| Gene Symbol | NEURODEGENERATION |
| Aliases | neurodegeneration |
| Amyloid biomarkers | Aβ42/40 ratio — reduced in Alzheimer's disease due to amyloid plaque deposition |
| Tau biomarkers | total tau (elevated in neuronal damage), phosphorylated tau (reflects tau pathology) |
| Neurodegeneration markers | NfL (neurofilament light chain), neurogranin (synaptic damage) |
| Inflammatory markers | IL-6, TNF-α, IL-1β — elevated in neuroinflammation[@shen2024] |
| Pre-symptomatic detection | Amyloid positivity can be identified 15-20 years before clinical onset |
| Prodromal Parkinson's disease | Alpha-synuclein seed amplification detects REM sleep behavior disorder converting to PD |
| Disease progression monitoring | NfL levels double every 2-3 years in aggressive disease variants |
| AD vs. FTD | Aβ42/t-tau ratio <0.5 suggests AD with 90% accuracy |
| PD vs. MSA vs. PSP | Alpha-synuclein conformation distinguishes synucleinopathies |
| ALS vs. mimics | NfL and pNfH levels above certain thresholds indicate ALS |
| Associated Diseases | Aging, Als, Alzheimer, Amyotrophic Lateral Sclerosis, Anxiety |
| Known Drugs/Compounds | CANAGLIFLOZIN, Cgmp, DPP-4 INHIBITORS, LITHIUM, MELATONIN, MEMANTINE |
| Interactions | 6-OHDA, ABCA1, ABCD1, ACE, ACE2, ACETYL-COA |
| KG Connections | 6186 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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