Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about TGFB3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
TGFB3 is a protein involved in neurodegeneration research. Key relationships include: associated with, implicated in. Associated with Migraine. Connected to 13 entities in the SciDEX knowledge graph.
| Gene Symbol | TGFB3 |
| Full Name | Transforming Growth Factor Beta 3 |
| Chromosome | 14q13.3 |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Pathways | TGF-β, TGF-β signaling |
| UniProt ID | P10615 |
| NCBI Gene ID | 7049 |
| Ensembl ID | ENSG00000119699 |
| OMIM | 190230 |
| GeneCards | TGFB3 |
| Human Protein Atlas | TGFB3 |
| Associated Diseases | Migraine |
| KG Connections | 22 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
TGFB3["<b>TGFB3</b>"]
Migraine{"Migraine"}
TGFB3 -->|"associated with"| Migraine
neurodegeneration["neurodegeneration"]
TGFB3 -->|"implicated in"| neurodegeneration
KCNK5["KCNK5"]
KCNK5 -->|"associated with"| TGFB3
TGFB1["TGFB1"]
TGFB1 -->|"associated with"| TGFB3
TP53["TP53"]
TP53 -->|"associated with"| TGFB3
NR1D1["NR1D1"]
NR1D1 -->|"associated with"| TGFB3
FXN["FXN"]
FXN -->|"associated with"| TGFB3
EPHA5["EPHA5"]
EPHA5 -->|"associated with"| TGFB3
EP300["EP300"]
EP300 -->|"associated with"| TGFB3
NLGN2["NLGN2"]
NLGN2 -->|"associated with"| TGFB3
CDK4["CDK4"]
CDK4 -->|"associated with"| TGFB3
CHD4["CHD4"]
CHD4 -->|"associated with"| TGFB3
HMGCR["HMGCR"]
HMGCR -->|"associated with"| TGFB3
style TGFB3 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Source | Relation | Type | Str |
|---|---|---|---|
| KCNK5 | associated_with | gene | 0.60 |
| TGFB1 | associated_with | gene | 0.60 |
| TP53 | associated_with | gene | 0.60 |
| NR1D1 | associated_with | gene | 0.60 |
| FXN | associated_with | gene | 0.60 |
| EPHA5 | associated_with | gene | 0.60 |
| EP300 | associated_with | gene | 0.60 |
| NLGN2 | associated_with | gene | 0.60 |
| CDK4 | associated_with | gene | 0.60 |
| CHD4 | associated_with | gene | 0.60 |
| HMGCR | associated_with | gene | 0.60 |
| VEGFA | expressed_in | gene | 0.60 |
| PDGFB | expressed_in | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||