protein

TGFB3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TGFB3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

22Connections
0Hypotheses
0Analyses
9Outgoing
13Incoming

Summary

TGFB3 is a protein involved in neurodegeneration research. Key relationships include: associated with, implicated in. Associated with Migraine. Connected to 13 entities in the SciDEX knowledge graph.

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🔬 Protein Info
Gene SymbolTGFB3
Full NameTransforming Growth Factor Beta 3
Chromosome14q13.3
Functionis an important component in the neurobiology of neurodegenerative diseases.
PathwaysTGF-β, TGF-β signaling
UniProt IDP10615
NCBI Gene ID7049
Ensembl IDENSG00000119699
OMIM190230
GeneCardsTGFB3
Human Protein AtlasTGFB3
Associated DiseasesMigraine
KG Connections22 knowledge graph edges
DatabasesGeneCardsHPASTRING
🔮 Predicted Structure: TGFB3 — AlphaFold P10615 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (11)

Knowledge base pages for this entity

Canonical Page

TGFB3 Gene

gene · 853 words

TGF-β1 Protein

protein · 1635 words

TGF-beta Signaling Pathway in Neurodegeneration

mechanism · 1480 words

TGFBI

gene · 1427 words

TGF-beta Signaling Therapeutics for Neurodegeneration: Investment Analysis

investment · 1328 words

TGFB2 Protein

protein · 883 words

Pathway Diagram

graph TD
    TGFB3["<b>TGFB3</b>"]
    Migraine{"Migraine"}
    TGFB3 -->|"associated with"| Migraine
    neurodegeneration["neurodegeneration"]
    TGFB3 -->|"implicated in"| neurodegeneration
    KCNK5["KCNK5"]
    KCNK5 -->|"associated with"| TGFB3
    TGFB1["TGFB1"]
    TGFB1 -->|"associated with"| TGFB3
    TP53["TP53"]
    TP53 -->|"associated with"| TGFB3
    NR1D1["NR1D1"]
    NR1D1 -->|"associated with"| TGFB3
    FXN["FXN"]
    FXN -->|"associated with"| TGFB3
    EPHA5["EPHA5"]
    EPHA5 -->|"associated with"| TGFB3
    EP300["EP300"]
    EP300 -->|"associated with"| TGFB3
    NLGN2["NLGN2"]
    NLGN2 -->|"associated with"| TGFB3
    CDK4["CDK4"]
    CDK4 -->|"associated with"| TGFB3
    CHD4["CHD4"]
    CHD4 -->|"associated with"| TGFB3
    HMGCR["HMGCR"]
    HMGCR -->|"associated with"| TGFB3
    style TGFB3 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (9)

TargetRelationTypeStr
Migraineassociated_withdisease0.65
TGFB1expressed_ingene0.60
TGFB2expressed_ingene0.60
VEGFBexpressed_ingene0.60
CSF2expressed_ingene0.60

Incoming (13)

SourceRelationTypeStr
KCNK5associated_withgene0.60
TGFB1associated_withgene0.60
TP53associated_withgene0.60
NR1D1associated_withgene0.60
FXNassociated_withgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found