gene

RNF5

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about RNF5: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

24Connections

0Hypotheses

0Analyses

15Outgoing

9Incoming

Summary

RING finger E3 ubiquitin ligase involved in ERAD and protein quality control

View on Wiki →

🧬 Gene Info

Gene Symbol	RNF5
Full Name	RING Finger Protein 5
Chromosome	6p21.33
Protein Family	RING finger E3 ubiquitin ligase family
Protein Type	Ligase
Function	is a RING-type E3 ubiquitin ligase localized primarily to the endoplasmic reticulum (ER) membrane.
Primary Expression	virtually all human tissues with highest levels in: - Brain: Cerebral cortex, hippocampus, substantia nigra, cerebellum - Heart: Myocardium, c
Amino Acids	180 aa
Exons	4
Pathways	Immune Response
UniProt ID	[Q99969](https://www.uniprot.org/uniprot/Q99969)
Ensembl ID	ENSG00000243156
OMIM	603419
GeneCards	RNF5
Human Protein Atlas	RNF5
Associated Diseases	neurodegeneration
KG Connections	24 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (4)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    RNF5["<b>RNF5</b>"]
    Fibrosis{"Fibrosis"}
    RNF5 -->|"regulates"| Fibrosis
    NBR1["NBR1"]
    RNF5 -->|"contributes to"| NBR1
    BRCA1["BRCA1"]
    RNF5 -->|"regulates"| BRCA1
    AUTOPHAGY["AUTOPHAGY"]
    RNF5 -->|"contributes to"| AUTOPHAGY
    Autophagy(["Autophagy"])
    RNF5 -->|"contributes to"| Autophagy
    Immune_Response(["Immune Response"])
    RNF5 -->|"regulates"| Immune_Response
    CFTR["CFTR"]
    RNF5 -->|"regulates"| CFTR
    UBIQUITIN["UBIQUITIN"]
    RNF5 -->|"associated with"| UBIQUITIN
    neurodegeneration["neurodegeneration"]
    RNF5 -->|"implicated in"| neurodegeneration
    MAVS["MAVS"]
    MAVS -->|"contributes to"| RNF5
    style RNF5 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (15)

Target	Relation	Type	Str
Fibrosis	regulates	disease	0.65
Tumor	expressed_in	disease	0.65
Colorectal Cancer	therapeutic_target	disease	0.65
Cancer	expressed_in	disease	0.65
Liver Cancer	expressed_in	disease	0.65
Als	therapeutic_target	disease	0.65
Infection	regulates	disease	0.65
NBR1	contributes_to	gene	0.60
BRCA1	regulates	gene	0.60
CFTR	regulates	gene	0.60
UBIQUITIN	associated_with	gene	0.60
AUTOPHAGY	contributes_to	gene	0.60
Autophagy	contributes_to	pathway	0.60
Immune Response	regulates	pathway	0.60
IFN	regulates	gene	0.60

Incoming (9)

Source	Relation	Type	Str
MAVS	contributes_to	gene	0.60
PINK1	therapeutic_target	gene	0.60
DOCK2	therapeutic_target	gene	0.60
LRPPRC	therapeutic_target	gene	0.60
HERC5	expressed_in	gene	0.60
UBIQUITIN	expressed_in	gene	0.60
BRCA1	regulates	gene	0.60
CANCER	expressed_in	gene	0.60
AND	contributes_to	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found