RRM2B

Understanding Entity Pages

This page aggregates everything SciDEX knows about RRM2B: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

RRM2B gene encoding p53-inducible ribonucleotide reductase subunit M2B - critical for mitochondrial DNA maintenance and dNTP synthesis

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graph TD
    RRM2B["RRM2B<br/>(Ribonucleotide Reductase M2 B)"]
    
    %% DNA synthesis pathway
    TK2["TK2<br/>(Thymidine Kinase 2)"]
    DGUOK["DGUOK<br/>(Deoxyguanosine Kinase)"]
    TYMP["TYMP<br/>(Thymidine Phosphorylase)"]
    
    %% Mitochondrial DNA maintenance
    POLG["POLG<br/>(DNA Polymerase Gamma)"]
    POLG2["POLG2<br/>(DNA Polymerase Gamma 2)"]
    TFAM["TFAM<br/>(Transcription Factor A)"]
    TWNK["TWNK<br/>(Twinkle Helicase)"]
    MTDNA["Mitochondrial DNA<br/>Replication"]
    
    %% Mitochondrial function
    OPA1["OPA1<br/>(Optic Atrophy 1)"]
    MFN2["MFN2<br/>(Mitofusin 2)"]
    MPV17["MPV17<br/>(Mitochondrial Protein)"]
    
    %% Disease outcomes
    Als["Amyotrophic Lateral<br/>Sclerosis"]
    Neuropathy["Mitochondrial<br/>Neuropathy"]
    
    %% Central pathways
    RRM2B -->|"provides dNTPs for"| MTDNA
    TK2 -->|"salvage pathway"| MTDNA
    DGUOK -->|"salvage pathway"| MTDNA
    TYMP -->|"regulates nucleotide pool"| MTDNA
    
    POLG -->|"replicates"| MTDNA
    POLG2 -->|"accessory subunit"| POLG
    TFAM -->|"packages and maintains"| MTDNA
    TWNK -->|"unwinds DNA for"| MTDNA
    
    OPA1 -->|"maintains structure"| MTDNA
    MFN2 -->|"fusion affects"| MTDNA
    MPV17 -->|"nucleotide transport"| MTDNA
    
    MTDNA -->|"depletion causes"| Als
    MTDNA -->|"mutations cause"| Neuropathy
    
    %% Styling
    style RRM2B fill:#1a3a4a,stroke:#4fc3f7,color:#e0e0e0
    style MTDNA fill:#1b5e20,stroke:#4caf50,color:#e0e0e0
    style TK2 fill:#4a1a6b,stroke:#9c27b0,color:#e0e0e0
    style DGUOK fill:#4a1a6b,stroke:#9c27b0,color:#e0e0e0
    style POLG fill:#4a1a6b,stroke:#9c27b0,color:#e0e0e0
    style TFAM fill:#4a1a6b,stroke:#9c27b0,color:#e0e0e0
    style Als fill:#7d4200,stroke:#ff9800,color:#e0e0e0
    style Neuropathy fill:#7d4200,stroke:#ff9800,color:#e0e0e0