protein

VEGFB

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about VEGFB: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

114Connections
0Hypotheses
0Analyses
50Outgoing
43Incoming

Summary

VEGFB is a protein involved in neurodegeneration research. Key relationships include: activates, regulates, expressed in. Associated with ALS, Als, Arthritis. Connected to 34 entities in the SciDEX knowledge graph.

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🔬 Protein Info
Gene SymbolVEGFB
Full NameVascular Endothelial Growth Factor B
Chromosome11q13.1
FunctionVEGFB is a member of the VEGF family:
Molecular Weight22 kDa
PathwaysAkt, Angiogenesis, Pi3K, Pi3K/Akt, blood-brain barrier
UniProt ID[P49763](https://www.uniprot.org/uniprot/P49763)
Ensembl IDENSG00000173511
GeneCardsVEGFB
Human Protein AtlasVEGFB
Associated DiseasesALS, Alzheimer, disease
InteractionsVEGF, FGF2, PDGFRB, ANGPT1, BMP2, PI3K
KG Connections114 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Wiki Pages (15)

Knowledge base pages for this entity

Canonical Page

VEGFB Gene

gene · 549 words

FGF23 — Fibroblast Growth Factor 23

gene · 3323 words

FLT1 Gene

gene · 2316 words

FGF-2 Protein (bFGF)

protein · 1475 words

VEGFR1 (FLT1) Protein

protein · 1308 words

TGFB2 Gene

gene · 990 words

Pathway Diagram

graph TD
    VEGFB["<b>VEGFB</b>"]
    Als{"Als"}
    VEGFB -->|"activates"| Als
    Metabolic_Syndrome{"Metabolic Syndrome"}
    VEGFB -->|"regulates"| Metabolic_Syndrome
    Arthritis{"Arthritis"}
    VEGFB -->|"activates"| Arthritis
    ALS{"ALS"}
    VEGFB -->|"activates"| ALS
    Angiogenesis(["Angiogenesis"])
    VEGFB -->|"activates"| Angiogenesis
    VEGF["VEGF"]
    VEGFB -->|"activates"| VEGF
    FGF2["FGF2"]
    VEGFB -->|"activates"| FGF2
    RUNX2["RUNX2"]
    VEGFB -->|"activates"| RUNX2
    PDGFRB["PDGFRB"]
    VEGFB -->|"activates"| PDGFRB
    GENES["GENES"]
    VEGFB -->|"activates"| GENES
    ANGPT1["ANGPT1"]
    VEGFB -->|"activates"| ANGPT1
    BMP2["BMP2"]
    VEGFB -->|"activates"| BMP2
    BMP2 -->|"activates"| VEGFB
    VEGF -->|"activates"| VEGFB
    FGF2 -->|"activates"| VEGFB
    ANGPT1 -->|"activates"| VEGFB
    PDGFRB -->|"activates"| VEGFB
    PI3K["PI3K"]
    PI3K -->|"activates"| VEGFB
    AKT["AKT"]
    AKT -->|"activates"| VEGFB
    RUNX2 -->|"activates"| VEGFB
    GENES -->|"activates"| VEGFB
    AND["AND"]
    AND -->|"activates"| VEGFB
    style VEGFB fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (71)

TargetRelationTypeStr
Alsactivatesdisease0.75
Arthritisactivatesdisease0.65
Metabolic Syndromeregulatesdisease0.65
ALSactivatesdisease0.65
Nafldactivatesdisease0.65

Incoming (43)

SourceRelationTypeStr
BMP2activatesgene0.60
VEGFactivatesgene0.60
FGF2activatesgene0.60
ANGPT1activatesgene0.60
PDGFRBactivatesgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found