Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about GNB5: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Gene Symbol | GNB5 |
| Full Name | GNB5 |
| Chromosome | 15q21.1 |
| Protein Type | Gene |
| Function | encodes a brain-specific G protein beta subunit that plays critical roles in neuronal GPCR signaling. |
| Molecular Weight | 37.5 kDa |
| Amino Acids | 395 aa |
| Exons | 12 |
| NCBI Gene ID | Search NCBI |
| GeneCards | GNB5 |
| Human Protein Atlas | GNB5 |
| Associated Diseases | oxidative stress |
| Interactions | RGS |
| KG Connections | 44 knowledge graph edges |
| Databases | GeneCardsUniProtHPASTRING |
Knowledge base pages for this entity
graph TD
GNB5["<b>GNB5</b>"]
AKT["AKT"]
GNB5 -->|"regulates"| AKT
NF__B["NF-kappaB"]
GNB5 -->|"regulates"| NF__B
Apoptosis["Apoptosis"]
GNB5 -->|"regulates"| Apoptosis
CX3CL1["CX3CL1"]
CX3CL1 -->|"regulates"| GNB5
RGS["RGS"]
GNB5 -->|"interacts with"| RGS
Alzheimer["Alzheimer"]
GNB5 -->|"regulates"| Alzheimer
Als["Als"]
GNB5 -->|"regulates"| Als
ALS["ALS"]
GNB5 -->|"regulates"| ALS
Inflammation["Inflammation"]
GNB5 -->|"contributes to"| Inflammation
SNCA["SNCA"]
GNB5 -->|"contributes to"| SNCA
ABCA1["ABCA1"]
GNB5 -->|"contributes to"| ABCA1
Lipid_Metabolism["Lipid Metabolism"]
GNB5 -->|"contributes to"| Lipid_Metabolism
Neurogenesis["Neurogenesis"]
GNB5 -->|"contributes to"| Neurogenesis
Oxidative_Stress["Oxidative Stress"]
GNB5 -->|"contributes to"| Oxidative_Stress
OXIDATIVE_STRESS["OXIDATIVE STRESS"]
GNB5 -->|"contributes to"| OXIDATIVE_STRESS
NEP["NEP"]
GNB5 -->|"contributes to"| NEP
AND["AND"]
GNB5 -->|"contributes to"| AND
ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
GNB5 -->|"regulates"| ALZHEIMER_S_DISEASE
NEURODEGENERATIVE_DISEASES["NEURODEGENERATIVE DISEASES"]
GNB5 -->|"regulates"| NEURODEGENERATIVE_DISEASES
PLAT["PLAT"]
GNB5 -->|"contributes to"| PLAT
PARK7["PARK7"]
GNB5 -->|"contributes to"| PARK7
PSMB5["PSMB5"]
PSMB5 -->|"contributes to"| GNB5
NEP["NEP"]
NEP -->|"contributes to"| GNB5
PARK7["PARK7"]
PARK7 -->|"contributes to"| GNB5
PLAT["PLAT"]
PLAT -->|"contributes to"| GNB5
ALZHEIMER["ALZHEIMER"]
ALZHEIMER -->|"regulates"| GNB5
APP["APP"]
APP -->|"contributes to"| GNB5
CASP4["CASP4"]
CASP4 -->|"contributes to"| GNB5
GENES["GENES"]
GENES -->|"contributes to"| GNB5
INFLAMMATION["INFLAMMATION"]
INFLAMMATION -->|"contributes to"| GNB5| Target | Relation | Type | Str |
|---|---|---|---|
| AKT | regulates | protein | 0.80 |
| RGS | interacts_with | protein | 0.70 |
| Alzheimer | regulates | disease | 0.65 |
| Als | regulates | disease | 0.65 |
| ALS | regulates | disease | 0.65 |
| Inflammation | contributes_to | disease | 0.65 |
| SNCA | contributes_to | gene | 0.60 |
| ABCA1 | contributes_to | gene | 0.60 |
| PARK7 | contributes_to | gene | 0.60 |
| CASP4 | contributes_to | gene | 0.60 |
| APP | contributes_to | gene | 0.60 |
| PSMB5 | contributes_to | gene | 0.60 |
| Lipid Metabolism | contributes_to | pathway | 0.60 |
| Neurogenesis | contributes_to | pathway | 0.60 |
| Oxidative Stress | contributes_to | pathway | 0.60 |
| OXIDATIVE STRESS | contributes_to | gene | 0.60 |
| NEP | contributes_to | gene | 0.60 |
| AND | contributes_to | gene | 0.60 |
| ALZHEIMER'S DISEASE | regulates | gene | 0.60 |
| NEURODEGENERATIVE DISEASES | regulates | gene | 0.60 |
| PLAT | contributes_to | gene | 0.60 |
| App | contributes_to | protein | 0.60 |
| Ca1 | expressed_in | brain_region | 0.55 |
| PSMB5 | associated_with | protein | 0.50 |
| CASP4 | associated_with | protein | 0.50 |
| inflammation | associated_with | pathway | 0.50 |
| oxidative stress | associated_with | phenotype | 0.50 |
| LIPID METABOLISM | associated_with | pathway | 0.50 |
| Neurogenesis | associated_with | pathway | 0.50 |
| Source | Relation | Type | Str |
|---|---|---|---|
| CX3CL1 | regulates | protein | 0.80 |
| PSMB5 | contributes_to | gene | 0.60 |
| PARK7 | contributes_to | gene | 0.60 |
| APP | contributes_to | gene | 0.60 |
| CASP4 | contributes_to | gene | 0.60 |
| ABCA1 | contributes_to | gene | 0.60 |
| SNCA | contributes_to | gene | 0.60 |
| NEP | contributes_to | gene | 0.60 |
| PLAT | contributes_to | gene | 0.60 |
| ALZHEIMER | regulates | gene | 0.60 |
| GENES | contributes_to | gene | 0.60 |
| INFLAMMATION | contributes_to | gene | 0.60 |
| ABCA1 | associated_with | gene | 0.50 |
| SNCA | associated_with | gene | 0.50 |
| PARK7 | associated_with | gene | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||