Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about VEGFB: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
VEGFB is a protein involved in neurodegeneration research. Key relationships include: activates, regulates, expressed in. Associated with ALS, Als, Arthritis. Connected to 34 entities in the SciDEX knowledge graph.
| Gene Symbol | VEGFB |
| Full Name | Vascular Endothelial Growth Factor B |
| Chromosome | 11q13.1 |
| Function | VEGFB is a member of the VEGF family: |
| Molecular Weight | 22 kDa |
| Pathways | Akt, Angiogenesis, Pi3K, Pi3K/Akt, blood-brain barrier |
| UniProt ID | [P49763](https://www.uniprot.org/uniprot/P49763) |
| Ensembl ID | ENSG00000173511 |
| GeneCards | VEGFB |
| Human Protein Atlas | VEGFB |
| Associated Diseases | ALS, Alzheimer, disease |
| Interactions | VEGF, FGF2, PDGFRB, ANGPT1, BMP2, PI3K |
| KG Connections | 114 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
VEGFB["<b>VEGFB</b>"]
Als{"Als"}
VEGFB -->|"activates"| Als
Metabolic_Syndrome{"Metabolic Syndrome"}
VEGFB -->|"regulates"| Metabolic_Syndrome
Arthritis{"Arthritis"}
VEGFB -->|"activates"| Arthritis
ALS{"ALS"}
VEGFB -->|"activates"| ALS
Angiogenesis(["Angiogenesis"])
VEGFB -->|"activates"| Angiogenesis
VEGF["VEGF"]
VEGFB -->|"activates"| VEGF
FGF2["FGF2"]
VEGFB -->|"activates"| FGF2
RUNX2["RUNX2"]
VEGFB -->|"activates"| RUNX2
PDGFRB["PDGFRB"]
VEGFB -->|"activates"| PDGFRB
GENES["GENES"]
VEGFB -->|"activates"| GENES
ANGPT1["ANGPT1"]
VEGFB -->|"activates"| ANGPT1
BMP2["BMP2"]
VEGFB -->|"activates"| BMP2
BMP2 -->|"activates"| VEGFB
VEGF -->|"activates"| VEGFB
FGF2 -->|"activates"| VEGFB
ANGPT1 -->|"activates"| VEGFB
PDGFRB -->|"activates"| VEGFB
PI3K["PI3K"]
PI3K -->|"activates"| VEGFB
AKT["AKT"]
AKT -->|"activates"| VEGFB
RUNX2 -->|"activates"| VEGFB
GENES -->|"activates"| VEGFB
AND["AND"]
AND -->|"activates"| VEGFB
style VEGFB fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Als | activates | disease | 0.75 |
| Arthritis | activates | disease | 0.65 |
| Metabolic Syndrome | regulates | disease | 0.65 |
| ALS | activates | disease | 0.65 |
| Nafld | activates | disease | 0.65 |
| Fatty Liver | activates | disease | 0.65 |
| Insulin Resistance | regulates | disease | 0.65 |
| Alzheimer | associated_with | disease | 0.65 |
| Als | associated_with | disease | 0.65 |
| ALS | associated_with | disease | 0.65 |
| VEGF | activates | gene | 0.60 |
| FGF2 | activates | gene | 0.60 |
| PDGFRB | activates | gene | 0.60 |
| ANGPT1 | activates | gene | 0.60 |
| BMP2 | activates | gene | 0.60 |
| PI3K | activates | gene | 0.60 |
| AKT | activates | gene | 0.60 |
| APOE | associated_with | gene | 0.60 |
| BIN1 | associated_with | gene | 0.60 |
| SMPD1 | associated_with | gene | 0.60 |
| CFB | associated_with | gene | 0.60 |
| Osteoblast | activates | cell_type | 0.60 |
| CLU | associated_with | gene | 0.60 |
| VEGFA | contributes_to | gene | 0.60 |
| CTSF | associated_with | gene | 0.60 |
| Rb | activates | protein | 0.60 |
| Vegf | contributes_to | protein | 0.60 |
| CSF2 | expressed_in | gene | 0.60 |
| Vegf | expressed_in | protein | 0.60 |
| Rb | expressed_in | protein | 0.60 |
| Angiogenesis | activates | pathway | 0.60 |
| RUNX2 | activates | gene | 0.60 |
| GENES | activates | gene | 0.60 |
| IRS1 | activates | gene | 0.60 |
| Akt | activates | pathway | 0.60 |
| Pi3K | activates | pathway | 0.60 |
| INSULIN RESISTANCE | regulates | gene | 0.60 |
| Pi3K/Akt | activates | pathway | 0.60 |
| Endothelial | activates | cell_type | 0.60 |
| Stem Cell | activates | cell_type | 0.60 |
| Immune Response | associated_with | pathway | 0.60 |
| Endothelial | contributes_to | cell_type | 0.60 |
| Myelination | associated_with | pathway | 0.60 |
| AND | activates | gene | 0.60 |
| ALZHEIMER | associated_with | gene | 0.60 |
| SMOC2 | contributes_to | gene | 0.60 |
| ACHE | contributes_to | gene | 0.60 |
| Pdgf | activates | protein | 0.60 |
| Fgf | activates | protein | 0.60 |
| Ras | activates | protein | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| BMP2 | activates | gene | 0.60 |
| VEGF | activates | gene | 0.60 |
| FGF2 | activates | gene | 0.60 |
| ANGPT1 | activates | gene | 0.60 |
| PDGFRB | activates | gene | 0.60 |
| PI3K | activates | gene | 0.60 |
| AKT | activates | gene | 0.60 |
| ANGPT1 | expressed_in | entity | 0.60 |
| FGF2 | expressed_in | entity | 0.60 |
| PDGFRB | expressed_in | entity | 0.60 |
| VEGFA | contributes_to | gene | 0.60 |
| CLU | associated_with | gene | 0.60 |
| CTSF | associated_with | gene | 0.60 |
| CFB | associated_with | gene | 0.60 |
| SMPD1 | associated_with | gene | 0.60 |
| APOE | associated_with | gene | 0.60 |
| BIN1 | associated_with | gene | 0.60 |
| VEGFA | expressed_in | gene | 0.60 |
| PDGFB | expressed_in | gene | 0.60 |
| TGFB3 | expressed_in | gene | 0.60 |
| TGFB1 | expressed_in | gene | 0.60 |
| TGFB2 | expressed_in | gene | 0.60 |
| VEGFA | implicated_in | gene | 0.60 |
| C1R | interacts_with | gene | 0.60 |
| C1S | interacts_with | gene | 0.60 |
| CLN5 | interacts_with | gene | 0.60 |
| CR1 | interacts_with | gene | 0.60 |
| PARP1 | interacts_with | gene | 0.60 |
| SIGLEC9 | interacts_with | gene | 0.60 |
| SIRPA | interacts_with | gene | 0.60 |
| TPP1 | interacts_with | gene | 0.60 |
| RUNX2 | activates | gene | 0.60 |
| GENES | activates | gene | 0.60 |
| AND | activates | gene | 0.60 |
| ACHE | contributes_to | gene | 0.60 |
| ALZHEIMER | associated_with | gene | 0.60 |
| ALZHEIMER DISEASE | associated_with | gene | 0.60 |
| SMOC2 | contributes_to | gene | 0.60 |
| AND | contributes_to | gene | 0.60 |
| ALZHEIMER'S DISEASE | associated_with | gene | 0.60 |
| ACHE | implicated_in | gene | 0.60 |
| SMOC2 | implicated_in | gene | 0.60 |
| SPARC | associated_with | protein | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||