concept

OLIGODENDROCYTES

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about OLIGODENDROCYTES: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1082Connections

4Hypotheses

5Analyses

50Outgoing

50Incoming

4Experiments

12Debates

Summary

OLIGODENDROCYTES is a concept in neurodegeneration research. Key relationships include: co discussed, expressed in, activates. Associated with CANCER, DEMENTIA, NEURODEGENERATION. Connected to 80 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	OLIGODENDROCYTES
Key Genes/Proteins	ABCA1, ACHE, AD, ADAM10, ALS, AMPK
Related Diseases	ALZHEIMER, Alzheimer'S Disease, ALZHEIMER'S DISEASE, AMYOTROPHIC LATERAL SCLEROSIS

Wiki Pages (1)

Knowledge base pages for this entity

Oligodendrocytes

cell · 4838 words

Pathway Diagram

graph TD
    OLIGODENDROCYTES["OLIGODENDROCYTES"]
    OLIGODENDROCYTES -->|"produces"| myelin["myelin"]
    OLIGODENDROCYTES -->|"expressed in"| Prosaposin["Prosaposin"]
    OLIGODENDROCYTES -->|"activates"| NEUROINFLAMMATION["NEUROINFLAMMATION"]
    OLIGODENDROCYTES -->|"causes"| NEURODEGENERATION["NEURODEGENERATION"]
    OLIGODENDROCYTES -->|"activates"| neuroinflammation["neuroinflammation"]
    OLIGODENDROCYTES -->|"activates"| neurodegeneration["neurodegeneration"]
    OLIGODENDROCYTES -->|"secretes"| IL6["IL6"]
    OLIGODENDROCYTES -->|"causes"| PARKIN["PARKIN"]
    OLIGODENDROCYTES -->|"causes"| PARKINSON["PARKINSON"]
    OLIGODENDROCYTES -->|"causes"| PARKINSON_S["PARKINSON'S"]
    HSPA1A["HSPA1A"] -->|"expressed in"| OLIGODENDROCYTES
    Microglia["Microglia"] -->|"interacts"| OLIGODENDROCYTES
    OxPC["OxPC"] -->|"causes"| OLIGODENDROCYTES
    BIN1["BIN1"] -->|"expressed in"| OLIGODENDROCYTES
    GPR37["GPR37"] -->|"expressed in"| OLIGODENDROCYTES
    DOPAMINERGIC_NEURONS["DOPAMINERGIC_NEURONS"] -->|"interacts"| OLIGODENDROCYTES
    OXPCS["OXPCS"] -->|"inhibits"| OLIGODENDROCYTES
    OxPCs["OxPCs"] -->|"causes"| OLIGODENDROCYTES
    AQP4["AQP4"] -->|"activates"| OLIGODENDROCYTES
    ASTROCYTE["ASTROCYTE"] -->|"activates"| OLIGODENDROCYTES
    ASTROCYTES["ASTROCYTES"] -->|"activates"| OLIGODENDROCYTES
    COMPLEMENT["COMPLEMENT"] -->|"activates"| OLIGODENDROCYTES

Outgoing (285)

