concept

OLIGODENDROCYTES

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about OLIGODENDROCYTES: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

900Connections

4Hypotheses

11Analyses

50Outgoing

50Incoming

Summary

OLIGODENDROCYTES is a concept in neurodegeneration research. Key relationships include: co discussed, expressed in, activates. Associated with CANCER, DEMENTIA, NEURODEGENERATION. Connected to 80 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	OLIGODENDROCYTES
Summary	Page for Aging Oligodendrocytes
Key Genes/Proteins	TAU, AMYLOID
Related Diseases	NEUROINFLAMMATION, NEURODEGENERATION, DEMYELINATION, AUTOPHAGY, APOPTOSIS
Linked Hypotheses	4 hypotheses

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    OLIGODENDROCYTES["<b>OLIGODENDROCYTES</b>"]
    OLIGODENDROCYTES -->|"produces"| myelin["myelin"]
    OLIGODENDROCYTES -->|"expressed in"| Prosaposin["Prosaposin"]
    OLIGODENDROCYTES -->|"activates"| NEUROINFLAMMATION["NEUROINFLAMMATION"]
    OLIGODENDROCYTES -->|"causes"| NEURODEGENERATION["NEURODEGENERATION"]
    OLIGODENDROCYTES -->|"activates"| neuroinflammation["neuroinflammation"]
    OLIGODENDROCYTES -->|"activates"| neurodegeneration["neurodegeneration"]
    OLIGODENDROCYTES -->|"secretes"| IL6["IL6"]
    OLIGODENDROCYTES -->|"causes"| PARKIN["PARKIN"]
    OLIGODENDROCYTES -->|"causes"| PARKINSON["PARKINSON"]
    OLIGODENDROCYTES -->|"causes"| PARKINSON_S["PARKINSON'S"]
    HSPA1A["HSPA1A"] -->|"expressed in"| OLIGODENDROCYTES
    Microglia["Microglia"] -->|"interacts"| OLIGODENDROCYTES
    OxPC["OxPC"] -->|"causes"| OLIGODENDROCYTES
    BIN1["BIN1"] -->|"expressed in"| OLIGODENDROCYTES
    GPR37["GPR37"] -->|"expressed in"| OLIGODENDROCYTES
    DOPAMINERGIC_NEURONS["DOPAMINERGIC_NEURONS"] -->|"interacts"| OLIGODENDROCYTES
    OXPCS["OXPCS"] -->|"inhibits"| OLIGODENDROCYTES
    OxPCs["OxPCs"] -->|"causes"| OLIGODENDROCYTES
    AQP4["AQP4"] -->|"activates"| OLIGODENDROCYTES
    ASTROCYTE["ASTROCYTE"] -->|"activates"| OLIGODENDROCYTES
    ASTROCYTES["ASTROCYTES"] -->|"activates"| OLIGODENDROCYTES
    COMPLEMENT["COMPLEMENT"] -->|"activates"| OLIGODENDROCYTES

Outgoing (223)

Target	Relation	Type	Str
neurons	interacts_with	cell_type	0.80
NEUROINFLAMMATION	activates	phenotype	0.72
NEURODEGENERATION	causes	phenotype	0.72
NEURODEGENERATION	activates	phenotype	0.72
DEMYELINATION	destabilizes	phenotype	0.70
AUTOPHAGY	inhibits	phenotype	0.70
APOPTOSIS	exacerbates	phenotype	0.70
WHITE MATTER	activates	brain_region	0.65
PERICYTE	impairs	cell_type	0.65
TAU	contributes_to	gene	0.65
AMYLOID	produces	protein	0.65
MICROGLIA	treats	cell_type	0.65
AXONAL DEGENERATION	causes	phenotype	0.65
CEREBELLUM	protects_against	brain_region	0.65
WHITE MATTER	causes	brain_region	0.65
LYSOSOMAL DYSFUNCTION	activates	phenotype	0.65
SENESCENCE	causes	phenotype	0.65
HIPPOCAMPUS	activates	brain_region	0.65
NEURODEGENERATION	interacts_with	disease	0.65
ENDOPLASMIC RETICULUM STRESS	interacts_with	phenotype	0.65
OXIDATIVE PHOSPHORYLATION	inhibits	pathway	0.65
PLP1	causes	gene	0.65
IL6	secretes	protein	0.64
PARKIN	causes	gene	0.60
PARKINSON	causes	disease	0.60
PARKINSON'S	causes	disease	0.60
PARKIN	activates	gene	0.60
PARKINSON	activates	disease	0.60
SUBSTANTIA NIGRA	activates	brain_region	0.60
PARKIN	expressed_in	gene	0.60
PARKINSON	expressed_in	disease	0.60
PARKINSON'S	expressed_in	disease	0.60
STROKE	expressed_in	disease	0.60
SYNAPTIC TRANSMISSION	regulates	biological_process	0.60
STING	contributes_to	gene	0.60
WHITE MATTER	associated_with	brain_region	0.60
T CELL	associated_with	cell_type	0.60
T CELL	expressed_in	cell_type	0.60
OLIG2	stabilizes	gene	0.60
MOTOR NEURONS	implicated_in	cell_type	0.55
NEURODEGENERATION	implicated_in	disease	0.55
PARKINSON	co_discussed	entity	0.50
PARKINSON'S	co_discussed	entity	0.50
SUBSTANTIA NIGRA	co_discussed	entity	0.50
STROKE	co_discussed	entity	0.50
PERICYTE	co_discussed	entity	0.50
PERICYTES	co_discussed	entity	0.50
PARKINSON'S DISEASE	associated_with	disease	0.50
PARKINSON	associated_with	disease	0.50
NEURODEGENERATION	associated_with	process	0.50

