Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about T3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | T3 |
| Key Genes/Proteins | BAX, BCL-2, AKT, MTOR, MCT8 |
| Related Diseases | brown adipose tissue activation, mitochondrial biogenesis, mitophagy, Alzheimer's disease |
| Linked Hypotheses | 4 hypotheses |
Knowledge base pages for this entity
graph TD
T3["T3"]
T3 -->|"activates"| brown_adipose_tissue_activatio["brown adipose tissue activation"]
T3 -->|"inhibits"| BAX["BAX"]
T3 -->|"upregulates"| BCL_2["BCL-2"]
T3 -->|"activates"| mitochondrial_biogenesis["mitochondrial biogenesis"]
T3 -->|"activates"| mitophagy["mitophagy"]
T3 -->|"activates"| AKT["AKT"]
T3 -->|"inhibits"| neuroinflammation["neuroinflammation"]
MCT8["MCT8"] -->|"binds_to"| T3| Target | Relation | Type | Str |
|---|---|---|---|
| brown adipose tissue activation | activates | phenotype | 0.95 |
| BAX | inhibits | protein | 0.95 |
| BCL-2 | upregulates | protein | 0.95 |
| BAX | downregulates | protein | 0.95 |
| mitochondrial biogenesis | activates | phenotype | 0.90 |
| mitophagy | activates | phenotype | 0.90 |
| AKT | activates | protein | 0.90 |
| neuroinflammation | inhibits | process | 0.90 |
| AKT | phosphorylates | protein | 0.90 |
| Alzheimer's disease | protects_against | disease | 0.85 |
| Alzheimer's disease | treats | disease | 0.85 |
| MTOR | inhibits | protein | 0.80 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| SIRT3-Mediated Mitochondrial Deacetylation Failure with PINK | 0.509 | Alzheimer's Disease | Cell type vulnerability in Alzheimers Di |
| LPCAT3-Mediated Lands Cycle Remodeling as the Primary Ferrop | 0.493 | Alzheimer's Disease | Cell type vulnerability in Alzheimers Di |
| LPCAT3-Mediated Lands Cycle Amplification of Ferroptotic Sub | 0.491 | Alzheimer's Disease | Cell type vulnerability in Alzheimers Di |
| LPCAT3-Mediated Lands Cycle Amplification of Ferroptotic Vul | 0.485 | Alzheimer's Disease | Cell type vulnerability in Alzheimers Di |
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Targeted nanovesicular delivery of dexmedetomidine modulates microglial lysosoma [PMID:41778730] | Zhang Y, Jiang H, Zhang F, Liao J | Neural regeneration research | 2026 | 0 |
| The myocardial ischemic cascade network and multi-target synergistic interventio [PMID:41544859] | Qi L, Yi J, Shen Y, Jiang H, Yao X et al | Biochem Pharmacol | 2026 | 0 |
| Homoplantaginin ameliorates osteoarthritis by activating Sirt3/PINK1/Parkin sign [PMID:41720004] | Zhang H, Xiao J, Yi Y, Chen B, Lv W et a | Phytomedicine | 2026 | 0 |
| Kakkalide promotes spinal cord injury repair by regulating microglial M2 polariz [PMID:41720005] | You T, Dai B, Ding X, He Z, Peng J et al | Phytomedicine | 2026 | 0 |
| AARS2 R199C mutation induces lactylation-driven premature ovarian insufficiency [PMID:41832996] | Zhang HH, Zhang ZL, Xu W | Reproduction | 2026 | 0 |
| Interaction of mtROS-Immune-Inflammatory Vicious Cycle Activation in Sepsis-Indu [PMID:41905969] | Wang Y, Yuan Q | Clin Exp Pharmacol Physiol | 2026 | 0 |
| FGFR1 suppresses ovarian cancer progression by modulating SIRT3-dependent lactyl [PMID:41946672] | Jiang F, Huang H, Dong Z, Zhang L, Zhang | Cell Death Discov | 2026 | 0 |
| Adipocyte small extracellular vesicle-derived microRNA-30a-3p exacerbates hepati [PMID:41965824] | Zhang T, Hu L, Chen D, Chen Y, Zhou F et | Nat Commun | 2026 | 0 |
| α7-nAChR activation mitigates pyridaben-induced hepatotoxicity in grass carp (Ct [PMID:41966317] | Wu C, Jiang J, Qiu H, Xie J, Li S | Fish Shellfish Immunol | 2026 | 0 |
| Metformin attenuates HSV-1-induced neuropathic pain by restoring Sirt3-mediated [PMID:41896899] | Fang Y, Deng M, Huang K, Song H, Chu Y, | Cell communication and signali | 2026 | 0 |
| Hydrogen-Enriched Hyaluronic Acid Dressing Ameliorates Diabetic Foot Ulcer via P [PMID:41906653] | Xu Z, Cui X, Chu H, Wan H, Xie Y, Wang Y | Journal of diabetes | 2026 | 0 |
| Inhibition of mitochondrial ROS turns LC3-associated phagocytosis to autophagy u [PMID:41896101] | Cheng YL, Su MS, Liao CC, Chang TW, Hsie | Journal of microbiology, immun | 2026 | 0 |
| Hyperoside stabilizes ACAT1 to promote fatty acid oxidation and attenuate kidney [PMID:41903436] | Shan C, Szili-Torok T, Yue G, Zhang L, M | Phytomedicine : international | 2026 | 0 |
| Melatonin Ameliorates decaBDE-Induced Autism-Relevant Behaviors Through Promotin [PMID:41897550] | ["Gao L", "Shen J", "Gao J", "Li T", "Ya | Antioxidants (Basel, Switzerla | 2026 | 0 |
| LPCAT3 deficiency Drives phospholipid remodeling and mitochondrial oxidative dys [PMID:41951050] | Shao G, Ye C, Sun C, Pan J, Lu L et al. | J Adv Res | 2026 | 0 |
| Sirtuins as mediators and targets of arsenic toxicity: unraveling signaling path [PMID:40844627] | El-Mahrouk SR, El-Kadi AOS | Archives of toxicology | 2025 | 0 |
| Targeted activation of ErbB4 receptor ameliorates neuronal deficits and neuroinf [PMID:40089796] | Liu C, Zhao Y, Zhang W, Dao JJ, Li Q, Hu | Journal of neuroinflammation | 2025 | 0 |
| Phenylpropanoids of Eleutherococcus senticosus (Rupr. & maxim.) maxim. Alleviate [PMID:40081261] | Yang R, Meng X, Zhao W, Xu SQ, Wang SY, | Bioorganic chemistry | 2025 | 0 |
| Small molecule DDQ involvement of ERK-mediated signaling pathway with enhanced m [PMID:40222458] | Pradeepkiran JA, Kshirsagar S, Alvir RV, | Biochimica et biophysica acta. | 2025 | 0 |
| The effects of Honokiol on the liver of Alzheimer's disease mice by upregulating [PMID:40776632] | Wang H, Liu J, Tian YR, Zhu F, Li H | Journal of Alzheimer's disease | 2025 | 0 |