gene

ULK3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ULK3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

19Connections
0Hypotheses
0Analyses
9Outgoing
10Incoming
0Experiments

Summary

ULK3 is a gene implicated in neurodegeneration research. Key relationships include: therapeutic target, expressed in, implicated in. Associated with Als, Cancer, Ms. Connected to 16 entities in the SciDEX knowledge graph.

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🧬 Gene Info
Gene SymbolULK3
Full NameUnc-51 Like Kinase 3
Chromosome19q13.43
Functionis an important component in the neurobiology of neurodegenerative diseases.
Primary Expressionvarious brain regions:
Molecular Weight102 kDa
Amino Acids300 aa
PathwaysAMPK, mTOR, mtor, PI3K
UniProt IDQ6ZNE5
NCBI Gene ID54586
Ensembl IDENSG00000140474
OMIM608866
GeneCardsULK3
Human Protein AtlasULK3
Associated Diseasesneurodegeneration
InteractionsAND, BIN1
KG Connections19 knowledge graph edges
DatabasesGeneCardsHPASTRING
🔮 Predicted Structure: ULK3 — AlphaFold Q6ZNE5 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (7)

Knowledge base pages for this entity

Canonical Page

ULK3 Gene

gene · 957 words

SUFU — Suppressor of Fused, Hedgehog Pathway Regulator

gene · 1621 words

mTOR Signaling Pathway in Neurodegeneration

mechanism · 1574 words

ULK4 Gene

gene · 1446 words

ULK3 Protein

protein · 1231 words

Proteins

index · 296 words

Pathway Diagram

graph TD
    ULK3["<b>ULK3</b>"]
    Als{"Als"}
    ULK3 -->|"therapeutic target"| Als
    Ms{"Ms"}
    ULK3 -->|"therapeutic target"| Ms
    Cancer{"Cancer"}
    ULK3 -->|"therapeutic target"| Cancer
    Tumor{"Tumor"}
    ULK3 -->|"therapeutic target"| Tumor
    DDIT3["DDIT3"]
    ULK3 -->|"expressed in"| DDIT3
    Akt(["Akt"])
    ULK3 -->|"therapeutic target"| Akt
    Pi3K(["Pi3K"])
    ULK3 -->|"therapeutic target"| Pi3K
    neurodegeneration["neurodegeneration"]
    ULK3 -->|"implicated in"| neurodegeneration
    TP53["TP53"]
    TP53 -->|"therapeutic target"| ULK3
    SRC["SRC"]
    SRC -->|"therapeutic target"| ULK3
    PI3K["PI3K"]
    PI3K -->|"therapeutic target"| ULK3
    AKT["AKT"]
    AKT -->|"therapeutic target"| ULK3
    AKT1["AKT1"]
    AKT1 -->|"therapeutic target"| ULK3
    IMMUNE_INFILTRATION["IMMUNE INFILTRATION"]
    IMMUNE_INFILTRATION -->|"therapeutic target"| ULK3
    CANCER["CANCER"]
    CANCER -->|"therapeutic target"| ULK3
    DRD4["DRD4"]
    DRD4 -->|"expressed in"| ULK3
    style ULK3 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (9)

TargetRelationTypeStr
Alstherapeutic_targetdisease0.65
Mstherapeutic_targetdisease0.65
Cancertherapeutic_targetdisease0.65
Tumortherapeutic_targetdisease0.65
DDIT3expressed_ingene0.60

Incoming (10)

SourceRelationTypeStr
TP53therapeutic_targetgene0.60
SRCtherapeutic_targetgene0.60
PI3Ktherapeutic_targetgene0.60
AKTtherapeutic_targetgene0.60
AKT1therapeutic_targetgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

ExperimentTypeDiseaseScoreFeasibilityModelStatusEst. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found