Target	Relation	Type	Str
ds-f2c28aed24a7	provides_data_for	dataset	1.00
ds-f2c28aed24a7	data_in	dataset	1.00
Neuroinflammation	causes	process	0.95
Metabolic Reallocation	involved_in	process	0.95
Myelin	associated_with	process	0.95
Alzheimer's Disease	involved_in	disease	0.95
Neuroinflammation	associated_with	process	0.95
Neurodegeneration	associated_with	process	0.95
Neuroinflammation	mediates	process	0.90
myelin	produces	protein	0.90
Tau Pathology	interacts_with	process	0.90
Parkinson's Disease	contributes_to	disease	0.90
TAU	interacts_with	protein	0.90
Alzheimer's Disease Pathogenesis	contributes_to	process	0.90
Neurodegeneration	mediates	process	0.90
Amyloid Pathology	interacts_with	process	0.90
multiple sclerosis	associated_with	disease	0.90
Myelin Degeneration	contributes_to	process	0.90
Disease Progression	contributes_to	process	0.85
Dna Damage Response	expressed_in	pathway	0.85
Inflammation	modulates	process	0.85
Brain Ageing	associated_with	process	0.85
Stress Response	associated_with	process	0.85
Vascular Dementia	involved_in	disease	0.85
Alzheimer'S Disease	contributes_to	disease	0.85
sphingolipid metabolism	active_in	pathway	0.85
Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease	involved_in	disease	0.85
Immune Modulation	mediates	process	0.85
MS lesions	expressed_in	process	0.80
Cellular Survival	mediates	process	0.80
Oxidative Stress	involved_in	process	0.80
neurodegeneration	associated_with	process	0.80
Synaptic Dysfunction	contributes_to	process	0.80
multiple sclerosis	inhibits	disease	0.80
demyelination	implicated_in	process	0.80
Alzheimer'S Disease	protects_against	disease	0.80
Prosaposin	expressed_in	protein	0.80
multiple sclerosis	activates	disease	0.80
neurons	interacts_with	cell_type	0.80
NEUROINFLAMMATION	drives	process	0.80
unfolded protein response	active_in	pathway	0.75
COHESIN COMPLEX	expressed_in	protein	0.75
Defense Mechanisms	mediates	process	0.75
Apoptosis	protects_against	process	0.75
neurodegeneration	activates	phenotype	0.72
NEURODEGENERATION	activates	phenotype	0.72
NEURODEGENERATION	causes	phenotype	0.72
NEUROINFLAMMATION	activates	phenotype	0.72
neuroinflammation	activates	phenotype	0.72
TREM2	activates	gene	0.70

Incoming (797)

Source	Relation	Type	Str
ds-f2c28aed24a7	data_in	dataset	1.00
NEURON	activates	cell_type	0.95
MICROGLIA	regulates	cell_type	0.95
NEURON	regulates	cell_type	0.95
33440165	shuttle	paper	0.90
36385529	aberrantly deposited in	paper	0.90
Oligodendrocyte Precursor Cells	involved_in	cell_type	0.90
Oxidized Phosphatidylcholines	mediates	compound	0.90
34225562	show vulnerability and myelin alterations	paper	0.90
38503282	accumulated indels slower than	paper	0.90
38503282	accumulated sSNVs faster than	paper	0.90
BDNF	promotes	gene	0.90
38503282	accumulate indels slower than	paper	0.90
Oxidized Phosphatidylcholines	targets	compound	0.90
HSPA1A	expressed_in	gene	0.90
axon	found_in	organelle	0.90
FERROPTOSIS	affects	process	0.90
38503282	accumulate sSNVs faster than	paper	0.90
OxPC	mediates	compound	0.90
MOG	expressed_in	gene	0.90
SMS2	expressed_in	gene	0.90
aging	affects	disease	0.90
multiple sclerosis	affects	disease	0.90
neuroinflammation	affects	disease	0.90
Alzheimer's disease	affects	disease	0.90
neurodegeneration	affects	disease	0.90
lipid metabolism	active_in	pathway	0.90
unfolded protein response	active_in	pathway	0.90
GPR37	expressed_in	gene	0.88
Astrocytes	interacts_with	cell_type	0.85
PIEZO1	regulates	protein	0.85
GBA1	expressed_in	gene	0.85
Oligonucleotide Transport Vehicle	expressed_in	drug	0.85
Microglia	interacts_with	cell_type	0.85
BIN1	expressed_in	gene	0.80
Piezo1	regulates	gene	0.80
complement cascade	active_in	pathway	0.80
AQP4	expressed_in	gene	0.80
Parkinson's disease	affects	disease	0.80
SGMS1	associated_with	gene	0.80
BIN1	expressed_in	protein	0.80
SMPD1	expressed_in	gene	0.80
Remyelinating Agents	targets	drug	0.80
MBP	expressed_in	gene	0.80
RNA	expressed_in	gene	0.80
SGMS1	regulates	gene	0.80
NLRP3	expressed_in	gene	0.80
NLRP3	regulates	gene	0.80
NLRP3	activates	gene	0.80
pyroptosis	active_in	pathway	0.80

Targeting Hypotheses (4)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
ACSL4-Ferroptotic Priming in Stressed Oligodendrocytes Drive	0.801	alzheimers	Cell type vulnerability in Alzheimers Di
ACSL4-Driven Ferroptotic Priming in Disease-Associated Oligo	0.779	alzheimers	Cell type vulnerability in Alzheimers Di
PDE4 Inhibition as Inflammatory Reset for PD Oligodendrocyte	0.779	neuroinflammation	How do oligodendrocytes initiate neuroin
ALOX15-Driven Enzymatic Ferroptosis in AD Oligodendrocytes v	0.772	alzheimers	Cell type vulnerability in Alzheimers Di

