Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about NLGN2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
NLGN2 is a gene implicated in neurodegeneration research. Key relationships include: inhibits, protects against, associated with. Associated with Als, Anxiety, Inflammation. Connected to 51 entities in the SciDEX knowledge graph.
| Gene Symbol | NLGN2 |
| Full Name | Neuroligin 2 |
| Chromosome | 17p13.1 |
| Function | Synapse Formation: Mediates formation of GABAergic and glycinergic synapses through interaction with presynaptic neurexins. |
| Subcellular Localization | **: Postsynaptic membranes, dendritic shafts |
| Molecular Weight | 156 kDa |
| Amino Acids | 411 aa |
| Exons | 19 |
| UniProt ID | Q9NZU5 |
| NCBI Gene ID | 54587 |
| Ensembl ID | ENSG00000144048 |
| OMIM | 607629 |
| GeneCards | NLGN2 |
| Human Protein Atlas | NLGN2 |
| Associated Diseases | Migraine |
| Interactions | DISC1, CYCS, CAT, SLC2A2, SLC2A1, COX4I1 |
| KG Connections | 93 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
NLGN2["<b>NLGN2</b>"]
Als{"Als"}
NLGN2 -->|"inhibits"| Als
Anxiety{"Anxiety"}
NLGN2 -->|"inhibits"| Anxiety
Schizophrenia{"Schizophrenia"}
NLGN2 -->|"inhibits"| Schizophrenia
Ms{"Ms"}
NLGN2 -->|"inhibits"| Ms
Migraine{"Migraine"}
NLGN2 -->|"associated with"| Migraine
CDK4["CDK4"]
NLGN2 -->|"associated with"| CDK4
CHD4["CHD4"]
NLGN2 -->|"associated with"| CHD4
HMGCR["HMGCR"]
NLGN2 -->|"associated with"| HMGCR
TGFB3["TGFB3"]
NLGN2 -->|"associated with"| TGFB3
DISC1["DISC1"]
NLGN2 -->|"inhibits"| DISC1
AND["AND"]
NLGN2 -->|"inhibits"| AND
neurodegeneration["neurodegeneration"]
NLGN2 -->|"implicated in"| neurodegeneration
DISC1 -->|"inhibits"| NLGN2
ERBB4["ERBB4"]
ERBB4 -->|"inhibits"| NLGN2
GENES["GENES"]
GENES -->|"inhibits"| NLGN2
GLUD1["GLUD1"]
GLUD1 -->|"inhibits"| NLGN2
NRG1["NRG1"]
NRG1 -->|"inhibits"| NLGN2
KCNK5["KCNK5"]
KCNK5 -->|"associated with"| NLGN2
TGFB1["TGFB1"]
TGFB1 -->|"associated with"| NLGN2
TP53["TP53"]
TP53 -->|"associated with"| NLGN2
NR1D1["NR1D1"]
NR1D1 -->|"associated with"| NLGN2
FXN["FXN"]
FXN -->|"associated with"| NLGN2
EPHA5["EPHA5"]
EPHA5 -->|"associated with"| NLGN2
EP300["EP300"]
EP300 -->|"associated with"| NLGN2
style NLGN2 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Als | inhibits | disease | 0.65 |
| Anxiety | inhibits | disease | 0.65 |
| Schizophrenia | inhibits | disease | 0.65 |
| Ms | inhibits | disease | 0.65 |
| Migraine | associated_with | disease | 0.65 |
| Neuroinflammation | protects_against | disease | 0.65 |
| Als | protects_against | disease | 0.65 |
| Neurodegeneration | protects_against | disease | 0.65 |
| Inflammation | protects_against | disease | 0.65 |
| ALS | protects_against | disease | 0.65 |
| CDK4 | associated_with | gene | 0.60 |
| CHD4 | associated_with | gene | 0.60 |
| HMGCR | associated_with | gene | 0.60 |
| TGFB3 | associated_with | gene | 0.60 |
| DISC1 | inhibits | gene | 0.60 |
| PSD95 | protects_against | gene | 0.60 |
