Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about SETD1A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Gene Symbol | SETD1A |
| Full Name | SET Domain Containing 1A, Histone Lysine Methyltransferase |
| Aliases | KMT2F, SET1, SET1A |
| Chromosome | 16p11.2 |
| Protein Type | Transferase |
| Function | encodes a histone H3 lysine 4 (H3K4) methyltransferase that is the catalytic subunit of the SETD1A/COMPASS complex. |
| Gene Type | Protein-coding |
| UniProt ID | O15047 |
| Ensembl ID | ENSG00000099381 |
| OMIM | 611052 |
| GeneCards | SETD1A |
| Human Protein Atlas | SETD1A |
| HGNC | 29010 |
| Entrez Gene | 9739 |
| p.R913 | Nonsense |
| Associated Diseases | schizophrenia |
| Interactions | KMT2B, SHANK3, KMT2D, CACNA1G, KMT2A, ANK3 |
| KG Connections | 30 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
SETD1A["<b>SETD1A</b>"]
Schizophrenia{"Schizophrenia"}
SETD1A -.->|"inhibits"| Schizophrenia
Autism{"Autism"}
SETD1A -.->|"inhibits"| Autism
ANK3(["ANK3"])
SETD1A -.->|"inhibits"| ANK3
GAIN(["GAIN"])
SETD1A -->|"expressed_in"| GAIN
RNA(["RNA"])
SETD1A -->|"expressed_in"| RNA
KMT2B(["KMT2B"])
SETD1A -.->|"inhibits"| KMT2B
KMT2A(["KMT2A"])
KMT2A -.->|"inhibits"| SETD1A
SHANK3(["SHANK3"])
SHANK3 -.->|"inhibits"| SETD1A
GENES(["GENES"])
GENES -.->|"inhibits"| SETD1A
CACNA1G(["CACNA1G"])
CACNA1G -.->|"inhibits"| SETD1A
style SETD1A fill:#1a3a4a,stroke:#ce93d8,stroke-width:3px,color:#ce93d8| Target | Relation | Type | Str |
|---|---|---|---|
| Schizophrenia | inhibits | disease | 0.65 |
| Autism | inhibits | disease | 0.65 |
| GAIN | expressed_in | gene | 0.60 |
| KMT2B | inhibits | gene | 0.60 |
| SHANK3 | inhibits | gene | 0.60 |
| KMT2D | inhibits | gene | 0.60 |
| CACNA1G | inhibits | gene | 0.60 |
| KMT2A | inhibits | gene | 0.60 |
| schizophrenia | regulates | disease | 0.60 |
| schizophrenia | interacts_with | disease | 0.60 |
| schizophrenia | associated_with | disease | 0.60 |
| schizophrenia | implicated_in | disease | 0.60 |
| ANK3 | inhibits | gene | 0.60 |
| RNA | expressed_in | gene | 0.60 |
| AND | inhibits | gene | 0.60 |
| Ras | inhibits | protein | 0.60 |
| epigenetic regulation | participates_in | pathway | 0.60 |
| synaptic plasticity | participates_in | pathway | 0.60 |
| GENE EXPRESSION | inhibits | concept | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||