Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about SYNJ1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
SYNJ1 is a gene implicated in neurodegeneration research. Key relationships include: associated with, therapeutic target, implicated in. Associated with Aging, Als, Ms. Connected to 41 entities in the SciDEX knowledge graph.
| Gene Symbol | SYNJ1 |
| Full Name | Synaptojanin 1 |
| Chromosome | 21q22.11 |
| Protein Type | Phosphatase |
| Function | SYNJ1 is crucial for synaptic vesicle cycling |
| Primary Expression | Neuron-enriched |
| Molecular Weight | 165 kDa |
| Amino Acids | 428 aa |
| Exons | 31 |
| Pathways | Endosomal Sorting |
| UniProt ID | SYNJ1 |
| GeneCards | SYNJ1 |
| Human Protein Atlas | SYNJ1 |
| Feature | SYNJ1 |
| Amino acids | 1,428 |
| Associated Diseases | Als, Cancer, Ms, Parkinson |
| Interactions | VPS35, VPS13C, ATP13A2, DNAJC6, FBXO7, PINK1 |
| KG Connections | 79 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
SYNJ1["<b>SYNJ1</b>"]
Parkinson{"Parkinson"}
SYNJ1 -->|"associated with"| Parkinson
Als{"Als"}
SYNJ1 -->|"associated with"| Als
Ms{"Ms"}
SYNJ1 -->|"associated with"| Ms
SYNJ1 -->|"therapeutic target"| Als
Aging{"Aging"}
SYNJ1 -->|"therapeutic target"| Aging
Autophagy(["Autophagy"])
SYNJ1 -->|"associated with"| Autophagy
AUTOPHAGY["AUTOPHAGY"]
SYNJ1 -->|"associated with"| AUTOPHAGY
DNAJC6["DNAJC6"]
SYNJ1 -->|"associated with"| DNAJC6
GENE_MUTATIONS["GENE MUTATIONS"]
SYNJ1 -->|"associated with"| GENE_MUTATIONS
PARK2["PARK2"]
SYNJ1 -->|"associated with"| PARK2
Endocytosis(["Endocytosis"])
SYNJ1 -->|"associated with"| Endocytosis
MITOCHONDRIAL_DYSFUNCTION["MITOCHONDRIAL DYSFUNCTION"]
SYNJ1 -->|"therapeutic target"| MITOCHONDRIAL_DYSFUNCTION
PARKINSON_S_DISEASE["PARKINSON'S DISEASE"]
PARKINSON_S_DISEASE -->|"associated with"| SYNJ1
ALPHA_SYNUCLEIN["ALPHA-SYNUCLEIN"]
ALPHA_SYNUCLEIN -->|"associated with"| SYNJ1
PARKIN["PARKIN"]
PARKIN -->|"associated with"| SYNJ1
LRRK2["LRRK2"]
LRRK2 -->|"associated with"| SYNJ1
INPP5F["INPP5F"]
INPP5F -->|"associated with"| SYNJ1
GAK["GAK"]
GAK -->|"associated with"| SYNJ1
AGING["AGING"]
AGING -->|"therapeutic target"| SYNJ1
FLAVONOIDS["FLAVONOIDS"]
FLAVONOIDS -->|"therapeutic target"| SYNJ1
OXIDATIVE_STRESS["OXIDATIVE STRESS"]
OXIDATIVE_STRESS -->|"therapeutic target"| SYNJ1
LYSOSOME["LYSOSOME"]
LYSOSOME -->|"therapeutic target"| SYNJ1
GENES["GENES"]
GENES -->|"associated with"| SYNJ1
MITOCHONDRIAL_DYSFUNCTION -->|"therapeutic target"| SYNJ1
style SYNJ1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| VPS35 | interacts_with | gene | 0.95 |
| Endosomal Sorting | regulates | process | 0.90 |
| Parkinson's Disease | risk_factor_for | disease | 0.90 |
| Dopamine Release | modulates | process | 0.85 |
| VPS13C | interacts_with | gene | 0.70 |
| Parkinson | associated_with | disease | 0.65 |
| Als | associated_with | disease | 0.65 |
| Ms | associated_with | disease | 0.65 |
| Als | therapeutic_target | disease | 0.65 |
| Aging | therapeutic_target | disease | 0.65 |
| Cancer | associated_with | disease | 0.65 |
