Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about SUCLA2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Succinate-CoA Ligase ADP Forming Subunit Beta - mitochondrial ATP synthesis enzyme in neurodegeneration
| Gene Symbol | SUCLA2 |
| Full Name | Succinate-CoA Ligase ADP Forming Subunit Beta |
| Aliases | SCS-β, SUCL-BETA, Beta-succinyl CoA synthetase |
| Chromosome | 13q14.2 |
| Protein Type | Enzyme |
| Function | encodes the β subunit of ADP-forming succinyl-CoA synthetase (SCS), also known as succinate-CoA ligase ADP-forming GDP form |
| Primary Expression | tissues with high ATP demand, including brain, heart, and skeletal muscle |
| Molecular Weight | 35 kDa |
| Amino Acids | 30 aa |
| UniProt ID | P53999 |
| NCBI Gene ID | 8802 |
| Ensembl ID | ENSG00000147576 |
| OMIM | 603921 |
| GeneCards | SUCLA2 |
| Human Protein Atlas | SUCLA2 |
| Associated Diseases | neurodegeneration |
| KG Connections | 29 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
SUCLA2["SUCLA2<br/>Succinate-CoA Ligase"]
SUCLG1["SUCLG1<br/>alpha-subunit"]
MTDNA["Mitochondrial DNA"]
TFAM["TFAM<br/>Transcription Factor"]
POLG["POLG<br/>DNA Polymerase gamma"]
OPA1["OPA1<br/>Mitochondrial Dynamics"]
MFN2["MFN2<br/>Mitofusin 2"]
TK2["TK2<br/>Thymidine Kinase"]
RRM2B["RRM2B<br/>Ribonucleotide Reductase"]
DGUOK["DGUOK<br/>Deoxyguanosine Kinase"]
ALS["Amyotrophic Lateral Sclerosis"]
NEUROPATHY["Peripheral Neuropathy"]
ATP_SYNTHESIS["ATP Synthesis"]
MTDNA_DEPLETION["mtDNA Depletion Syndrome"]
MITO_DYSFUNCTION["Mitochondrial Dysfunction"]
SUCLA2 -->|"forms complex with"| SUCLG1
SUCLA2 -->|"catalyzes"| ATP_SYNTHESIS
SUCLA2 -->|"mutations cause"| MTDNA_DEPLETION
TFAM -->|"regulates"| MTDNA
POLG -->|"replicates"| MTDNA
TK2 -->|"provides dNTPs for"| MTDNA
RRM2B -->|"provides dNTPs for"| MTDNA
DGUOK -->|"provides dNTPs for"| MTDNA
MTDNA_DEPLETION -->|"leads to"| MITO_DYSFUNCTION
MITO_DYSFUNCTION -->|"causes"| ALS
MITO_DYSFUNCTION -->|"causes"| NEUROPATHY
OPA1 -->|"maintains"| MITO_DYSFUNCTION
MFN2 -->|"maintains"| MITO_DYSFUNCTION
ATP_SYNTHESIS -->|"impaired in"| MITO_DYSFUNCTION
style SUCLA2 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0
style SUCLG1 fill:#4a1a6b,stroke:#333,stroke-width:2px
style TFAM fill:#4a1a6b,stroke:#333,stroke-width:2px
style POLG fill:#4a1a6b,stroke:#333,stroke-width:2px
style OPA1 fill:#1b5e20,stroke:#333,stroke-width:2px
style MFN2 fill:#1b5e20,stroke:#333,stroke-width:2px
style ALS fill:#7d4200,stroke:#333,stroke-width:2px
style NEUROPATHY fill:#7d4200,stroke:#333,stroke-width:2px
style MTDNA_DEPLETION fill:#ef5350,stroke:#333,stroke-width:2px
style MITO_DYSFUNCTION fill:#ef5350,stroke:#333,stroke-width:2px| Target | Relation | Type | Str |
|---|---|---|---|
| Als | expressed_in | disease | 0.65 |
| Neuropathy | expressed_in | disease | 0.65 |
| SUCLG1 | associated_with | gene | 0.60 |
| TFAM | associated_with | gene | 0.60 |
| POLG | associated_with | gene | 0.60 |
| RNASEH1 | associated_with | gene | 0.60 |
| OPA1 | associated_with | gene | 0.60 |
| TWNK | associated_with | gene | 0.60 |
| MPV17 | associated_with | gene | 0.60 |
| DGUOK | associated_with | gene | 0.60 |
| RRM2B | expressed_in | gene | 0.60 |
| DNA | associated_with | gene | 0.60 |
| MITOCHONDRIAL DNA | associated_with | gene | 0.60 |
| AND | associated_with | gene | 0.60 |
| MTDNA | associated_with | gene | 0.60 |
| MITOCHONDRIA | associated_with | gene | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| POLG2 | associated_with | gene | 0.60 |
| SLC25A4 | associated_with | gene | 0.60 |
| MFN2 | associated_with | gene | 0.60 |
| TYMP | associated_with | gene | 0.60 |
| RRM2B | associated_with | gene | 0.60 |
| TK2 | associated_with | gene | 0.60 |
| DGUOK | associated_with | gene | 0.60 |
| SUCLG1 | expressed_in | gene | 0.60 |
| MPV17 | expressed_in | gene | 0.60 |
| GENES | associated_with | gene | 0.60 |
| MITOCHONDRIAL DNA | expressed_in | gene | 0.60 |
| AND | expressed_in | gene | 0.60 |
| MTDNA | associated_with | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||