Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about TSG101: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | TSG101 |
| Key Genes/Proteins | MAPT, RAB35, TAU PATHOLOGY, AND, CHMP6, ALZHEIMER'S DISEASE |
| Related Diseases | Alzheimer, Tauopathy, Als |
| Related Pathways | oxidative stress response |
Knowledge base pages for this entity
graph TD
TSG101["TSG101"]
TSG101 -->|"regulates"| Tau_Secretion["Tau Secretion"]
TSG101 -->|"activates"| Alzheimer["Alzheimer"]
TSG101 -->|"activates"| Tauopathy["Tauopathy"]
TSG101 -->|"regulates"| RAB35["RAB35"]
TSG101 -->|"activates"| TAU_PATHOLOGY["TAU PATHOLOGY"]
TSG101 -->|"regulates"| AND["AND"]
LYSOSOME["LYSOSOME"] -->|"regulates"| TSG101
RAB7A["RAB7A"] -->|"regulates"| TSG101
ALZHEIMER["ALZHEIMER"] -->|"activates"| TSG101
RAB35 -->|"regulates"| TSG101
TAUOPATHY["TAUOPATHY"] -->|"activates"| TSG101
CHMP6["CHMP6"] -->|"regulates"| TSG101
ENDOSOME["ENDOSOME"] -->|"regulates"| TSG101| Target | Relation | Type | Str |
|---|---|---|---|
| Tau Degradation | regulates | process | 0.80 |
| Tau Secretion | regulates | process | 0.75 |
| MAPT | regulates | protein | 0.75 |
| Alzheimer | activates | disease | 0.65 |
| Tauopathy | activates | disease | 0.65 |
| Tauopathy | stabilizes | disease | 0.65 |
| Alzheimer | stabilizes | disease | 0.65 |
| Als | associated_with | disease | 0.65 |
| oxidative stress response | participates_in | pathway | 0.65 |
| RAB35 | regulates | gene | 0.60 |
| TAU PATHOLOGY | activates | gene | 0.60 |
| AND | regulates | gene | 0.60 |
| CHMP6 | regulates | gene | 0.60 |
| ALZHEIMER'S DISEASE | activates | gene | 0.60 |
| ENDOSOME | regulates | gene | 0.60 |
| TAUOPATHY | activates | gene | 0.60 |
| TAU | regulates | gene | 0.60 |
| RAB7A | regulates | gene | 0.60 |
| Actin | stabilizes | protein | 0.60 |
| Tau Protein | stabilizes | protein | 0.60 |
| Raf | regulates | protein | 0.60 |
| Actin | activates | protein | 0.60 |
| EXOSOMES | associated_with | gene | 0.60 |
| Epithelial | associated_with | cell_type | 0.60 |
| ubiquitin-proteasome | participates_in | pathway | 0.55 |
| Source | Relation | Type | Str |
|---|---|---|---|
| LYSOSOME | regulates | gene | 0.60 |
| RAB7A | regulates | gene | 0.60 |
| ALZHEIMER | activates | gene | 0.60 |
| RAB35 | regulates | gene | 0.60 |
| TAUOPATHY | activates | gene | 0.60 |
| CHMP6 | regulates | gene | 0.60 |
| ENDOSOME | regulates | gene | 0.60 |
| ALZHEIMER | stabilizes | gene | 0.60 |
| TAU | regulates | gene | 0.60 |
| TAUOPATHY | stabilizes | gene | 0.60 |
| CD63 | activates | gene | 0.60 |
| CD9 | activates | gene | 0.60 |
| RAB35 | activates | gene | 0.60 |
| UGCG | activates | gene | 0.60 |
| RAB5 | activates | gene | 0.60 |
| CD63 | biomarker_for | gene | 0.55 |
| CD81 | biomarker_for | gene | 0.55 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||