Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about LRPPRC: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
LRPPRC in mitochondrial mRNA processing, Leigh syndrome French-Canadian type and neurodegeneration
| Gene Symbol | LRPPRC |
| Full Name | Leucine-Rich Pentatricopeptide Repeat Containing |
| Chromosome | 2p21 |
| Function | LRPPRC encodes a leucine-rich pentatricopeptide repeat (PPR) protein that localizes to mitochondria and is involved in post-transcriptional regulation of mitochondrial gene expression. |
| Primary Expression | High in tissues with high mitochondrial content: brain, heart, skeletal muscle, kidney |
| Molecular Weight | ~156 kDa |
| Amino Acids | 394 aa |
| Exons | 38 |
| Pathways | Oxidative Phosphorylation |
| UniProt ID | Q9GZL0 |
| NCBI Gene ID | 90333 |
| Ensembl ID | ENSG00000138095 |
| OMIM | 607544 |
| GeneCards | LRPPRC |
| Human Protein Atlas | LRPPRC |
| Associated Diseases | Als, Parkinson |
| Known Drugs/Compounds | Duloxetine, Donepezil, donepezil |
| Interactions | ACO2, HSPA9, SNCA, SDHA, VDAC1, CYCS |
| KG Connections | 106 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
LRPPRC["<b>LRPPRC</b>"]
BECN1["BECN1"]
LRPPRC -->|"interacts with"| BECN1
Parkinson{"Parkinson"}
LRPPRC -->|"therapeutic target"| Parkinson
OXIDATIVE_STRESS["OXIDATIVE STRESS"]
LRPPRC -->|"therapeutic target"| OXIDATIVE_STRESS
NDUFS2["NDUFS2"]
LRPPRC -->|"associated with"| NDUFS2
NDUFS1["NDUFS1"]
LRPPRC -->|"associated with"| NDUFS1
SDHA["SDHA"]
LRPPRC -->|"therapeutic target"| SDHA
Oxidative_Phosphorylation(["Oxidative Phosphorylation"])
LRPPRC -->|"therapeutic target"| Oxidative_Phosphorylation
Oxidative_Stress(["Oxidative Stress"])
LRPPRC -->|"therapeutic target"| Oxidative_Stress
LRPPRC -->|"expressed in"| Oxidative_Phosphorylation
neurodegeneration["neurodegeneration"]
LRPPRC -->|"implicated in"| neurodegeneration
NS1["NS1"]
NS1 -->|"interacts with"| LRPPRC
PARKINSON_S_DISEASE["PARKINSON'S DISEASE"]
PARKINSON_S_DISEASE -->|"therapeutic target"| LRPPRC
VDAC1["VDAC1"]
VDAC1 -->|"therapeutic target"| LRPPRC
HSPA9["HSPA9"]
HSPA9 -->|"therapeutic target"| LRPPRC
CYCS["CYCS"]
CYCS -->|"therapeutic target"| LRPPRC
IMMUNE_INFILTRATION["IMMUNE INFILTRATION"]
IMMUNE_INFILTRATION -->|"therapeutic target"| LRPPRC
ACO2["ACO2"]
ACO2 -->|"therapeutic target"| LRPPRC
GLUD1["GLUD1"]
GLUD1 -->|"associated with"| LRPPRC
SNCA["SNCA"]
SNCA -->|"therapeutic target"| LRPPRC
style LRPPRC fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| BECN1 | interacts_with | protein | 0.90 |
| Oxidative Phosphorylation | involved_in | process | 0.80 |
| Parkinson | therapeutic_target | disease | 0.65 |
| Tumor | therapeutic_target | disease | 0.65 |
| Colorectal Cancer | therapeutic_target | disease | 0.65 |
| Cancer | therapeutic_target | disease | 0.65 |
| Liver Cancer | therapeutic_target | disease | 0.65 |
| Als | therapeutic_target | disease | 0.65 |
| Als | associated_with | disease | 0.65 |
| Parkinson | activates | disease | 0.65 |
| ALS | stabilizes | disease | 0.65 |
| Als | stabilizes | disease | 0.65 |
| NDUFS2 | associated_with | gene | 0.60 |