| CYCS | inhibits | gene | 0.60 |
| CAT | inhibits | gene | 0.60 |
| SLC2A2 | inhibits | gene | 0.60 |
| SLC2A1 | inhibits | gene | 0.60 |
| COX4I1 | inhibits | gene | 0.60 |
| GSK3B | inhibits | gene | 0.60 |
| AKT | protects_against | gene | 0.60 |
| PDHA1 | inhibits | gene | 0.60 |
| GEPHYRIN | interacts_with | gene | 0.60 |
| NLGN1 | inhibits | gene | 0.60 |
| SOD1 | inhibits | gene | 0.60 |
| BDNF | inhibits | gene | 0.60 |
| NRXN3 | inhibits | gene | 0.60 |
| PRKAA1 | inhibits | gene | 0.60 |
| SOD2 | protects_against | gene | 0.60 |
| Rb | inhibits | protein | 0.60 |
| PAX6 | expressed_in | gene | 0.60 |
| SMARCA4 | expressed_in | gene | 0.60 |
| SNAP25 | expressed_in | gene | 0.60 |
| GLUT4 | protects_against | gene | 0.60 |
| OXIDATIVE STRESS | inhibits | gene | 0.60 |
| PER | protects_against | gene | 0.60 |
| Oxidative Stress | inhibits | pathway | 0.60 |
| Neuron | inhibits | cell_type | 0.60 |
| AND | inhibits | gene | 0.60 |
| NEURODEGENERATIVE DISORDERS | protects_against | gene | 0.60 |
| INFLAMMATION | protects_against | gene | 0.60 |
| GENES | inhibits | gene | 0.60 |
| Sod1 | inhibits | pathway | 0.60 |
| Bdnf | inhibits | protein | 0.60 |
| PKM | inhibits | gene | 0.60 |
| Neuron | expressed_in | cell_type | 0.55 |
| SYNAPSE | inhibits | concept | 0.50 |
| Proteins | inhibits | protein | 0.50 |
| Source | Relation | Type | Str |
|---|---|---|---|
| GENES | inhibits | gene | 0.70 |
| DISC1 | inhibits | gene | 0.60 |
| ERBB4 | inhibits | gene | 0.60 |
| GLUD1 | inhibits | gene | 0.60 |
| NRG1 | inhibits | gene | 0.60 |
| KCNK5 | associated_with | gene | 0.60 |
| TGFB1 | associated_with | gene | 0.60 |
| TP53 | associated_with | gene | 0.60 |
| NR1D1 | associated_with | gene | 0.60 |
| FXN | associated_with | gene | 0.60 |
| EPHA5 | associated_with | gene | 0.60 |
| EP300 | associated_with | gene | 0.60 |
| NRXN3 | inhibits | gene | 0.60 |
| PDHA1 | inhibits | gene | 0.60 |
| BDNF | inhibits | gene | 0.60 |
| PRKAA1 | inhibits | gene | 0.60 |
| SOD2 | protects_against | gene | 0.60 |
| SOD1 | inhibits | gene | 0.60 |
| NLGN1 | inhibits | gene | 0.60 |
| CAT | inhibits | gene | 0.60 |
| SLC2A2 | inhibits | gene | 0.60 |
| COX4I1 | inhibits | gene | 0.60 |
| SLC2A1 | inhibits | gene | 0.60 |
| GSK3B | inhibits | gene | 0.60 |
| CYCS | inhibits | gene | 0.60 |
| ADNP | expressed_in | gene | 0.60 |
| NLGN1 | expressed_in | gene | 0.60 |
| ANXIETY | inhibits | gene | 0.60 |
| NEURODEGENERATION | protects_against | gene | 0.60 |
| INFLAMMATION | protects_against | gene | 0.60 |
| NEURODEGENERATIVE DISORDERS | protects_against | gene | 0.60 |
| NEUROINFLAMMATION | protects_against | gene | 0.60 |
| CREB | protects_against | gene | 0.60 |
| SYNAPSE | inhibits | gene | 0.60 |
| PKM | inhibits | gene | 0.60 |
| GLUT4 | protects_against | gene | 0.60 |
| PER | protects_against | gene | 0.60 |
| GEPHYRIN | interacts_with | gene | 0.50 |
| Sod1 | inhibits | gene | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||