| Gene Symbol | SLC16A1 |
| Full Name | Solute Carrier Family 16 Member 1 |
| Aliases | MCT1, Monocarboxylate Transporter 1 |
| Chromosome | 1p13.3 |
| Protein Type | Transporter |
| Target Class | Transporter |
| Function | Transporter modulation — restoring MCT1/MCT4 balance to normalize astrocyte-neuron metabolic coupling |
| Mechanism of Action | Transporter modulation — restoring MCT1/MCT4 balance to normalize astrocyte-neuron metabolic coupling |
| Primary Expression | brain capillary endothelial cells forming the blood-brain barrier [7](https://pubmed |
| Druggability | Low (0.38) |
| Clinical Stage | Phase II |
| Molecular Weight | 54 kDa |
| Amino Acids | 500 aa |
| Pathways | Histone Modification, Wnt |
| UniProt ID | P53985 |
| NCBI Gene ID | 6566 |
| Ensembl ID | ENSG00000146411 |
| OMIM | 109580 |
| GeneCards | SLC16A1 |
| Human Protein Atlas | SLC16A1 |
| Associated Diseases | ALI, ALS, AMI, ARM, Aging |
| Known Drugs/Compounds | ATORVASTATIN, TEMOZOLOMIDE, statins |
| Interactions | PI3K, PRKAA2, HMOX1, CD47, PDIA6, Rb |
| SciDEX Target | View Target Profile (1 clinical trials) |
| SciDEX Hypotheses | Dynamic Lactate-Pyruvate Ratio as Therapeutic Stra Astrocyte MCT1/MCT4 Ratio Disruption with Metaboli |
| KG Connections | 390 knowledge graph edges |
| Databases | GeneCardsHPASTRING |