pathway

Tau Phosphorylation

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about Tau Phosphorylation: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

427Connections

0Hypotheses

0Analyses

26Outgoing

50Incoming

No summary available yet. View on Wiki →

🔀 Pathway Info

Name	Tau Phosphorylation
Key Genes/Proteins	TAU, SYK, STING, LARS2
Related Diseases	Alzheimer's Disease, Microtubule Instability, Neurofibrillary Tangles

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    Tau_Phosphorylation["Tau Phosphorylation"] -->|"associated"| Alzheimer_s_Disease["Alzheimer's Disease"]
    style Alzheimer_s_Disease fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#e0e0e0
    Tau_Phosphorylation["Tau Phosphorylation"] -->|"contributes to"| Neurofibrillary_Tangles["Neurofibrillary Tangles"]
    style Neurofibrillary_Tangles fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#e0e0e0
    Tau_Phosphorylation["Tau Phosphorylation"] -->|"contributes to"| Alzheimer_s_Disease_Neuropatho["Alzheimer's Disease Neuropathology"]
    style Alzheimer_s_Disease_Neuropatho fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    Tau_Phosphorylation["Tau Phosphorylation"] -->|"causes"| Redox_Imbalance["Redox Imbalance"]
    style Redox_Imbalance fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#e0e0e0
    Lumacaftor["Lumacaftor"] -.->|"inhibits"| Tau_Phosphorylation["Tau Phosphorylation"]
    style Lumacaftor fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#e0e0e0
    GSK3__["GSK3-beta"] -->|"regulates"| Tau_Phosphorylation["Tau Phosphorylation"]
    style GSK3__ fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    Chronic_Sleep_Deprivation["Chronic Sleep Deprivation"] -->|"causes"| Tau_Phosphorylation["Tau Phosphorylation"]
    style Chronic_Sleep_Deprivation fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#e0e0e0
    GMPR1["GMPR1"] -->|"associated"| Tau_Phosphorylation["Tau Phosphorylation"]
    style GMPR1 fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    GMPR["GMPR"] -->|"modulates"| Tau_Phosphorylation["Tau Phosphorylation"]
    style GMPR fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    style Tau_Phosphorylation fill:#1b5e20,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold

Outgoing (53)

Target	Relation	Type	Str
TAU	modulates	protein	0.95
Alzheimer's Disease	associated_with	disease	0.90
Microtubule Instability	causes	phenotype	0.90
Alzheimer's Disease	contributes_to	disease	0.90
Neurofibrillary Tangles	contributes_to	phenotype	0.85
Neuronal Degeneration	causes	process	0.85
Tau Aggregation	associated_with	process	0.85
Neurodegeneration	contributes_to	process	0.85
Alzheimer's Disease Neuropathology	contributes_to	mechanism	0.80
Alzheimer'S Disease	contributes_to	disease	0.80
Alzheimer's Disease	biomarker_for	disease	0.80
Redox Imbalance	causes	process	0.75
GSK3	regulates	concept	0.50
AMYLOID-β	regulates	concept	0.50
Infection	associated_with	disease	0.50
ORGANOIDS	associated_with	concept	0.50
Proteins	activates	protein	0.50
Nlrp3 Inflammasome	activates	pathway	0.50
Nlrp3 Inflammasome	causes	pathway	0.50
IPSC	inhibits	concept	0.50
GLIOSIS	associated_with	concept	0.50
IPSC	expressed_in	concept	0.50
INSULIN	activates	concept	0.50
AMYLOID-β	inhibits	concept	0.50
Neuron	associated_with	cell_type	0.50
Microglia	associated_with	cell_type	0.50

Incoming (374)

Source	Relation	Type	Str
SYK	regulates	gene	0.95
R406	inhibits	drug	0.95
miR-219-5p	mediates	biomarker	0.95
Lumacaftor	inhibits	drug	0.90
STING	upregulates	protein	0.90
LARS2	inhibits	gene	0.90
BAY 61-3606	inhibits	drug	0.90
miR-219-5p	activates	biomarker	0.90
Ceramide	promotes	compound	0.90
Chronic Sleep Deprivation	causes	process	0.85
GMPR1	associated_with	protein	0.85
PP2A	downregulates	protein	0.85
TBK1	mediates	protein	0.85
Lipopolysaccharide	associated_with	compound	0.85
NLRP3 Inflammasome	mediates	pathway	0.85
Amyloid-β	associated_with	compound	0.85
GSK3B	mediates	protein	0.85
MAPK14	mediates	protein	0.85
TTBK1	involved_in	enzyme	0.85
GSK-3β	involved_in	enzyme	0.85
Brain Cholesterol Accumulation	promotes	phenotype	0.85
GMPR	modulates	gene	0.80
Oxidative Stress	upregulates	process	0.80
Hyperbaric Oxygen Therapy	inhibits	drug	0.80
GSK3B	upregulates	protein	0.80
Rg1	inhibits	compound	0.80
Abeta	contributes_to	compound	0.80
MIR-125B	upregulates	gene	0.80
MIR-132	inhibits	gene	0.80
MIR-212	inhibits	gene	0.80
Glucocorticoid Receptor	regulates	receptor	0.75
PRESENILIN	associated_with	gene	0.60
AMPK	associated_with	gene	0.60
NPTX2	therapeutic_target	gene	0.60
WIF1	therapeutic_target	gene	0.60
AMYLOID	regulates	gene	0.60
ALZHEIMER'S DISEASE	expressed_in	gene	0.60
AMYLOID-Β PLAQUES	expressed_in	gene	0.60
TAU	regulates	gene	0.60
PRESENILIN	expressed_in	gene	0.60
ALZHEIMER	expressed_in	gene	0.60
TAU PATHOLOGY	expressed_in	gene	0.60
TAUOPATHY	expressed_in	gene	0.60
DEMENTIA	expressed_in	gene	0.60
NEURODEGENERATIVE DISORDERS	expressed_in	gene	0.60
AGING	expressed_in	gene	0.60
AMYLOID	activates	gene	0.60
ALZHEIMER'S DISEASE	activates	gene	0.60
MICROTUBULES	activates	gene	0.60
NEURODEGENERATIVE DISEASES	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Tau Phosphorylation

Understanding Entity Pages

Wiki Pages (20)

cbs-psp-daily-action-plan

Personalized Treatment Plan — Atypical Parkinsonism (CBS/PSP)

Progressive Supranuclear Palsy (PSP)

Corticobasal Syndrome (CBS)

Novel Therapy Index

CBS/PSP Supplements Guide

Device Therapies Comparison for CBS/PSP

Section 148: Advanced Nutritional Biochemistry in CBS/PSP

Myoclonus and Cortical Hyperexcitability in Corticobasal Syndrome

Corticobasal Degeneration (CBD)

nhp-validation-animal-model

PI-2620 Tau PET in PSP

Section 162: Advanced Antioxidant and Redox Therapy in CBS/PSP

Frontotemporal Dementia (FTD) Mechanistic Pathway

CBS/PSP Treatment Rankings

Alzheimer's Disease

Frontotemporal Dementia (FTD)

coq10-neurodegeneration