concept

MCT8

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MCT8: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

104Connections

0Hypotheses

0Analyses

50Outgoing

14Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	MCT8
Related Diseases	Allan-Herndon-Dudley Syndrome, Cerebral Hypothyroidism, cerebral hypothyroidism, Allan-Herndon-Dudley syndrome
Related Pathways	Thyroid Hormone Metabolism, X-Linked Inheritance

Wiki Pages (11)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    MCT8["MCT8"]
    MCT8 -->|"involved_in"| Thyroid_Hormone_Metabolism["Thyroid Hormone Metabolism"]
    MCT8 -->|"transports"| Thyroid_Hormone["Thyroid Hormone"]
    MCT8 -->|"causes"| Allan_Herndon_Dudley_Syndrome["Allan-Herndon-Dudley Syndrome"]
    MCT8 -->|"regulates"| ASTROCYTE["ASTROCYTE"]
    MCT8 -->|"target for"| Cancer["Cancer"]
    MCT8 -->|"target for"| Aging["Aging"]
    MCT8 -->|"causes"| Als["Als"]
    SLC16A2["SLC16A2"] -->|"encodes"| MCT8
    AGING["AGING"] -->|"target for"| MCT8
    NEURON["NEURON"] -->|"inhibits"| MCT8
    SLC16A10["SLC16A10"] -->|"transports"| MCT8
    SLC16A3["SLC16A3"] -->|"target for"| MCT8

Outgoing (90)

Target	Relation	Type	Str
Thyroid Hormone Metabolism	involved_in	pathway	1.00
ALLAN-HERNDON-DUDLEY SYNDROME	associated_with	entity	0.98
THYROID HORMONE	associated_with	entity	0.95
Thyroid Hormone	transports	compound	0.95
Allan-Herndon-Dudley Syndrome	causes	disease	0.95
Thyroid Hormone Transport	mediates	process	0.95
NEURODEGENERATION	associated_with	entity	0.90
Cerebral Hypothyroidism	associated_with	phenotype	0.90
cerebral hypothyroidism	causes	phenotype	0.90
Thyroid Hormones	transports	molecule	0.90
ASTROCYTE	regulates	entity	0.85
X-Linked Inheritance	associated_with	mechanism	0.85
Brain	expressed_in	brain_region	0.85
Allan-Herndon-Dudley syndrome	therapeutic_target	disease	0.80
SLC16A2	translocates_to	gene	0.70
oxidative stress response	participates_in	pathway	0.70
neurodegeneration	causes	disease	0.70
neurons	expressed_in	cell_type	0.70
Cancer	therapeutic_target	disease	0.65
Aging	therapeutic_target	disease	0.65
Als	causes	disease	0.65
Neurodegeneration	associated_with	disease	0.65
Als	associated_with	disease	0.65
Aging	causes	disease	0.65
Als	transports	disease	0.65
Anxiety	transports	disease	0.65
Neurodegeneration	transports	disease	0.65
thyroid hormone	binds_to	drug	0.60
T3	binds_to	drug	0.60
T4	binds_to	drug	0.60
T3	interacts_with	drug	0.60
thyroid hormone resistance	contributes_to	disease	0.60
blood-brain barrier	interacts_with	cell_type	0.60
hippocampal neurogenesis	involved_in	pathway	0.60
BASIGIN	interacts_with	protein	0.60
SLC16A1	associated_with	gene	0.60
SLC16A3	therapeutic_target	gene	0.60
ASTROCYTES	therapeutic_target	gene	0.60
RNA	causes	gene	0.60
Astrocyte	therapeutic_target	cell_type	0.60
Blood-Brain Barrier	regulates	pathway	0.60
T Cell	therapeutic_target	cell_type	0.60
Neuron	expressed_in	cell_type	0.60
Blood-Brain Barrier	causes	pathway	0.60
T Cell	causes	cell_type	0.60
Fibroblast	regulates	cell_type	0.60
Neurogenesis	associated_with	pathway	0.60
Neuron	inhibits	cell_type	0.60
Neurogenesis	activates	pathway	0.60
Neuron	associated_with	cell_type	0.60

Incoming (14)

Source	Relation	Type	Str
Thyroid Hormone	interacts_with	compound	0.90
SLC16A2	encodes	gene	0.60
SLC16A10	associated_with	gene	0.60
SLC16A2	associated_with	gene	0.60
AGING	therapeutic_target	gene	0.60
SLC16A2	causes	gene	0.60
SLC16A2	regulates	gene	0.60
NEURON	inhibits	gene	0.60
SLC16A10	transports	gene	0.60
SLC16A3	therapeutic_target	gene	0.60
SLC16A2	transports	gene	0.60
ASTROCYTES	therapeutic_target	gene	0.60
RNA	causes	gene	0.60
SLC16A1	transports	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

MCT8

Understanding Entity Pages

Wiki Pages (11)

Thyroid Hormone Signaling Pathway in Neurodegeneration

SLC16A2 Gene (MCT8)

Intellectual Disability

Medial Eminence

Hypothalamic Tanycytes

Allan-Herndon-Dudley Syndrome

Medial Nucleus of the Trapezoid Body (MNTB) Neurons

Median Eminence Beta Tanycytes

Median Eminence