Incoming (677)

Source	Relation	Type	Str
NEURON	activates	cell_type	0.95
MICROGLIA	regulates	cell_type	0.95
NEURON	regulates	cell_type	0.95
OLIGODENDROCYTE	sensitizes_to	cell_type	0.65
MICROGLIA	mediates	cell_type	0.65
OLIGODENDROCYTE	mediates	cell_type	0.65
MICROGLIA	inhibits	cell_type	0.65
BIN1	causes	gene	0.65
GLUTAMATERGIC	expressed_in	cell_type	0.65
OLIGODENDROCYTE	regulates	cell_type	0.65
DEMENTIA	interacts_with	disease	0.65
DEMENTIA	activates	disease	0.65
DEMYELINATION	activates	process	0.65
NEURON	inhibits	cell_type	0.65
CORTEX	phosphorylates	brain_region	0.65
OLIGODENDROCYTE	transports	cell_type	0.65
MICROGLIA	contributes_to	cell_type	0.65
APOE	activates	gene	0.65
APOE2	activates	gene	0.65
APOE3	activates	gene	0.65
APOE4	activates	gene	0.65
ASTROCYTE	interacts_with	cell_type	0.65
NRF2	inhibits	gene	0.65
GPX4	activates	gene	0.65
SPINAL CORD	produces	brain_region	0.65
WNT SIGNALING	regulates	pathway	0.65
PERICYTE	regulates	cell_type	0.65
APOE	causes	gene	0.65
METFORMIN	activates	drug	0.65
MBP	produces	gene	0.65
APOPTOSIS	produces	phenotype	0.65
OLIGODENDROCYTE	produces	cell_type	0.65
OLIG2	produces	gene	0.65
GPR37	expressed_in	gene	0.64
DOPAMINERGIC_NEURONS	interacts_with	cell_type	0.64
OXPCS	inhibits	protein	0.64
AQP4	activates	gene	0.60
ASTROCYTE	activates	cell_type	0.60
ASTROCYTES	activates	cell_type	0.60
NEURODEGENERATION	causes	disease	0.60
OLIGODENDROCYTE	causes	cell_type	0.60
OLIGODENDROCYTE	associated_with	cell_type	0.60
OLIGODENDROCYTE	activates	cell_type	0.60
NEURON	promotes	cell_type	0.60
NEURODEGENERATION	protects_against	disease	0.60
OLIGODENDROCYTE	protects_against	cell_type	0.60
DOPAMINERGIC	interacts_with	cell_type	0.60
NEURON	interacts_with	cell_type	0.60
NEURONS	interacts_with	cell_type	0.60
OLIGODENDROCYTE	interacts_with	cell_type	0.60

Targeting Hypotheses (4)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
PDE4 Inhibition as Inflammatory Reset for PD Oligodendrocyte	0.576	neuroinflammation	How do oligodendrocytes initiate neuroin
ACSL4-Ferroptotic Priming in Stressed Oligodendrocytes Drive	0.512	Alzheimer's Disease	Cell type vulnerability in Alzheimers Di
ACSL4-Driven Ferroptotic Priming in Disease-Associated Oligo	0.493	Alzheimer's Disease	Cell type vulnerability in Alzheimers Di
ALOX15-Driven Enzymatic Ferroptosis in AD Oligodendrocytes v	0.491	Alzheimer's Disease	Cell type vulnerability in Alzheimers Di

Mentioning Analyses (11)

