gene

WNT5A

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about WNT5A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

19Connections
0Hypotheses
0Analyses
11Outgoing
8Incoming
0Experiments

Summary

Page for WNT5A Gene

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🧬 Gene Info
Gene SymbolWNT5A
Full NameWnt Family Member 5A
Chromosome3p14.3
FunctionWNT5A encodes a member of the Wnt family of secreted signaling molecules that play critical roles in embryonic development, cell polarity, migration, and tissue patterning.
Primary Expressionthe cortical marginal zone, intermediate zone, and subventricular zone, regulating neuronal migration
Molecular Weight40 kDa
Amino Acids380 aa
Pathwayswnt, WNT, Wnt, wNT, Wnt Signaling
UniProt IDQ9H0J5
Ensembl IDENSG00000114270
GeneCardsWNT5A
Human Protein AtlasWNT5A
Associated DiseasesAlzheimer's disease, Parkinson's disease, ALS
InteractionsTAU, INFLAMMATION, OXIDATIVE STRESS, KRAS, WNT, DEMENTIA
KG Connections19 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING
🔮 Predicted Structure: WNT5A — AlphaFold Q9H0J5 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

WNT5A Gene

gene · 564 words

Wnt Non-Canonical Signaling Pathways in Neurodegeneration

mechanism · 4664 words

Wnt-Beta-Catenin Signaling Dysfunction Hypothesis in Parkinson's Disease

hypothesis · 3146 words

Neuronal Migration

mechanism · 3104 words

Wnt Signaling in Neurodegeneration

mechanism · 3016 words

DVL3 — Dishevelled Segment Polarity Protein 3

gene · 2849 words

Pathway Diagram

graph TD
    WNT5A["WNT5A"]
    Dementia{"Dementia"}
    WNT5A -->|"activates"| Dementia
    Alzheimer{"Alzheimer"}
    WNT5A -->|"activates"| Alzheimer
    Inflammation{"Inflammation"}
    WNT5A -->|"activates"| Inflammation
    Ms{"Ms"}
    WNT5A -->|"activates"| Ms
    Als{"Als"}
    WNT5A -->|"activates"| Als
    TAU["TAU"]
    WNT5A -->|"activates"| TAU
    INFLAMMATION["INFLAMMATION"]
    WNT5A -->|"activates"| INFLAMMATION
    Oxidative_Stress(["Oxidative Stress"])
    WNT5A -->|"activates"| Oxidative_Stress
    Wnt(["Wnt"])
    WNT5A -->|"activates"| Wnt
    Long_Term_Potentiation(["Long-Term Potentiation"])
    WNT5A -->|"activates"| Long_Term_Potentiation
    Tau_Phosphorylation(["Tau Phosphorylation"])
    WNT5A -->|"activates"| Tau_Phosphorylation
    OXIDATIVE_STRESS["OXIDATIVE STRESS"]
    OXIDATIVE_STRESS -->|"activates"| WNT5A
    KRAS["KRAS"]
    KRAS -->|"activates"| WNT5A
    WNT["WNT"]
    WNT -->|"activates"| WNT5A
    DEMENTIA["DEMENTIA"]
    DEMENTIA -->|"activates"| WNT5A

Outgoing (11)

TargetRelationTypeStr
Dementiaactivatesdisease0.65
Alzheimeractivatesdisease0.65
Inflammationactivatesdisease0.65
Msactivatesdisease0.65
Alsactivatesdisease0.65

Incoming (8)

SourceRelationTypeStr
WNT3Aexpressed_ingene0.60
OXIDATIVE STRESSactivatesgene0.60
KRASactivatesgene0.60
WNTactivatesgene0.60
DEMENTIAactivatesgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

ExperimentTypeDiseaseScoreFeasibilityModelStatusEst. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found