SLC25A4

Understanding Entity Pages

This page aggregates everything SciDEX knows about SLC25A4: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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graph TD
    SLC25A4["SLC25A4 (ANT1)
ADP/ATP Translocase"]
    
    ATP_Transport["ATP/ADP Transport
Across Inner Membrane"]
    Mito_Energetics["Mitochondrial
Bioenergetics"]
    
    POLG["POLG
DNA Polymerase gamma"]
    TFAM["TFAM
Transcription Factor"]
    TWNK["TWNK
Twinkle Helicase"]
    mtDNA["Mitochondrial DNA
Maintenance"]
    
    OPA1["OPA1
Fusion Protein"]
    MFN2["MFN2
Mitofusin 2"]
    Mito_Dynamics["Mitochondrial
Dynamics"]
    
    TK2["TK2
Thymidine Kinase"]
    dNTP_Pool["dNTP Pool
Maintenance"]
    
    Mito_Dysfunction["Mitochondrial
Dysfunction"]
    Neurodegeneration["Neurodegeneration"]
    
    SLC25A4 -->|"facilitates"| ATP_Transport
    ATP_Transport -->|"maintains"| Mito_Energetics
    
    SLC25A4 -->|"interacts with"| POLG
    POLG -->|"replicates"| mtDNA
    TFAM -->|"regulates"| mtDNA
    TWNK -->|"unwinds"| mtDNA
    
    SLC25A4 -->|"coordinates with"| OPA1
    OPA1 -->|"promotes"| Mito_Dynamics
    MFN2 -->|"mediates"| Mito_Dynamics
    
    TK2 -->|"maintains"| dNTP_Pool
    dNTP_Pool -->|"supports"| mtDNA
    
    SLC25A4 -->|"dysfunction leads to"| Mito_Dysfunction
    Mito_Dysfunction -->|"causes"| Neurodegeneration
    
    style SLC25A4 fill:#1a3a4a,stroke:#4fc3f7,color:#e0e0e0
    style ATP_Transport fill:#1b5e20
    style Mito_Energetics fill:#1b5e20
    style POLG fill:#4a1a6b
    style TFAM fill:#4a1a6b
    style OPA1 fill:#4a1a6b
    style MFN2 fill:#4a1a6b
    style TK2 fill:#4a1a6b
    style TWNK fill:#4a1a6b
    style Mito_Dysfunction fill:#ef5350
    style Neurodegeneration fill:#7d4200

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