gene

NLGN2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NLGN2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

93Connections
0Hypotheses
0Analyses
50Outgoing
39Incoming

Summary

NLGN2 is a gene implicated in neurodegeneration research. Key relationships include: inhibits, protects against, associated with. Associated with Als, Anxiety, Inflammation. Connected to 51 entities in the SciDEX knowledge graph.

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🧬 Gene Info
Gene SymbolNLGN2
Full NameNeuroligin 2
Chromosome17p13.1
FunctionSynapse Formation: Mediates formation of GABAergic and glycinergic synapses through interaction with presynaptic neurexins.
Subcellular Localization**: Postsynaptic membranes, dendritic shafts
Molecular Weight156 kDa
Amino Acids411 aa
Exons19
UniProt IDQ9NZU5
NCBI Gene ID54587
Ensembl IDENSG00000144048
OMIM607629
GeneCardsNLGN2
Human Protein AtlasNLGN2
Associated DiseasesMigraine
InteractionsDISC1, CYCS, CAT, SLC2A2, SLC2A1, COX4I1
KG Connections93 knowledge graph edges
DatabasesGeneCardsHPASTRING
🔮 Predicted Structure: NLGN2 — AlphaFold Q9NZU5 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (19)

Knowledge base pages for this entity

Canonical Page

NLGN2 Gene

gene · 735 words

Synaptogenesis in Neurodegeneration

mechanism · 2923 words

Neurexin/Neuroligin Synaptic Adhesion Modulator Therapy in Neurodegeneration

mechanism · 2419 words

PDHA1

gene · 2098 words

NLGN3 Gene

gene · 2091 words

NEUROD2 Gene

gene · 1727 words

Pathway Diagram

graph TD
    NLGN2["<b>NLGN2</b>"]
    Als{"Als"}
    NLGN2 -->|"inhibits"| Als
    Anxiety{"Anxiety"}
    NLGN2 -->|"inhibits"| Anxiety
    Schizophrenia{"Schizophrenia"}
    NLGN2 -->|"inhibits"| Schizophrenia
    Ms{"Ms"}
    NLGN2 -->|"inhibits"| Ms
    Migraine{"Migraine"}
    NLGN2 -->|"associated with"| Migraine
    CDK4["CDK4"]
    NLGN2 -->|"associated with"| CDK4
    CHD4["CHD4"]
    NLGN2 -->|"associated with"| CHD4
    HMGCR["HMGCR"]
    NLGN2 -->|"associated with"| HMGCR
    TGFB3["TGFB3"]
    NLGN2 -->|"associated with"| TGFB3
    DISC1["DISC1"]
    NLGN2 -->|"inhibits"| DISC1
    AND["AND"]
    NLGN2 -->|"inhibits"| AND
    neurodegeneration["neurodegeneration"]
    NLGN2 -->|"implicated in"| neurodegeneration
    DISC1 -->|"inhibits"| NLGN2
    ERBB4["ERBB4"]
    ERBB4 -->|"inhibits"| NLGN2
    GENES["GENES"]
    GENES -->|"inhibits"| NLGN2
    GLUD1["GLUD1"]
    GLUD1 -->|"inhibits"| NLGN2
    NRG1["NRG1"]
    NRG1 -->|"inhibits"| NLGN2
    KCNK5["KCNK5"]
    KCNK5 -->|"associated with"| NLGN2
    TGFB1["TGFB1"]
    TGFB1 -->|"associated with"| NLGN2
    TP53["TP53"]
    TP53 -->|"associated with"| NLGN2
    NR1D1["NR1D1"]
    NR1D1 -->|"associated with"| NLGN2
    FXN["FXN"]
    FXN -->|"associated with"| NLGN2
    EPHA5["EPHA5"]
    EPHA5 -->|"associated with"| NLGN2
    EP300["EP300"]
    EP300 -->|"associated with"| NLGN2
    style NLGN2 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (54)

TargetRelationTypeStr
Alsinhibitsdisease0.65
Anxietyinhibitsdisease0.65
Schizophreniainhibitsdisease0.65
Msinhibitsdisease0.65
Migraineassociated_withdisease0.65

Incoming (39)

SourceRelationTypeStr
GENESinhibitsgene0.70
DISC1inhibitsgene0.60
ERBB4inhibitsgene0.60
GLUD1inhibitsgene0.60
NRG1inhibitsgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found