Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about T3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | T3 |
| Key Genes/Proteins | AKT, BAX, BCL-2, MCT8, MTOR |
| Related Diseases | Alzheimer's disease, brown adipose tissue activation, mitochondrial biogenesis, mitophagy |
| Linked Hypotheses | 19 hypotheses |
Knowledge base pages for this entity
graph TD
T3["T3"]
T3 -->|"activates"| brown_adipose_tissue_activatio["brown adipose tissue activation"]
T3 -->|"inhibits"| BAX["BAX"]
T3 -->|"upregulates"| BCL_2["BCL-2"]
T3 -->|"activates"| mitochondrial_biogenesis["mitochondrial biogenesis"]
T3 -->|"activates"| mitophagy["mitophagy"]
T3 -->|"activates"| AKT["AKT"]
T3 -->|"inhibits"| neuroinflammation["neuroinflammation"]
MCT8["MCT8"] -->|"binds_to"| T3| Target | Relation | Type | Str |
|---|---|---|---|
| BAX | inhibits | protein | 0.95 |
| BCL-2 | upregulates | protein | 0.95 |
| BAX | downregulates | protein | 0.95 |
| brown adipose tissue activation | activates | phenotype | 0.95 |
| mitochondrial biogenesis | activates | phenotype | 0.90 |
| mitophagy | activates | phenotype | 0.90 |
| neuroinflammation | inhibits | process | 0.90 |
| AKT | phosphorylates | protein | 0.90 |
| AKT | activates | protein | 0.90 |
| Alzheimer's disease | treats | disease | 0.85 |
| Alzheimer's disease | protects_against | disease | 0.85 |
| MTOR | inhibits | protein | 0.80 |
Hypotheses where this entity is a therapeutic target
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| iPSC-derived astrocyte-neuron co-culture mitochondrial transfer in PD | exploratory | Parkinson's disease | 0.900 | 0.00 | iPSC-derived dopaminergic neur | proposed | N/A |
| bEV isolation and LPS quantification from human samples | clinical | Alzheimer's disease | 0.800 | 0.00 | human patients | proposed | N/A |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Transcriptomic cytoarchitecture reveals principles of human neocortex organizati [PMID:37824655] | Jorstad NL, Close J, Johansen N, Yanny A | Science | 2023 | 186 |
| Targeted nanovesicular delivery of dexmedetomidine modulates microglial lysosoma [PMID:41778730] | Zhang Y, Jiang H, Zhang F, Liao J | Neural regeneration research | 2026 | 0 |
| The myocardial ischemic cascade network and multi-target synergistic interventio [PMID:41544859] | Qi L, Yi J, Shen Y, Jiang H, Yao X et al | Biochem Pharmacol | 2026 | 0 |
| Homoplantaginin ameliorates osteoarthritis by activating Sirt3/PINK1/Parkin sign [PMID:41720004] | Zhang H, Xiao J, Yi Y, Chen B, Lv W et a | Phytomedicine | 2026 | 0 |
| Kakkalide promotes spinal cord injury repair by regulating microglial M2 polariz [PMID:41720005] | You T, Dai B, Ding X, He Z, Peng J et al | Phytomedicine | 2026 | 0 |
| Interaction of mtROS-Immune-Inflammatory Vicious Cycle Activation in Sepsis-Indu [PMID:41905969] | Wang Y, Yuan Q | Clin Exp Pharmacol Physiol | 2026 | 0 |
| Metformin attenuates HSV-1-induced neuropathic pain by restoring Sirt3-mediated [PMID:41896899] | Yuanyuan Fang; Mengqiu Deng; Kesheng Hua | Cell communication and signali | 2026 | 0 |
| Hydrogen-Enriched Hyaluronic Acid Dressing Ameliorates Diabetic Foot Ulcer via P [PMID:41906653] | Xu Z, Cui X, Chu H, Wan H, Xie Y, Wang Y | Journal of diabetes | 2026 | 0 |
| Inhibition of mitochondrial ROS turns LC3-associated phagocytosis to autophagy u [PMID:41896101] | Cheng YL, Su MS, Liao CC, Chang TW, Hsie | Journal of microbiology, immun | 2026 | 0 |
| Hyperoside stabilizes ACAT1 to promote fatty acid oxidation and attenuate kidney [PMID:41903436] | Shan C, Szili-Torok T, Yue G, Zhang L, M | Phytomedicine : international | 2026 | 0 |
| Melatonin Ameliorates decaBDE-Induced Autism-Relevant Behaviors Through Promotin [PMID:41897550] | ["Gao L", "Shen J", "Gao J", "Li T", "Ya | Antioxidants (Basel, Switzerla | 2026 | 0 |
