Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about apoe2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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Knowledge base pages for this entity
graph TD
apoe2["<b>apoe2</b>"]
APOE3(["APOE3"])
apoe2 -->|"activates"| APOE3
APOE4(["APOE4"])
apoe2 -->|"activates"| APOE4
APOE(["APOE"])
apoe2 -->|"activates"| APOE
AMYLOID(["AMYLOID"])
apoe2 -->|"activates"| AMYLOID
AMYLOID__["AMYLOID-beta"]
apoe2 -->|"activates"| AMYLOID__
Neurodegeneration{"Neurodegeneration"}
apoe2 -.->|"inhibits"| Neurodegeneration
Neuroinflammation["Neuroinflammation"]
Neuroinflammation -.->|"inhibits"| apoe2
style apoe2 fill:#1a3a4a,stroke:#ef5350,stroke-width:3px,color:#ef5350| Target | Relation | Type | Str |
|---|---|---|---|
| APOE4 | activates | gene | 0.50 |
| APOE | activates | gene | 0.50 |
| APOE | inhibits | gene | 0.50 |
| LDLR | inhibits | gene | 0.50 |
| APOE4 | interacts_with | gene | 0.50 |
| late | interacts_with | disease | 0.50 |
| APOE | interacts_with | gene | 0.50 |
| BDNF | associated_with | gene | 0.50 |
| APOE4 | associated_with | gene | 0.50 |
| APOE | associated_with | gene | 0.50 |
| APOE3 | activates | protein | 0.50 |
| AMYLOID | activates | gene | 0.50 |
| AMYLOID-β | activates | concept | 0.50 |
| Neurodegeneration | inhibits | disease | 0.50 |
| ALZHEIMER | inhibits | gene | 0.50 |
| AMYLOID | inhibits | gene | 0.50 |
| Alzheimer Disease | inhibits | disease | 0.50 |
| disease | inhibits | disease | 0.50 |
| APOE3 | inhibits | protein | 0.50 |
| APOE3 | interacts_with | protein | 0.50 |
| NEURONS | interacts_with | concept | 0.50 |
| APOE3 | associated_with | protein | 0.50 |
| disease | activates | disease | 0.50 |
| Source | Relation | Type | Str |
|---|---|---|---|
| Neuroinflammation | inhibits | process | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||