concept

NEP

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NEP: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

120Connections

0Hypotheses

0Analyses

50Outgoing

43Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	NEP
Key Genes/Proteins	amyloid-beta, irisin, AND, APP/PS1, ALZHEIMER'S DISEASE
Related Diseases	Alzheimer, ALS, Als, Neurodegeneration, Inflammation

Wiki Pages (15)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    NEP["NEP"]
    NEP -->|"catalyzes"| AMYLOID_BETA["AMYLOID BETA"]
    NEP -.protects against.-> Alzheimer_s_Disease["Alzheimer's Disease"]
    NEP -->|"regulates"| amyloid_beta["amyloid-beta"]
    NEP -->|"activates"| Alzheimer["Alzheimer"]
    NEP -->|"expressed in"| ALS["ALS"]
    NEP -->|"expressed in"| Als["Als"]
    NEP -->|"activates"| Neurodegeneration["Neurodegeneration"]
    AHR["AHR"] -->|"upregulates"| NEP
    irisin["irisin"] -->|"activates"| NEP
    NEPRILYSIN["NEPRILYSIN"] -->|"activates"| NEP
    ALZHEIMER["ALZHEIMER"] -->|"activates"| NEP
    APP["APP"] -->|"activates"| NEP
    EXERCISE["EXERCISE"] -->|"inhibits"| NEP

Outgoing (77)

Target	Relation	Type	Str
amyloid-beta	regulates	protein	0.70
Alzheimer	activates	disease	0.65
ALS	expressed_in	disease	0.65
Alzheimer	inhibits	disease	0.65
Als	expressed_in	disease	0.65
Neurodegeneration	activates	disease	0.65
Alzheimer	associated_with	disease	0.65
Alzheimer	regulates	disease	0.65
Als	regulates	disease	0.65
ALS	regulates	disease	0.65
Inflammation	contributes_to	disease	0.65
AND	activates	gene	0.60
APP/PS1	activates	gene	0.60
ALZHEIMER'S DISEASE	activates	gene	0.60
AMYLOID	associated_with	gene	0.60
Amyloid	associated_with	pathway	0.60
STAT3	inhibits	gene	0.60
AND	inhibits	gene	0.60
ASTROCYTES	activates	gene	0.60
ALZHEIMER'S DISEASE	inhibits	gene	0.60
ERK	inhibits	gene	0.60
AMYLOID	inhibits	gene	0.60
Amyloid	inhibits	pathway	0.60
ALZHEIMER	activates	gene	0.60
NEPRILYSIN	activates	gene	0.60
AHR	activates	gene	0.60
ALZHEIMER	inhibits	gene	0.60
FNDC5	inhibits	gene	0.60
NEPRILYSIN	inhibits	gene	0.60
EXERCISE	inhibits	gene	0.60
Astrocyte	activates	cell_type	0.60
APOPTOSIS	activates	gene	0.60
TAU	activates	gene	0.60
ACE2	activates	gene	0.60
IDE	activates	gene	0.60
Apoptosis	activates	pathway	0.60
PER	inhibits	gene	0.60
NEPRILYSIN	associated_with	gene	0.60
Blood-Brain Barrier	activates	pathway	0.60
PARK7	regulates	gene	0.60
PLAT	contributes_to	gene	0.60
ALZHEIMER	regulates	gene	0.60
APP	contributes_to	gene	0.60
CASP4	contributes_to	gene	0.60
GNB5	contributes_to	gene	0.60
SNCA	contributes_to	gene	0.60
ABCA1	contributes_to	gene	0.60
Lipid Metabolism	contributes_to	pathway	0.60
Neurogenesis	contributes_to	pathway	0.60
Oxidative Stress	contributes_to	pathway	0.60

Incoming (43)

Source	Relation	Type	Str
irisin	activates	protein	0.70
AHR	activates	gene	0.60
NEPRILYSIN	activates	gene	0.60
ALZHEIMER	activates	gene	0.60
APP	activates	gene	0.60
EXERCISE	inhibits	gene	0.60
NEPRILYSIN	inhibits	gene	0.60
FNDC5	inhibits	gene	0.60
ALZHEIMER	inhibits	gene	0.60
ALZHEIMER	associated_with	gene	0.60
PSMB5	contributes_to	gene	0.60
NEURODEGENERATION	activates	gene	0.60
AMYLOID	associated_with	gene	0.60
APOPTOSIS	activates	gene	0.60
PER	inhibits	gene	0.60
NEPRILYSIN	degrades	gene	0.60
GENES	regulates	gene	0.60
INFLAMMATION	contributes_to	gene	0.60
CASP4	contributes_to	gene	0.60
ALZHEIMER	regulates	gene	0.60
APP	contributes_to	gene	0.60
GNB5	contributes_to	gene	0.60
SNCA	contributes_to	gene	0.60
OXIDATIVE STRESS	contributes_to	gene	0.60
ALZHEIMER'S DISEASE	activates	gene	0.60
ERK	inhibits	gene	0.60
ALZHEIMER'S DISEASE	inhibits	gene	0.60
STAT3	inhibits	gene	0.60
APP/PS1	activates	gene	0.60
TAU	activates	gene	0.60
ACE2	activates	gene	0.60
PLAT	contributes_to	gene	0.60
PARK7	regulates	gene	0.60
ABCA1	contributes_to	gene	0.60
ASTROCYTES	activates	gene	0.60
IDE	activates	gene	0.60
APP	associated_with	gene	0.60
ACE2	associated_with	gene	0.60
IDE	associated_with	gene	0.60
ACE2	expressed_in	gene	0.60
IDE	expressed_in	gene	0.60
IDE	protects_against	gene	0.60
IDE	cleaves	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

NEP

Understanding Entity Pages

Wiki Pages (15)

Amyloid Cascade Pathway

Arsenic Exposure and Alzheimer's Disease Mechanism

Neprilysin (NEP / CD10 / MME)

Amyloid-Beta (Aβ)

MME (Membrane Metalloendopeptidase / Neprilysin)

Neural Circuits in Dementia with Lewy Bodies

Amyloid Clearance Mechanisms

Amyloid-Beta Clearance Therapeutic Pathways

Amyloid-beta Degradation Pathways

ACE Protein

Neprilysin (NEP)

Entities

MME Protein (Neprilysin/CD10)