Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about SH3GL2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
No summary available yet. View on Wiki →
| Name | SH3GL2 |
| Key Genes/Proteins | ENDOPHILINPROTEIN, ROS, FLAVONOIDS, PARKINSON'S DISEASE, PARKINSON, PRKN |
| Related Diseases | Parkinson, Als, Aging, Alzheimer, ALS |
Knowledge base pages for this entity
graph TD
SH3GL2["SH3GL2"]
SH3GL2 -->|"binds"| ENDOPHILINPROTEIN["ENDOPHILINPROTEIN"]
SH3GL2 -->|"target for"| Als["Als"]
SH3GL2 -->|"target for"| Aging["Aging"]
SH3GL2 -->|"expressed in"| Alzheimer["Alzheimer"]
SH3GL2 -->|"expressed in"| ALS["ALS"]
SH3GL2 -->|"target for"| FLAVONOIDS["FLAVONOIDS"]
SH3GL2 -->|"target for"| Oxidative_Stress["Oxidative Stress"]
AGING["AGING"] -->|"target for"| SH3GL2
OXIDATIVE_STRESS["OXIDATIVE STRESS"] -->|"target for"| SH3GL2
LYSOSOME["LYSOSOME"] -->|"target for"| SH3GL2
MITOCHONDRIAL_DYSFUNCTION["MITOCHONDRIAL DYSFUNCTION"] -->|"target for"| SH3GL2
SYNAPSE["SYNAPSE"] -->|"target for"| SH3GL2
ALZHEIMER["ALZHEIMER"] -->|"expressed in"| SH3GL2
GENES["GENES"] -->|"expressed in"| SH3GL2
MEF2C["MEF2C"] -->|"inhibits"| SH3GL2| Target | Relation | Type | Str |
|---|---|---|---|
| ENDOPHILINPROTEIN | binds | protein | 0.80 |
| Parkinson | associated_with | disease | 0.65 |
| Als | therapeutic_target | disease | 0.65 |
| Aging | therapeutic_target | disease | 0.65 |
| Alzheimer | expressed_in | disease | 0.65 |
| Als | expressed_in | disease | 0.65 |
| ALS | expressed_in | disease | 0.65 |
| ROS | associated_with | gene | 0.60 |
| FLAVONOIDS | therapeutic_target | gene | 0.60 |
| PARKINSON'S DISEASE | associated_with | gene | 0.60 |
| PARKINSON | associated_with | gene | 0.60 |
| PRKN | associated_with | gene | 0.60 |
| LRRK2 | associated_with | gene | 0.60 |
| DNA | associated_with | gene | 0.60 |
| SYNJ1 | associated_with | gene | 0.60 |
| Oxidative Stress | therapeutic_target | pathway | 0.60 |
| NRGN | inhibits | gene | 0.60 |
| MEF2C | inhibits | gene | 0.60 |
| AND | inhibits | gene | 0.60 |
| ALZHEIMER'S DISEASE | expressed_in | gene | 0.60 |
| ALZHEIMER | expressed_in | gene | 0.60 |
| SNCA | interacts_with | gene | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| AGING | therapeutic_target | gene | 0.60 |
| OXIDATIVE STRESS | therapeutic_target | gene | 0.60 |
| LYSOSOME | therapeutic_target | gene | 0.60 |
| GENES | associated_with | gene | 0.60 |
| MITOCHONDRIAL DYSFUNCTION | therapeutic_target | gene | 0.60 |
| DNAJC6 | associated_with | gene | 0.60 |
| VPS35 | associated_with | gene | 0.60 |
| SYNAPSE | therapeutic_target | gene | 0.60 |
| ALZHEIMER | expressed_in | gene | 0.60 |
| GENES | expressed_in | gene | 0.60 |
| MEF2C | inhibits | gene | 0.60 |
| NRGN | inhibits | gene | 0.60 |
| LRRK2 | interacts_with | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||