| Gene Symbol | Epigenetic |
| Non-invasive sampling | Blood, saliva, or easily accessible tissues |
| Dynamic nature | Reflect disease activity and treatment response |
| Early detection potential | Changes detectable before clinical symptoms |
| Disease specificity | Distinct methylation signatures for AD, PD, ALS, HD |
| microRNAs (miRNAs) | 18-25 nucleotide RNAs that target mRNA for degradation or translational repression |
| long non-coding RNAs (lncRNAs) | >200 nucleotide transcripts involved in chromatin remodeling and transcription regulation |
| circular RNAs (circRNAs) | Circularized RNAs that function as miRNA sponges, stable in blood and CSF |
| ANKI hypermethylation | Correlates with CSF p-Tau181 levels (AUC 0.79) |
| SIRPA hypermethylation | Associated with hippocampal atrophy rate |
| Multi-gene panels | Combined DMP analysis achieves AUC 0.85-0.88 for AD vs. controls |
| Epigenetic age acceleration | DNAm age 3-5 years older than chronological age in AD |
| Associated Diseases | Carcinoma |
| KG Connections | 2074 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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