gene

SYNJ1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SYNJ1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

79Connections
0Hypotheses
0Analyses
28Outgoing
50Incoming

Summary

SYNJ1 is a gene implicated in neurodegeneration research. Key relationships include: associated with, therapeutic target, implicated in. Associated with Aging, Als, Ms. Connected to 41 entities in the SciDEX knowledge graph.

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🧬 Gene Info
Gene SymbolSYNJ1
Full NameSynaptojanin 1
Chromosome21q22.11
Protein TypePhosphatase
FunctionSYNJ1 is crucial for synaptic vesicle cycling
Primary ExpressionNeuron-enriched
Molecular Weight165 kDa
Amino Acids428 aa
Exons31
PathwaysEndosomal Sorting
UniProt IDSYNJ1
GeneCardsSYNJ1
Human Protein AtlasSYNJ1
FeatureSYNJ1
Amino acids1,428
Associated DiseasesAls, Cancer, Ms, Parkinson
InteractionsVPS35, VPS13C, ATP13A2, DNAJC6, FBXO7, PINK1
KG Connections79 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

SYNJ1 — Synaptojanin 1

gene · 2470 words

GRIA3 Gene

gene · 5408 words

Synaptic Vesicle Trafficking in Parkinson's Disease

mechanism · 4417 words

Gene-Mechanism-Therapy Causal Chains

mechanism · 4075 words

AP2M1 Gene

gene · 3193 words

FBXO7 Protein (PARK15)

protein · 2779 words

Pathway Diagram

graph TD
    SYNJ1["<b>SYNJ1</b>"]
    Parkinson{"Parkinson"}
    SYNJ1 -->|"associated with"| Parkinson
    Als{"Als"}
    SYNJ1 -->|"associated with"| Als
    Ms{"Ms"}
    SYNJ1 -->|"associated with"| Ms
    SYNJ1 -->|"therapeutic target"| Als
    Aging{"Aging"}
    SYNJ1 -->|"therapeutic target"| Aging
    Autophagy(["Autophagy"])
    SYNJ1 -->|"associated with"| Autophagy
    AUTOPHAGY["AUTOPHAGY"]
    SYNJ1 -->|"associated with"| AUTOPHAGY
    DNAJC6["DNAJC6"]
    SYNJ1 -->|"associated with"| DNAJC6
    GENE_MUTATIONS["GENE MUTATIONS"]
    SYNJ1 -->|"associated with"| GENE_MUTATIONS
    PARK2["PARK2"]
    SYNJ1 -->|"associated with"| PARK2
    Endocytosis(["Endocytosis"])
    SYNJ1 -->|"associated with"| Endocytosis
    MITOCHONDRIAL_DYSFUNCTION["MITOCHONDRIAL DYSFUNCTION"]
    SYNJ1 -->|"therapeutic target"| MITOCHONDRIAL_DYSFUNCTION
    PARKINSON_S_DISEASE["PARKINSON'S DISEASE"]
    PARKINSON_S_DISEASE -->|"associated with"| SYNJ1
    ALPHA_SYNUCLEIN["ALPHA-SYNUCLEIN"]
    ALPHA_SYNUCLEIN -->|"associated with"| SYNJ1
    PARKIN["PARKIN"]
    PARKIN -->|"associated with"| SYNJ1
    LRRK2["LRRK2"]
    LRRK2 -->|"associated with"| SYNJ1
    INPP5F["INPP5F"]
    INPP5F -->|"associated with"| SYNJ1
    GAK["GAK"]
    GAK -->|"associated with"| SYNJ1
    AGING["AGING"]
    AGING -->|"therapeutic target"| SYNJ1
    FLAVONOIDS["FLAVONOIDS"]
    FLAVONOIDS -->|"therapeutic target"| SYNJ1
    OXIDATIVE_STRESS["OXIDATIVE STRESS"]
    OXIDATIVE_STRESS -->|"therapeutic target"| SYNJ1
    LYSOSOME["LYSOSOME"]
    LYSOSOME -->|"therapeutic target"| SYNJ1
    GENES["GENES"]
    GENES -->|"associated with"| SYNJ1
    MITOCHONDRIAL_DYSFUNCTION -->|"therapeutic target"| SYNJ1
    style SYNJ1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (28)

TargetRelationTypeStr
VPS35interacts_withgene0.95
Endosomal Sortingregulatesprocess0.90
Parkinson's Diseaserisk_factor_fordisease0.90
Dopamine Releasemodulatesprocess0.85
VPS13Cinteracts_withgene0.70

Incoming (51)

SourceRelationTypeStr
ATP13A2interacts_withgene0.80
DNAJC6interacts_withgene0.80
FBXO7interacts_withgene0.80
PINK1interacts_withgene0.80
PRKNinteracts_withgene0.80

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found