Mentioning Analyses (5)

Scientific analyses that reference this entity

How do oligodendrocytes initiate neuroinflammation in PD when microglia are trad

neuroinflammation | 2026-04-13 | 2 hypotheses Top: 0.831

Is myelin loss in AD causal or an adaptive response to neuronal damage?

neurodegeneration | 2026-04-11 | 0 hypotheses

Gene expression changes in aging mouse brain predicting neurodegenerative vulner

neurodegeneration | 2026-04-03 | 43 hypotheses Top: 0.893

Cell type vulnerability in Alzheimer's Disease (SEA-AD data)

neurodegeneration | 2026-04-03 | 5 hypotheses Top: 0.606

Cell type vulnerability in Alzheimers Disease (SEA-AD transcriptomic data)

neurodegeneration | 2026-04-03 | 19 hypotheses Top: 0.891

Experiments (4)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
SIRPα modulation in mouse models of Alzheimer's disease	validation	Alzheimer's disease	0.900	0.00	mouse models of Alzheimer's di	proposed	N/A
Microglial SIRPα expression in human Alzheimer's disease tissue	exploratory	Alzheimer's disease	0.800	0.00	human brain tissue	proposed	N/A
Molecular docking analysis of aminophylline binding targets	exploratory	depression	0.800	0.00	in silico molecular docking	proposed	N/A
Bioinformatics analysis and hub gene identification	exploratory	Alzheimer's disease	0.800	0.00	computational analysis of tran	proposed	N/A

Related Papers (5)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Inflammatory Processes in Alzheimer's Disease-Pathomechanism, Diagnosis and Trea [PMID:37047492]	Unknown	Int J Mol Sci	2023	0
Pathogenesis of Alzheimer's Disease. [PMID:36613544]	Unknown	Int J Mol Sci	2022	0
Alzheimer's disease. [PMID:31753135]	["Soria Lopez, Jose A", "Gonz\u00e1lez,	Handbook of clinical neurology	2019	0
Alzheimer's disease. [PMID:28872215]	["Lane, C A", "Hardy, J", "Schott, J M"]	European journal of neurology	2018	0
Current understanding of Alzheimer's disease diagnosis and treatment. [PMID:30135715]	["Weller, Jason", "Budson, Andrew"]	F1000Research	2018	0

Debates (12)

Multi-agent debates referencing this entity

Second debate: Microglial TREM2-SYK Pathway Enhancement

closed · Rounds: 4 · Score: 0.57 · 2026-04-28

Debate: LPCAT3-Mediated Lands Cycle Remodeling as the Primary Ferroptotic Primin

closed · Rounds: 4 · Score: 0.12 · 2026-04-27

Debate: ALOX15-Driven Enzymatic Ferroptosis in AD Oligodendrocytes via PUFA-PE P

closed · Rounds: 4 · Score: 0.42 · 2026-04-27

Debate: LPCAT3-Mediated Lands Cycle Amplification of Ferroptotic Vulnerability i

closed · Rounds: 4 · Score: 0.48 · 2026-04-27

Debate: ACSL4-Driven Ferroptotic Priming in Disease-Associated Oligodendrocytes

closed · Rounds: 4 · Score: 0.47 · 2026-04-27

Should '40 Hz Gamma Entrainment Gates ACSL4-Mediated Ferroptotic Priming to Sele

closed · Rounds: 4 · Score: 0.52 · 2026-04-27

Should 'ACSL4-Ferroptotic Priming in Stressed Oligodendrocytes Drives White Matt

closed · Rounds: 4 · Score: 0.72 · 2026-04-27

The debate raised conflicting views on whether myelin restoration would be benef

closed · Rounds: 4 · Score: 1.00 · 2026-04-20

This study identifies oligodendrocytes as drivers of neuroinflammation in PD, co

closed · Rounds: 4 · Score: 0.79 · 2026-04-13

What gene expression changes in the aging mouse brain predict neurodegenerative

closed · Rounds: 4 · Score: 0.95 · 2026-04-03

Related Research

Hypotheses and analyses mentioning OLIGODENDROCYTES in their description or question text

No additional research found