| NDUFS1 | associated_with | gene | 0.60 |
| SDHA | therapeutic_target | gene | 0.60 |
| HERC5 | therapeutic_target | gene | 0.60 |
| UBIQUITIN | therapeutic_target | gene | 0.60 |
| RNF5 | therapeutic_target | gene | 0.60 |
| ACO2 | therapeutic_target | gene | 0.60 |
| NDUFS2 | causes | gene | 0.60 |
| GLUD1 | causes | gene | 0.60 |
| VDAC1 | therapeutic_target | gene | 0.60 |
| mitoribosome | interacts_with | protein | 0.60 |
| SLIRP | interacts_with | protein | 0.60 |
| ACO2 | activates | gene | 0.60 |
| HSPA9 | activates | gene | 0.60 |
| NDUFS1 | causes | gene | 0.60 |
| SNCA | activates | gene | 0.60 |
| SDHA | activates | gene | 0.60 |
| VDAC1 | activates | gene | 0.60 |
| CYCS | activates | gene | 0.60 |
| HSPA9 | therapeutic_target | gene | 0.60 |
| CYCS | therapeutic_target | gene | 0.60 |
| SNCA | therapeutic_target | gene | 0.60 |
| OXIDATIVE STRESS | therapeutic_target | gene | 0.60 |
| Oxidative Phosphorylation | therapeutic_target | pathway | 0.60 |
| Oxidative Stress | therapeutic_target | pathway | 0.60 |
| Oxidative Phosphorylation | expressed_in | pathway | 0.60 |
| Autophagy | activates | pathway | 0.60 |
| CANCER | therapeutic_target | gene | 0.60 |
| AUTOPHAGY | activates | gene | 0.60 |
| ROS | therapeutic_target | gene | 0.60 |
| AND | interacts_with | gene | 0.60 |
| PARKINSON'S DISEASE | therapeutic_target | gene | 0.60 |
| PARKINSON | therapeutic_target | gene | 0.60 |
| T Cell | therapeutic_target | cell_type | 0.60 |
| Neuron | therapeutic_target | cell_type | 0.60 |
| HUB GENES | activates | gene | 0.60 |
| OXIDATIVE STRESS | activates | gene | 0.60 |
| ROS | activates | gene | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| NS1 | interacts_with | protein | 0.90 |
| Duloxetine | binds | drug | 0.75 |
| Donepezil | binds | drug | 0.75 |
| VDAC1 | therapeutic_target | gene | 0.60 |
| HSPA9 | therapeutic_target | gene | 0.60 |
| CYCS | therapeutic_target | gene | 0.60 |
| ACO2 | therapeutic_target | gene | 0.60 |
| GLUD1 | associated_with | gene | 0.60 |
| SNCA | therapeutic_target | gene | 0.60 |
| PINK1 | associated_with | gene | 0.60 |
| DOCK2 | associated_with | gene | 0.60 |
| NDUFS1 | causes | gene | 0.60 |
| GLUD1 | causes | gene | 0.60 |
| SDHA | therapeutic_target | gene | 0.60 |
| NDUFS2 | causes | gene | 0.60 |
| donepezil | targets | drug | 0.60 |
| PARKINSON'S DISEASE | therapeutic_target | gene | 0.60 |
| IMMUNE INFILTRATION | therapeutic_target | gene | 0.60 |
| AUTOPHAGY | activates | gene | 0.60 |
| AND | activates | gene | 0.60 |
| OXIDATIVE STRESS | therapeutic_target | gene | 0.60 |
| GENES | therapeutic_target | gene | 0.60 |
| ATP | therapeutic_target | gene | 0.60 |
| ROS | therapeutic_target | gene | 0.60 |
| PARKINSON | therapeutic_target | gene | 0.60 |
| MITOCHONDRIA | regulates | gene | 0.60 |
| RNA | interacts_with | gene | 0.60 |
| AND | interacts_with | gene | 0.60 |
| GLUD1 | co_expressed_with | gene | 0.50 |
| HSPA9 | co_expressed_with | gene | 0.50 |
| MITOCHONDRIA | associated_with | cell_type | 0.50 |
| MITOCHONDRIA | interacts_with | cell_type | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||