gene

LRPPRC

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about LRPPRC: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

106Connections
0Hypotheses
0Analyses
50Outgoing
32Incoming

Summary

LRPPRC in mitochondrial mRNA processing, Leigh syndrome French-Canadian type and neurodegeneration

View on Wiki →

🧬 Gene Info
Gene SymbolLRPPRC
Full NameLeucine-Rich Pentatricopeptide Repeat Containing
Chromosome2p21
FunctionLRPPRC encodes a leucine-rich pentatricopeptide repeat (PPR) protein that localizes to mitochondria and is involved in post-transcriptional regulation of mitochondrial gene expression.
Primary ExpressionHigh in tissues with high mitochondrial content: brain, heart, skeletal muscle, kidney
Molecular Weight~156 kDa
Amino Acids394 aa
Exons38
PathwaysOxidative Phosphorylation
UniProt IDQ9GZL0
NCBI Gene ID90333
Ensembl IDENSG00000138095
OMIM607544
GeneCardsLRPPRC
Human Protein AtlasLRPPRC
Associated DiseasesAls, Parkinson
Known Drugs/CompoundsDuloxetine, Donepezil, donepezil
InteractionsACO2, HSPA9, SNCA, SDHA, VDAC1, CYCS
KG Connections106 knowledge graph edges
DatabasesGeneCardsHPASTRING

Wiki Pages (13)

Knowledge base pages for this entity

Canonical Page

LRPPRC — Leucine-Rich Pentatricopeptide Repeat Containing

gene · 1293 words

herc5

gene · 2524 words

LRPPRC Protein

protein · 2294 words

COX4I1

gene · 1587 words

NDUFS3 Gene - NADH:Ubiquinone Oxidoreductase Core Subunit S3

gene · 1476 words

DARS2 Protein

protein · 1185 words

Pathway Diagram

graph TD
    LRPPRC["<b>LRPPRC</b>"]
    BECN1["BECN1"]
    LRPPRC -->|"interacts with"| BECN1
    Parkinson{"Parkinson"}
    LRPPRC -->|"therapeutic target"| Parkinson
    OXIDATIVE_STRESS["OXIDATIVE STRESS"]
    LRPPRC -->|"therapeutic target"| OXIDATIVE_STRESS
    NDUFS2["NDUFS2"]
    LRPPRC -->|"associated with"| NDUFS2
    NDUFS1["NDUFS1"]
    LRPPRC -->|"associated with"| NDUFS1
    SDHA["SDHA"]
    LRPPRC -->|"therapeutic target"| SDHA
    Oxidative_Phosphorylation(["Oxidative Phosphorylation"])
    LRPPRC -->|"therapeutic target"| Oxidative_Phosphorylation
    Oxidative_Stress(["Oxidative Stress"])
    LRPPRC -->|"therapeutic target"| Oxidative_Stress
    LRPPRC -->|"expressed in"| Oxidative_Phosphorylation
    neurodegeneration["neurodegeneration"]
    LRPPRC -->|"implicated in"| neurodegeneration
    NS1["NS1"]
    NS1 -->|"interacts with"| LRPPRC
    PARKINSON_S_DISEASE["PARKINSON'S DISEASE"]
    PARKINSON_S_DISEASE -->|"therapeutic target"| LRPPRC
    VDAC1["VDAC1"]
    VDAC1 -->|"therapeutic target"| LRPPRC
    HSPA9["HSPA9"]
    HSPA9 -->|"therapeutic target"| LRPPRC
    CYCS["CYCS"]
    CYCS -->|"therapeutic target"| LRPPRC
    IMMUNE_INFILTRATION["IMMUNE INFILTRATION"]
    IMMUNE_INFILTRATION -->|"therapeutic target"| LRPPRC
    ACO2["ACO2"]
    ACO2 -->|"therapeutic target"| LRPPRC
    GLUD1["GLUD1"]
    GLUD1 -->|"associated with"| LRPPRC
    SNCA["SNCA"]
    SNCA -->|"therapeutic target"| LRPPRC
    style LRPPRC fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (74)

TargetRelationTypeStr
BECN1interacts_withprotein0.90
Oxidative Phosphorylationinvolved_inprocess0.80
Parkinsontherapeutic_targetdisease0.65
Tumortherapeutic_targetdisease0.65
Colorectal Cancertherapeutic_targetdisease0.65

Incoming (32)

SourceRelationTypeStr
NS1interacts_withprotein0.90
Duloxetinebindsdrug0.75
Donepezilbindsdrug0.75
VDAC1therapeutic_targetgene0.60
HSPA9therapeutic_targetgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found