| Sirtuins as mediators and targets of arsenic toxicity: unraveling signaling path [PMID:40844627] | El-Mahrouk SR, El-Kadi AOS | Archives of toxicology | 2025 | 0 |
| Targeted activation of ErbB4 receptor ameliorates neuronal deficits and neuroinf [PMID:40089796] | Liu C, Zhao Y, Zhang W, Dao JJ, Li Q, Hu | Journal of neuroinflammation | 2025 | 0 |
| Phenylpropanoids of Eleutherococcus senticosus (Rupr. & maxim.) maxim. Alleviate [PMID:40081261] | Yang R, Meng X, Zhao W, Xu SQ, Wang SY, | Bioorganic chemistry | 2025 | 0 |
| Small molecule DDQ involvement of ERK-mediated signaling pathway with enhanced m [PMID:40222458] | Pradeepkiran JA, Kshirsagar S, Alvir RV, | Biochimica et biophysica acta. | 2025 | 0 |
| The effects of Honokiol on the liver of Alzheimer's disease mice by upregulating [PMID:40776632] | Wang H, Liu J, Tian YR, Zhu F, Li H | Journal of Alzheimer's disease | 2025 | 0 |
| P-tau217 correlates with neurodegeneration in Alzheimer's disease, and targeting [PMID:38513667] | Zhang D, Zhang W, Ming C, Gao X, Yuan H, | Neuron | 2024 | 0 |
| Icariin, astragaloside a and puerarin mixture attenuates cognitive impairment in [PMID:38412923] | ["Zhang Tian-Ci", "Lin Yi-Can", "Sun Nin | Neurochemistry international | 2024 | 0 |
| The necroptosis cell death pathway drives neurodegeneration in Alzheimer's disea [PMID:38852117] | Balusu S, De Strooper B | Acta neuropathologica | 2024 | 0 |
| Inflammatory Processes in Alzheimer's Disease-Pathomechanism, Diagnosis and Trea [PMID:37047492] | Unknown | Int J Mol Sci | 2023 | 0 |
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning T3 in their description or question text
Score: 0.624 · neurodegeneration · 2026-04-25
Integrated stress response factors redirect transcription and chromatin regulation away from tau expression during acute
Score: 0.618 · neurodegeneration · 2026-04-22
**Molecular Mechanism and Rationale** The proposed PDGF-BB/PDGFRβ/STAT3 signaling axis represents a complex intercellul
Score: 0.560 · neurodegeneration · 2026-04-25
Declining SIRT3 activity leaves SOD2, IDH2, and permeability-transition regulators hyperacetylated, reducing mitochondri
Score: 0.551 · neuroinflammation · 2026-04-20
## Mechanistic Overview Astrocytic SPP1 Modulation Through STAT3-Dependent Transcriptional Control starts from the claim
Score: 0.547 · neuroinflammation · 2026-04-26
Astrocyte-derived CNTF binds CNTFRα-GP130-LIFRβ receptor complex on microglia, activating JAK1/2 → STAT3 phosphorylation
Score: 0.540 · neuroinflammation · 2026-04-21
## Mechanistic Overview Systemic IL-6–STAT3–Hepatic C3 Axis and BBB-Mediated Complement Translocation starts from the cl
Score: 0.482 · neuroinflammation · 2026-04-21
## Mechanistic Overview SIRT3 gates microglial surveillance versus primed metabolism through mitochondrial deacetylation
Score: 0.460 · neurodegeneration · 2026-04-21
## Mechanistic Overview DNMT3A-Mediated de novo Methylation Corrects 'Epigenetic Scars' at Polycomb Targets starts from
Score: 0.459 · neuroinflammation · 2026-04-21
## Mechanistic Overview Astrocytic SPP1 Modulation via STAT3-Dependent Transcriptional Control starts from the claim tha
Score: 0.454 · lipidomics · 2026-04-25
GM1 Ganglioside Reduction via ST3GAL5 Activation to Block Aβ Oligomerization Seeds
Score: 0.442 · neurodegeneration · 2026-04-22
## Mechanistic Overview RAGE/STAT3/IL-6 Autocrine Loop Mediates Aβ-Induced SPP1 Upregulation in Perivascular Fibroblasts
Score: 0.347 · immunomics · 2026-04-25
STAT3 Epigenetic Priming as Mechanism of Peripheral Cytokine Memory
Score: 0.344 · connectomics · 2026-04-25
SIRT3 Mitochondrial Activation to Counter Hub-Specific Energetic Vulnerability
Score: 0.000 · unknown disease · 2026-04-28
Selective enhancement of ST3GAL5 (GM3 synthase) activity to restore optimal GM1/GM3 ratios and prevent amyloid nucleatio