Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about IRON: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | IRON |
| Summary | Page for Iron-Laden Microglia |
| Related Diseases | FERROPTOSIS, ROS, CANCER |
| Linked Hypotheses | 2 hypotheses |
Knowledge base pages for this entity
graph TD
IRON["IRON"]
IRON -->|"causes"| Ferroptosis["Ferroptosis"]
IRON -->|"causes"| Phospholipid_Peroxidation["Phospholipid Peroxidation"]
IRON -->|"upregulates"| Glycolysis["Glycolysis"]
IRON -->|"mediates"| SNCA["SNCA"]
IRON -->|"expressed in"| Brain["Brain"]
Hemoglobin["Hemoglobin"] -->|"binds"| IRON
Ferroportin["Ferroportin"] -->|"mediates"| IRON
Ferritin["Ferritin"] -->|"binds"| IRON
TFR1["TFR1"] -->|"mediates"| IRON
TF["TF"] -->|"binds"| IRON
Transferrin["Transferrin"] -->|"binds"| IRON
Ferroptosis -->|"involved_in"| IRON
ALOX15["ALOX15"] -->|"binds"| IRON| Target | Relation | Type | Str |
|---|---|---|---|
| FERROPTOSIS | causes | phenotype | 0.72 |
| FERROPTOSIS | activates | phenotype | 0.72 |
| ROS | activates | phenotype | 0.64 |
| Source | Relation | Type | Str |
|---|---|---|---|
| CANCER | associated_with | disease | 0.64 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Hepcidin-Iron Set Point Hypothesis | 0.511 | endocrinology | Does TRT-induced erythrocytosis actually |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-15 | 2 hypotheses Top: 0.586
neurodegeneration | 2026-04-10 | 0 hypotheses
neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.507
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||