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general 2,389 words KG: GLUTAMATE
Contents

glutamate

🔬 Protein Info
Gene SymbolGLUTAMATE
Associated DiseasesCOGNITIVE DECLINE, EPILEPSY, EXCITOTOXICITY, FERROPTOSIS, GLUTAMATE EXCITOTOXICITY, GLYCOLYSIS
Known Drugs/CompoundsKETAMINE
InteractionsAKT, AMPK, APOE, APP, BIN1, PARKIN
KG Connections610 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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Knowledge Graph

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🌐 Cross-references

Wikipedia

Related Hypotheses (71)

FOXO3-Longevity Pathway Epigenetic Reprogramming
Score: 0.63Astroglial Gap Junction Coordination via Connexin-43 Phospho
Score: 0.57Trans-Synaptic Adhesion Molecule Modulation
Score: 0.54Cryptic Exon Silencing Restoration
Score: 0.53Astrocytic Lactate Shuttle Enhancement for Grid Cell Bioener
Score: 0.53Vocal Cord Neuroplasticity Stimulation
Score: 0.52Microbiome-Derived Tryptophan Metabolite Neuroprotection
Score: 0.43Gamma entrainment therapy to restore hippocampal-cortical sy
Score: 0.95SASP-Mediated Complement Cascade Amplification
Score: 0.82Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.82Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79Competitive APOE4 Domain Stabilization Peptides
Score: 0.78Selective HDAC3 Inhibition with Cognitive Enhancement
Score: 0.78Transcriptional Autophagy-Lysosome Coupling
Score: 0.78Prefrontal sensory gating circuit restoration via PV interne
Score: 0.78APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.76SASP-Mediated Cholinergic Synapse Disruption
Score: 0.76Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.76Multi-Modal Stress Response Harmonization
Score: 0.76GFAP-Positive Reactive Astrocyte Subtype Delineation
Score: 0.75
← Prevpg 2/4Next →

Related Analyses (28)

SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas
neurodegeneration · completedRNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archivedSynaptic pruning by microglia in early AD
neurodegeneration · archivedMitochondrial transfer between astrocytes and neurons
neurodegeneration · archivedEpigenetic clocks and biological aging in neurodegeneration
neurodegeneration · archived

Related Experiments (8)

Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40Stress-induced depression model sleep architecture analysis
validation · proposed · Score: 0.90Electrophysiological analysis of mPFC-vlPAG synaptic transmi
exploratory · proposed · Score: 0.85Pathway analysis of aminophylline effects on neuronal signal
exploratory · proposed · Score: 0.70s:** - Dose-response studies showing therapeutic window with
falsification · proposed · Score: 0.40

See Also (5)

acetylcholine
general · KG edge: co_discussedadra2b Gene
gene · KG edge: expressed_inGPX4 Gene - Glutathione Peroxidase 4
gene · KG edge: co_discussedAlzheimer Indonesia
institution · KG edge: activatesPackard Center for ALS Research
institution · KG edge: associated_with

Knowledge Graph (12 edges)

GLUTAMATE associated_with EXCITOTOXICITY
MACROPHAGES activates GLUTAMATE
GLUTAMATE inhibits AXONS
GLUTAMATE causes EXCITOTOXICITY
FERROPTOSIS co_discussed GLUTAMATE
GLUTAMATE co_discussed GPX4
GLUTAMATE co_discussed MITOCHONDRIA
BRAINSTEM co_discussed GLUTAMATE
FOXO3 co_discussed GLUTAMATE
GLUTAMATE co_discussed OPTN

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