Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about ULK3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
ULK3 is a gene implicated in neurodegeneration research. Key relationships include: therapeutic target, expressed in, implicated in. Associated with Als, Cancer, Ms. Connected to 16 entities in the SciDEX knowledge graph.
| Gene Symbol | ULK3 |
| Full Name | Unc-51 Like Kinase 3 |
| Chromosome | 19q13.43 |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Primary Expression | various brain regions: |
| Molecular Weight | 102 kDa |
| Amino Acids | 300 aa |
| Pathways | AMPK, mTOR, mtor, PI3K |
| UniProt ID | Q6ZNE5 |
| NCBI Gene ID | 54586 |
| Ensembl ID | ENSG00000140474 |
| OMIM | 608866 |
| GeneCards | ULK3 |
| Human Protein Atlas | ULK3 |
| Associated Diseases | neurodegeneration |
| Interactions | AND, BIN1 |
| KG Connections | 19 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
ULK3["<b>ULK3</b>"]
Als{"Als"}
ULK3 -->|"therapeutic target"| Als
Ms{"Ms"}
ULK3 -->|"therapeutic target"| Ms
Cancer{"Cancer"}
ULK3 -->|"therapeutic target"| Cancer
Tumor{"Tumor"}
ULK3 -->|"therapeutic target"| Tumor
DDIT3["DDIT3"]
ULK3 -->|"expressed in"| DDIT3
Akt(["Akt"])
ULK3 -->|"therapeutic target"| Akt
Pi3K(["Pi3K"])
ULK3 -->|"therapeutic target"| Pi3K
neurodegeneration["neurodegeneration"]
ULK3 -->|"implicated in"| neurodegeneration
TP53["TP53"]
TP53 -->|"therapeutic target"| ULK3
SRC["SRC"]
SRC -->|"therapeutic target"| ULK3
PI3K["PI3K"]
PI3K -->|"therapeutic target"| ULK3
AKT["AKT"]
AKT -->|"therapeutic target"| ULK3
AKT1["AKT1"]
AKT1 -->|"therapeutic target"| ULK3
IMMUNE_INFILTRATION["IMMUNE INFILTRATION"]
IMMUNE_INFILTRATION -->|"therapeutic target"| ULK3
CANCER["CANCER"]
CANCER -->|"therapeutic target"| ULK3
DRD4["DRD4"]
DRD4 -->|"expressed in"| ULK3
style ULK3 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Als | therapeutic_target | disease | 0.65 |
| Ms | therapeutic_target | disease | 0.65 |
| Cancer | therapeutic_target | disease | 0.65 |
| Tumor | therapeutic_target | disease | 0.65 |
| DDIT3 | expressed_in | gene | 0.60 |
| Akt | therapeutic_target | pathway | 0.60 |
| Pi3K | therapeutic_target | pathway | 0.60 |
| AND | activates | gene | 0.60 |
| Neuron | expressed_in | cell_type | 0.55 |
| Source | Relation | Type | Str |
|---|---|---|---|
| TP53 | therapeutic_target | gene | 0.60 |
| SRC | therapeutic_target | gene | 0.60 |
| PI3K | therapeutic_target | gene | 0.60 |
| AKT | therapeutic_target | gene | 0.60 |
| AKT1 | therapeutic_target | gene | 0.60 |
| DRD4 | expressed_in | gene | 0.60 |
| BIN1 | activates | gene | 0.60 |
| IMMUNE INFILTRATION | therapeutic_target | gene | 0.60 |
| CANCER | therapeutic_target | gene | 0.60 |
| AND | activates | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||