Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about SLC25A4: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Gene Symbol | SLC25A4 |
| Full Name | Solute Carrier Family 25 Member 4 (Adenine Nucleotide Translocator 1) |
| Chromosome | 4q31.21 |
| Function | is a mitochondrial carrier protein that catalyzes the exchange of ADP and ATP across the inner mitochondrial membrane. |
| Primary Expression | High expression in heart, skeletal muscle, brain; tissues with high energy demands |
| Molecular Weight | 33 kDa |
| Amino Acids | 298 aa |
| UniProt ID | P12235 |
| NCBI Gene ID | 291 |
| Ensembl ID | ENSG00000151729 |
| OMIM | 103220 |
| GeneCards | SLC25A4 |
| Human Protein Atlas | SLC25A4 |
| KG Connections | 24 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
SLC25A4["SLC25A4 (ANT1)<br/>ADP/ATP Translocase"]
ATP_Transport["ATP/ADP Transport<br/>Across Inner Membrane"]
Mito_Energetics["Mitochondrial<br/>Bioenergetics"]
POLG["POLG<br/>DNA Polymerase gamma"]
TFAM["TFAM<br/>Transcription Factor"]
TWNK["TWNK<br/>Twinkle Helicase"]
mtDNA["Mitochondrial DNA<br/>Maintenance"]
OPA1["OPA1<br/>Fusion Protein"]
MFN2["MFN2<br/>Mitofusin 2"]
Mito_Dynamics["Mitochondrial<br/>Dynamics"]
TK2["TK2<br/>Thymidine Kinase"]
dNTP_Pool["dNTP Pool<br/>Maintenance"]
Mito_Dysfunction["Mitochondrial<br/>Dysfunction"]
Neurodegeneration["Neurodegeneration"]
SLC25A4 -->|"facilitates"| ATP_Transport
ATP_Transport -->|"maintains"| Mito_Energetics
SLC25A4 -->|"interacts with"| POLG
POLG -->|"replicates"| mtDNA
TFAM -->|"regulates"| mtDNA
TWNK -->|"unwinds"| mtDNA
SLC25A4 -->|"coordinates with"| OPA1
OPA1 -->|"promotes"| Mito_Dynamics
MFN2 -->|"mediates"| Mito_Dynamics
TK2 -->|"maintains"| dNTP_Pool
dNTP_Pool -->|"supports"| mtDNA
SLC25A4 -->|"dysfunction leads to"| Mito_Dysfunction
Mito_Dysfunction -->|"causes"| Neurodegeneration
style SLC25A4 fill:#1a3a4a,stroke:#4fc3f7,color:#e0e0e0
style ATP_Transport fill:#1b5e20
style Mito_Energetics fill:#1b5e20
style POLG fill:#4a1a6b
style TFAM fill:#4a1a6b
style OPA1 fill:#4a1a6b
style MFN2 fill:#4a1a6b
style TK2 fill:#4a1a6b
style TWNK fill:#4a1a6b
style Mito_Dysfunction fill:#ef5350
style Neurodegeneration fill:#7d4200| Target | Relation | Type | Str |
|---|---|---|---|
| MFN2 | associated_with | gene | 0.60 |
| TYMP | associated_with | gene | 0.60 |
| RRM2B | associated_with | gene | 0.60 |
| TK2 | associated_with | gene | 0.60 |
| SUCLA2 | associated_with | gene | 0.60 |
| SUCLG1 | associated_with | gene | 0.60 |
| TFAM | associated_with | gene | 0.60 |
| POLG | associated_with | gene | 0.60 |
| RNASEH1 | associated_with | gene | 0.60 |
| OPA1 | associated_with | gene | 0.60 |
| TWNK | associated_with | gene | 0.60 |
| MPV17 | associated_with | gene | 0.60 |
| DGUOK | associated_with | gene | 0.60 |
| GENES | associated_with | gene | 0.60 |
| DNA | associated_with | gene | 0.60 |
| MITOCHONDRIAL DNA | associated_with | gene | 0.60 |
| AND | associated_with | gene | 0.60 |
| MTDNA | associated_with | gene | 0.60 |
| MITOCHONDRIA | associated_with | gene | 0.60 |
| Immune Response | contributes_to | pathway | 0.60 |
| Macrophage | contributes_to | cell_type | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||