| Gene Symbol | CDK5 |
| Protein Family | CMGC kinase group, CDK family |
| Protein Type | Serine/Threonine Kinase |
| Function | Cdk5 knockout mice die at birth with severe cortical layering defects due to failed neuronal migration. |
| Primary Expression | Cytoplasm, nucleus, synapses, growth cones, perinuclear region |
| Subcellular Localization | Cytoplasm, nucleus, synapses, growth cones, perinuclear region |
| Amino Acids | 291 aa |
| Pathways | Apoptosis, Autophagy, Checkpoint Inhibitor, Immune Checkpoint, Immune Response |
| GeneCards | CDK5 |
| Human Protein Atlas | CDK5 |
| Protein Name [@tarricone2001]
Cdk5 (Cyclin-Dependent Kinase 5) [@seo2017]
[@bhatt2023]
[@cheung2006]
Gene [@lopes2010]
CDK5 (7q36.1) [@tau]
[@taua]
[@gskb]
UniProt [@amyloidbeta]
Q00535 [@alzheimers]
[@parkinsons]
[@nflprotein]
PDB Structures [@excitotoxicity]
1H4L, 1UNL, 3O0G
Molecular Weight | ~33.3 kDa (291 amino acids) |
| Associated Diseases | ALS, Aging, Alzheimer, Alzheimer's disease, Ataxia |
| Known Drugs/Compounds | RESVERATROL, metformin, METFORMIN, N-ACETYLCYSTEINE, Protopanaxatriol |
| Interactions | LIS1, DAB1, PAFAH1B1, DRP1, MAPT, HSP90AA1 |
| KG Connections | 612 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |