Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about WNT5A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Gene Symbol | WNT5A |
| Full Name | Wnt Family Member 5A |
| Chromosome | 3p14.3 |
| Function | WNT5A encodes a member of the Wnt family of secreted signaling molecules that play critical roles in embryonic development, cell polarity, migration, and tissue patterning. |
| Primary Expression | the cortical marginal zone, intermediate zone, and subventricular zone, regulating neuronal migration |
| Molecular Weight | 40 kDa |
| Amino Acids | 380 aa |
| Pathways | wnt, WNT, Wnt, wNT, Wnt Signaling |
| UniProt ID | Q9H0J5 |
| Ensembl ID | ENSG00000114270 |
| GeneCards | WNT5A |
| Human Protein Atlas | WNT5A |
| Associated Diseases | Alzheimer's disease, Parkinson's disease, ALS |
| Interactions | TAU, INFLAMMATION, OXIDATIVE STRESS, KRAS, WNT, DEMENTIA |
| KG Connections | 19 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
WNT5A["WNT5A"]
Dementia{"Dementia"}
WNT5A -->|"activates"| Dementia
Alzheimer{"Alzheimer"}
WNT5A -->|"activates"| Alzheimer
Inflammation{"Inflammation"}
WNT5A -->|"activates"| Inflammation
Ms{"Ms"}
WNT5A -->|"activates"| Ms
Als{"Als"}
WNT5A -->|"activates"| Als
TAU["TAU"]
WNT5A -->|"activates"| TAU
INFLAMMATION["INFLAMMATION"]
WNT5A -->|"activates"| INFLAMMATION
Oxidative_Stress(["Oxidative Stress"])
WNT5A -->|"activates"| Oxidative_Stress
Wnt(["Wnt"])
WNT5A -->|"activates"| Wnt
Long_Term_Potentiation(["Long-Term Potentiation"])
WNT5A -->|"activates"| Long_Term_Potentiation
Tau_Phosphorylation(["Tau Phosphorylation"])
WNT5A -->|"activates"| Tau_Phosphorylation
OXIDATIVE_STRESS["OXIDATIVE STRESS"]
OXIDATIVE_STRESS -->|"activates"| WNT5A
KRAS["KRAS"]
KRAS -->|"activates"| WNT5A
WNT["WNT"]
WNT -->|"activates"| WNT5A
DEMENTIA["DEMENTIA"]
DEMENTIA -->|"activates"| WNT5A| Target | Relation | Type | Str |
|---|---|---|---|
| Dementia | activates | disease | 0.65 |
| Alzheimer | activates | disease | 0.65 |
| Inflammation | activates | disease | 0.65 |
| Ms | activates | disease | 0.65 |
| Als | activates | disease | 0.65 |
| TAU | activates | gene | 0.60 |
| INFLAMMATION | activates | gene | 0.60 |
| Oxidative Stress | activates | pathway | 0.60 |
| Wnt | activates | pathway | 0.60 |
| Long-Term Potentiation | activates | pathway | 0.60 |
| Tau Phosphorylation | activates | pathway | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| WNT3A | expressed_in | gene | 0.60 |
| OXIDATIVE STRESS | activates | gene | 0.60 |
| KRAS | activates | gene | 0.60 |
| WNT | activates | gene | 0.60 |
| DEMENTIA | activates | gene | 0.60 |
| ALZHEIMER | activates | gene | 0.60 |
| AND | activates | gene | 0.60 |
| ALZHEIMER'S DISEASE | activates | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||