gene

HERC5

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about HERC5: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

79Connections

0Hypotheses

0Analyses

50Outgoing

27Incoming

Summary

HERC5 is a gene implicated in neurodegeneration research. Key relationships include: expressed in, therapeutic target, activates. Associated with Als, Cancer, Colorectal Cancer. Connected to 17 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	HERC5
Protein Type	Ligase
Function	ISG15 is a 165-amino acid ubiquitin-like protein that can be covalently attached to lysine residues on substrate proteins.
Subcellular Localization	HERC5 is primarily localized to the:
Amino Acids	693 aa
Exons	22
Pathways	Apoptosis, Immune Response, Innate Immunity, Mtor, Nf-Κb
Ensembl ID	ENSG00000138617
GeneCards	HERC5
Human Protein Atlas	HERC5
N-terminal RCC1-like domain (RLD)	Contains multiple RCC1 repeats that function as guanine nucleotide exchange factors for small GTPases
HECT domain	The catalytic E3 ubiquitin ligase domain at the C-terminus (~350 amino acids)
Multiple WD40 repeats	Involved in protein-protein interactions
Flexible linker regions	Connect the various domains
Cytoplasm	Major site of ISG15 conjugation activity
Associated Diseases	neurodegeneration
Interactions	MAVS, MUL1, UBIQUITIN, DRP1, AUTOPHAGY, Ras
KG Connections	79 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (9)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    HERC5["<b>HERC5</b>"]
    Als{"Als"}
    HERC5 -->|"activates"| Als
    MAVS["MAVS"]
    HERC5 -->|"activates"| MAVS
    MUL1["MUL1"]
    HERC5 -->|"activates"| MUL1
    Innate_Immunity(["Innate Immunity"])
    HERC5 -->|"activates"| Innate_Immunity
    Immune_Response(["Immune Response"])
    HERC5 -->|"activates"| Immune_Response
    neurodegeneration["neurodegeneration"]
    HERC5 -->|"implicated in"| neurodegeneration
    style HERC5 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (52)

Target	Relation	Type	Str
Als	activates	disease	0.65
Tumor	expressed_in	disease	0.65
Colorectal Cancer	therapeutic_target	disease	0.65
Cancer	expressed_in	disease	0.65
Liver Cancer	expressed_in	disease	0.65
Als	therapeutic_target	disease	0.65
Cancer	activates	disease	0.65
Aging	activates	disease	0.65
Cancer	inhibits	disease	0.65
Als	interacts_with	disease	0.65
Als	contributes_to	disease	0.65
MAVS	activates	gene	0.60
MUL1	activates	gene	0.60
UBIQUITIN	expressed_in	gene	0.60
RNF5	expressed_in	gene	0.60
Rb	causes	protein	0.60
UBIQUITIN	activates	gene	0.60
DRP1	activates	gene	0.60
TRIM25	regulates	gene	0.60
HERC6	contributes_to	gene	0.60
UBIQUITIN	contributes_to	gene	0.60
HERC3	contributes_to	gene	0.60
ISG15	therapeutic_target	gene	0.60
UBIQUITIN	therapeutic_target	gene	0.60
Rb	therapeutic_target	protein	0.60
Innate Immunity	activates	pathway	0.60
Immune Response	activates	pathway	0.60
CANCER	expressed_in	gene	0.60
Ubiquitin	degrades	protein	0.60
AUTOPHAGY	activates	gene	0.60
Mtor	activates	pathway	0.60
Ras	activates	protein	0.60
App	activates	protein	0.60
T Cell	regulates	cell_type	0.60
Ubiquitin	regulates	protein	0.60
Raf	activates	protein	0.60
LGALS9	interacts_with	gene	0.60
Pi3K/Akt	activates	pathway	0.60
Akt	activates	protein	0.60
Pi3K	activates	protein	0.60
Nf-Κb	activates	pathway	0.60
MITOCHONDRIA	activates	gene	0.60
ALZHEIMER	regulates	gene	0.60
Fus	regulates	protein	0.60
Immune Response	contributes_to	pathway	0.60
T Cell	contributes_to	cell_type	0.60
Proteasome	contributes_to	protein	0.60
Ras	therapeutic_target	protein	0.60
Fus	therapeutic_target	protein	0.60
App	therapeutic_target	protein	0.60

Incoming (27)

Source	Relation	Type	Str
PINK1	therapeutic_target	gene	0.60
DOCK2	therapeutic_target	gene	0.60
LRPPRC	therapeutic_target	gene	0.60
HERC6	degrades	gene	0.60
STING	degrades	gene	0.60
MTOR	activates	gene	0.60
YBX1	regulates	gene	0.60
JUN	activates	gene	0.60
ISG15	regulates	gene	0.60
IRF3	regulates	gene	0.60
XRCC6	activates	gene	0.60
ISG15	activates	gene	0.60
PARKIN	regulates	gene	0.60
SNAP23	activates	gene	0.60
ZBP1	activates	gene	0.60
BAX	activates	gene	0.60
IFN	activates	gene	0.60
ISG	degrades	gene	0.60
SAT1	regulates	gene	0.60
IFN	regulates	gene	0.60
RNA	inhibits	gene	0.60
RNA	activates	gene	0.60
MTDNA	regulates	gene	0.60
CMPK2	activates	gene	0.60
RFK	activates	gene	0.60
APOPTOSIS	activates	gene	0.60
CHAC1	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

HERC5

Understanding Entity Pages

Summary

Wiki Pages (9)

herc5

HERC3 — HECT and RLD Domain Containing E3 Ubiquitin Protein Ligase 3

HERC4 (HECT and RLD Domain Containing E3 Ubiquitin Protein Ligase 4)

HERC6 — HECT and RLD Domain Containing E3 Ubiquitin Protein Ligase 6

ISG15 — Interferon-Stimulated Gene 15

XRCC6 Gene

SNAP23 Gene