| DNAJC6 | associated_with | gene | 0.60 |
| PARK2 | associated_with | gene | 0.60 |
| VPS35 | associated_with | gene | 0.60 |
| PRKN | associated_with | gene | 0.60 |
| VPS13C | expressed_in | gene | 0.60 |
| Autophagy | associated_with | pathway | 0.60 |
| AUTOPHAGY | associated_with | gene | 0.60 |
| GENE MUTATIONS | associated_with | gene | 0.60 |
| Endocytosis | associated_with | pathway | 0.60 |
| MITOCHONDRIAL DYSFUNCTION | therapeutic_target | gene | 0.60 |
| OXIDATIVE STRESS | therapeutic_target | gene | 0.60 |
| Oxidative Stress | therapeutic_target | pathway | 0.60 |
| Mtor | expressed_in | pathway | 0.60 |
| Akt | expressed_in | protein | 0.60 |
| Ras | expressed_in | protein | 0.60 |
| stem cells | expressed_in | cell_type | 0.60 |
| neurons | expressed_in | cell_type | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| ATP13A2 | interacts_with | gene | 0.80 |
| DNAJC6 | interacts_with | gene | 0.80 |
| FBXO7 | interacts_with | gene | 0.80 |
| PINK1 | interacts_with | gene | 0.80 |
| PRKN | interacts_with | gene | 0.80 |
| GBA1 | interacts_with | gene | 0.70 |
| LRRK2 | interacts_with | gene | 0.70 |
| PARK7 | interacts_with | gene | 0.70 |
| SNCA | interacts_with | gene | 0.70 |
| PARKIN | associated_with | gene | 0.60 |
| LRRK2 | associated_with | gene | 0.60 |
| GAK | associated_with | gene | 0.60 |
| DNAJC6 | associated_with | gene | 0.60 |
| VPS35 | associated_with | gene | 0.60 |
| PRKN | associated_with | gene | 0.60 |
| MACF1 | associated_with | gene | 0.60 |
| PHB2 | associated_with | gene | 0.60 |
| PLA2G6 | interacts_with | gene | 0.60 |
| DJ1 | interacts_with | gene | 0.60 |
| ATP13A2 | expressed_in | gene | 0.60 |
| DJ1 | expressed_in | gene | 0.60 |
| DNAJC6 | expressed_in | gene | 0.60 |
| FBXO7 | expressed_in | gene | 0.60 |
| GBA1 | expressed_in | gene | 0.60 |
| LRRK2 | expressed_in | gene | 0.60 |
| PINK1 | expressed_in | gene | 0.60 |
| PRKN | expressed_in | gene | 0.60 |
| SNCA | expressed_in | gene | 0.60 |
| GBA1 | associated_with | gene | 0.60 |
| MAPT | associated_with | gene | 0.60 |
| OPTN | associated_with | gene | 0.60 |
| SQSTM1 | associated_with | gene | 0.60 |
| BIN1 | interacts_with | gene | 0.60 |
| PARKINSON'S DISEASE | associated_with | gene | 0.60 |
| ALPHA-SYNUCLEIN | associated_with | gene | 0.60 |
| INPP5F | associated_with | gene | 0.60 |
| AGING | therapeutic_target | gene | 0.60 |
| FLAVONOIDS | therapeutic_target | gene | 0.60 |
| OXIDATIVE STRESS | therapeutic_target | gene | 0.60 |
| LYSOSOME | therapeutic_target | gene | 0.60 |
| GENES | associated_with | gene | 0.60 |
| MITOCHONDRIAL DYSFUNCTION | therapeutic_target | gene | 0.60 |
| SYNAPSE | therapeutic_target | gene | 0.60 |
| SH3GL2 | associated_with | gene | 0.60 |
| ROS | associated_with | gene | 0.60 |
| PARKINSON | associated_with | gene | 0.60 |
| DNA | associated_with | gene | 0.60 |
| ASTROCYTES | associated_with | gene | 0.60 |
| NEURON | associated_with | gene | 0.60 |
| ASTROCYTE | associated_with | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||