Scientific analyses that reference this entity

Related Papers (6)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year
Vitamin C inhibits ACSL4 to alleviate ferro-aging in primates. [PMID:41819088]	Liu L, Zheng Z, You W, Yang P, Wen Y et	Cell Metab	2026
[The Chinese medicine Gandouling attenuates brain injury in hepatolenticular deg [PMID:41946579]	Wu K, Wang N, Zhao D, Wei W, Zhang W et	Zhejiang Da Xue Xue Bao Yi Xue	2026
Vitamin C slows primate aging by targeting iron-driven lipid peroxidation. [PMID:41950897]	Yu PL, Xu CR	Cell Metab	2026
The IL-33/ST2 Signaling Axis Alleviates Splenic Injury in Severe Acute Pancreati [PMID:41954769]	Cui L, Xu N, Chen J, Bin C, Feng Y et al	Pancreas	2026
Fibroblast-Specific GPX4 Deletion Exacerbates IBD via Lipid Peroxidation. [PMID:41955120]	Zhang Y, Ying Y, Huang W, Rosenfeld ZA,	Am J Physiol Gastrointest Live	2026
Isorhamnetin-preconditioned MSC-derived exosomes restore ovarian function by inh [PMID:41947243]	Zhang Q, Yu J, Zheng Y, Jiang J, Zheng L	Stem Cell Res Ther	2026

OLIGODENDROCYTES

Understanding Entity Pages

Summary

Wiki Pages (21)

Aging Oligodendrocytes

cbs-psp-daily-action-plan

Personalized Treatment Plan — Atypical Parkinsonism (CBS/PSP)

Clinical Management Guide for CBS/PSP

Progressive Supranuclear Palsy (PSP)

Novel Therapy Index

Pathway Diagram

Outgoing (223)

Incoming (677)

Targeting Hypotheses (4)

Mentioning Analyses (11)

What specific molecular mechanisms link APOE4 to cholesterol dysregulation in ol

What molecular mechanisms enable microglia to neutralize OxPC-mediated neurodege

How do oligodendrocytes initiate neuroinflammation in PD when microglia are trad

What specific gene expression signatures in aging mouse white matter predict hum

Which cell types show the most significant expression changes for neurodegenerat

Cell type vulnerability in Alzheimers Disease (SEA-AD transcriptomic data)

Cell type vulnerability in Alzheimers Disease (SEA-AD transcriptomic data)

Cell type vulnerability in Alzheimer's Disease (SEA-AD data - v2)

Cell type vulnerability in Alzheimer's Disease (SEA-AD data - v2)

Cell type vulnerability in Alzheimers Disease (SEA-AD transcriptomic data)

Cell type vulnerability in Alzheimers Disease (SEA-AD transcriptomic data)

Related Papers (6)

OLIGODENDROCYTES

Understanding Entity Pages

Summary

Wiki Pages (21)

Aging Oligodendrocytes

cbs-psp-daily-action-plan

Personalized Treatment Plan — Atypical Parkinsonism (CBS/PSP)

Clinical Management Guide for CBS/PSP

Progressive Supranuclear Palsy (PSP)

Novel Therapy Index

Parkinson's Disease

Microglia CD8+ T Cell Recruitment -- Supplementary WW Content

primary-progressive-aphasia

calcium-dysregulation-comparison

Alpha-Synuclein Pathology

Corticobasal Degeneration (CBD)

Therapeutics

PI-2620 Tau PET in PSP

Section 162: Advanced Antioxidant and Redox Therapy in CBS/PSP

Neurons — Cell Type Hierarchy

neuroinflammation

GRIA3 Gene

NRF2 Oxidative Stress Pathway

Multiple System Atrophy

Alzheimer's Disease

Pathway Diagram

Outgoing (223)

Incoming (677)

Targeting Hypotheses (4)

Mentioning Analyses (11)

What specific molecular mechanisms link APOE4 to cholesterol dysregulation in ol

What molecular mechanisms enable microglia to neutralize OxPC-mediated neurodege

How do oligodendrocytes initiate neuroinflammation in PD when microglia are trad

What specific gene expression signatures in aging mouse white matter predict hum

Which cell types show the most significant expression changes for neurodegenerat

Cell type vulnerability in Alzheimers Disease (SEA-AD transcriptomic data)

Cell type vulnerability in Alzheimers Disease (SEA-AD transcriptomic data)

Cell type vulnerability in Alzheimer's Disease (SEA-AD data - v2)

Cell type vulnerability in Alzheimer's Disease (SEA-AD data - v2)

Cell type vulnerability in Alzheimers Disease (SEA-AD transcriptomic data)

Cell type vulnerability in Alzheimers Disease (SEA-AD transcriptomic data)

Related Papers (6)