT
    NF__B["NF-kappaB"]
    GNB5 -->|"regulates"| NF__B
    Apoptosis["Apoptosis"]
    GNB5 -->|"regulates"| Apoptosis
    CX3CL1["CX3CL1"]
    CX3CL1 -->|"regulates"| GNB5
    RGS["RGS"]
    GNB5 -->|"interacts with"| RGS
    Alzheimer["Alzheimer"]
    GNB5 -->|"regulates"| Alzheimer
    Als["Als"]
    GNB5 -->|"regulates"| Als
    ALS["ALS"]
    GNB5 -->|"regulates"| ALS
    Inflammation["Inflammation"]
    GNB5 -->|"contributes to"| Inflammation
    SNCA["SNCA"]
    GNB5 -->|"contributes to"| SNCA
    ABCA1["ABCA1"]
    GNB5 -->|"contributes to"| ABCA1
    Lipid_Metabolism["Lipid Metabolism"]
    GNB5 -->|"contributes to"| Lipid_Metabolism
    Neurogenesis["Neurogenesis"]
    GNB5 -->|"contributes to"| Neurogenesis
    Oxidative_Stress["Oxidative Stress"]
    GNB5 -->|"contributes to"| Oxidative_Stress
    OXIDATIVE_STRESS["OXIDATIVE STRESS"]
    GNB5 -->|"contributes to"| OXIDATIVE_STRESS
    NEP["NEP"]
    GNB5 -->|"contributes to"| NEP
    AND["AND"]
    GNB5 -->|"contributes to"| AND
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
    GNB5 -->|"regulates"| ALZHEIMER_S_DISEASE
    NEURODEGENERATIVE_DISEASES["NEURODEGENERATIVE DISEASES"]
    GNB5 -->|"regulates"| NEURODEGENERATIVE_DISEASES
    PLAT["PLAT"]
    GNB5 -->|"contributes to"| PLAT
    PARK7["PARK7"]
    GNB5 -->|"contributes to"| PARK7
    PSMB5["PSMB5"]
    PSMB5 -->|"contributes to"| GNB5
    NEP["NEP"]
    NEP -->|"contributes to"| GNB5
    PARK7["PARK7"]
    PARK7 -->|"contributes to"| GNB5
    PLAT["PLAT"]
    PLAT -->|"contributes to"| GNB5
    ALZHEIMER["ALZHEIMER"]
    ALZHEIMER -->|"regulates"| GNB5
    APP["APP"]
    APP -->|"contributes to"| GNB5
    CASP4["CASP4"]
    CASP4 -->|"contributes to"| GNB5
    GENES["GENES"]
    GENES -->|"contributes to"| GNB5
    INFLAMMATION["INFLAMMATION"]
    INFLAMMATION -->|"contributes to"| GNB5

Outgoing (29)

TargetRelationTypeStr
AKTregulatesprotein0.80
RGSinteracts_withprotein0.70
Alzheimerregulatesdisease0.65
Alsregulatesdisease0.65
ALSregulatesdisease0.65

Incoming (15)

SourceRelationTypeStr
CX3CL1regulatesprotein0.80
PSMB5contributes_togene0.60
PARK7contributes_togene0.60
APPcontributes_togene0.60
CASP4contributes_togene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found