Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Liver Cancer: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Associated Genes | CANCER, STAT3, NF-ΚB, P53, NRCAM, INFLAMMATION, AKT, PTEN |
| KG Connections | 347 knowledge graph edges |
| Databases | OMIMOrphanetClinicalTrialsPubMed |
Knowledge base pages for this entity
graph TD
Liver_Cancer["<b>Liver Cancer</b>"]
Als{"Als"}
Liver_Cancer -->|"therapeutic_target"| Als
Carcinoma{"Carcinoma"}
Liver_Cancer -->|"associated_with"| Carcinoma
Hepatitis{"Hepatitis"}
Liver_Cancer -->|"associated_with"| Hepatitis
Autophagy["Autophagy"]
Liver_Cancer -->|"therapeutic_target"| Autophagy
Mtor["Mtor"]
Liver_Cancer -.->|"inhibits"| Mtor
CANCER(["CANCER"])
CANCER -->|"associated_with"| Liver_Cancer
Cancer{"Cancer"}
Cancer -->|"associated_with"| Liver_Cancer
style Liver_Cancer fill:#1a3a4a,stroke:#ef5350,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Als | therapeutic_target | disease | 1.00 |
| Carcinoma | associated_with | disease | 1.00 |
| Carcinoma | therapeutic_target | disease | 1.00 |
| Hepatitis | associated_with | disease | 0.85 |
| Infectious Agent Exposure | risk_factor_for | process | 0.85 |
| Autophagy | therapeutic_target | pathway | 0.80 |
| Mtor | inhibits | pathway | 0.80 |
| Ferroptosis | activates | pathway | 0.80 |
| Inflammation | therapeutic_target | disease | 0.75 |
| Hepatitis | therapeutic_target | disease | 0.75 |
| Carcinoma | activates | disease | 0.75 |
| Mtor | therapeutic_target | pathway | 0.70 |
| Mtor | treats | pathway | 0.70 |
| Glycolysis | inhibits | pathway | 0.70 |
| Wnt | therapeutic_target | pathway | 0.70 |
| Nf-Κb | implicated_in | pathway | 0.70 |
| Metastasis | activates | pathway | 0.70 |
| Als | treats | disease | 0.65 |
| Carcinoma | inhibits | disease | 0.65 |
| Als | expressed_in | disease | 0.65 |
| Inflammation | regulates | disease | 0.65 |
| Nafld | associated_with | disease | 0.65 |
| Als | associated_with | disease | 0.65 |
| Tgf-Β | therapeutic_target | pathway | 0.60 |
| Microrna | therapeutic_target | pathway | 0.60 |
| Pi3K/Akt | therapeutic_target | pathway | 0.60 |
| Lipid Metabolism | therapeutic_target | pathway | 0.60 |
| Apoptosis | inhibits | pathway | 0.60 |
| Notch | therapeutic_target | pathway | 0.60 |
| Epigenetic | therapeutic_target | pathway | 0.60 |
| Angiogenesis | regulates | pathway | 0.60 |
| Apoptosis | regulates | pathway | 0.60 |
| Immune Response | regulates | pathway | 0.60 |
| Nf-Κb | therapeutic_target | pathway | 0.60 |
| Er Stress | associated_with | pathway | 0.60 |
| Chaperone | therapeutic_target | pathway | 0.60 |
| Unfolded Protein Response | therapeutic_target | pathway | 0.60 |
| Epigenetic | treats | pathway | 0.60 |
| Lipid Metabolism | treats | pathway | 0.60 |
| Epithelial-Mesenchymal Transition | activates | pathway | 0.60 |
| Drug Resistance | therapeutic_target | pathway | 0.60 |
| Cholesterol | therapeutic_target | pathway | 0.60 |
| Invasion | therapeutic_target | pathway | 0.60 |
| Metastasis | implicated_in | pathway | 0.60 |
| Invasion | expressed_in | pathway | 0.60 |
| Stem Cell | implicated_in | pathway | 0.60 |
| Epithelial-Mesenchymal Transition | expressed_in | pathway | 0.60 |
| Differentiation | regulates | pathway | 0.60 |
| Tgf-Β | regulates | pathway | 0.60 |
| Mapk | therapeutic_target | pathway | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| CANCER | associated_with | gene | 1.00 |
| Cancer | associated_with | disease | 1.00 |
| CANCER | therapeutic_target | gene | 1.00 |
| Cancer | therapeutic_target | disease | 1.00 |
| Tumor | therapeutic_target | disease | 1.00 |
| CANCER | activates | gene | 1.00 |
| Hepatocellular Carcinoma | associated_with | disease | 0.95 |
| Hepatocellular Carcinoma | therapeutic_target | disease | 0.95 |
| CANCER | expressed_in | gene | 0.95 |
| Cancer | activates | disease | 0.95 |
| GENES | therapeutic_target | gene | 0.85 |
| AUTOPHAGY | therapeutic_target | gene | 0.85 |
| INFLAMMATION | therapeutic_target | gene | 0.85 |
| Cancer | expressed_in | disease | 0.85 |
| CANCER | implicated_in | gene | 0.85 |
| GENES | inhibits | gene | 0.85 |
| FERROPTOSIS | activates | gene | 0.85 |
| Mitochondrial Cholesterol Accumulation | contributes_to | process | 0.80 |
| MTOR | therapeutic_target | gene | 0.75 |
| AKT | treats | gene | 0.75 |
| MTOR | treats | gene | 0.75 |
| Infection | associated_with | disease | 0.75 |
| GAIN | expressed_in | gene | 0.75 |
| STAT3 | implicated_in | gene | 0.75 |
| NF-ΚB | implicated_in | gene | 0.75 |
| INFLAMMATION | regulates | gene | 0.75 |
| Cancer | implicated_in | disease | 0.75 |
| CANCER | causes | gene | 0.75 |
| MTOR | inhibits | gene | 0.75 |
| PI3K | activates | gene | 0.75 |
| AKT | activates | gene | 0.75 |
| Tumor | activates | disease | 0.75 |
| Tumor | expressed_in | disease | 0.75 |
| GPX4 | activates | gene | 0.75 |
| AKT | expressed_in | gene | 0.75 |
| Tumor | associated_with | disease | 0.75 |
| DNA | inhibits | gene | 0.75 |
| ERK | inhibits | gene | 0.75 |
| MICRORNAS | therapeutic_target | gene | 0.65 |
| AKT | therapeutic_target | gene | 0.65 |
| PI3K | therapeutic_target | gene | 0.65 |
| FBP1 | regulates | gene | 0.65 |
| CANCER | regulates | gene | 0.65 |
| AUTOPHAGY-RELATED GENES | therapeutic_target | gene | 0.65 |
| LYSOSOME | therapeutic_target | gene | 0.65 |
| ATG7 | therapeutic_target | gene | 0.65 |
| DNA | therapeutic_target | gene | 0.65 |
| ROS | inhibits | gene | 0.65 |
| APOPTOSIS | inhibits | gene | 0.65 |
| UBIQUITIN | therapeutic_target | gene | 0.65 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||