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general 2,389 words KG: GLUTAMATE
Contents

glutamate

🔬 Protein Info
Gene SymbolGLUTAMATE
Associated DiseasesCOGNITIVE DECLINE, EPILEPSY, EXCITOTOXICITY, FERROPTOSIS, GLUTAMATE EXCITOTOXICITY, GLYCOLYSIS
Known Drugs/CompoundsKETAMINE
InteractionsAKT, AMPK, APOE, APP, BIN1, PARKIN
KG Connections610 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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Knowledge Graph

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🌐 Cross-references

Wikipedia

Related Hypotheses (71)

APOE Isoform Expression Across Glial Subtypes
Score: 0.74Near-infrared light therapy stimulates COX4-dependent mitoch
Score: 0.74Interfacial Lipid Mimetics to Disrupt Domain Interaction
Score: 0.72Circadian-Synchronized LRP1 Pathway Activation
Score: 0.71Circadian Glymphatic Rescue Therapy (Melatonin-focused)
Score: 0.71Noradrenergic-Tau Propagation Blockade
Score: 0.71HDAC3-Selective Inhibition for Clock Reset
Score: 0.71Orexin-Microglia Modulation Therapy
Score: 0.71Mitochondrial-Nuclear Epigenetic Cross-Talk Restoration
Score: 0.70Reelin-Mediated Cytoskeletal Stabilization Protocol
Score: 0.69Cross-Seeding Prevention Strategy
Score: 0.69Chaperone-Mediated APOE4 Refolding Enhancement
Score: 0.68Astrocytic Connexin-43 Upregulation Enhances Neuroprotective
Score: 0.68Complement C1QA Spatial Gradient in Cortical Layers
Score: 0.68Astrocyte MCT1/MCT4 Ratio Disruption with Metabolic Uncoupli
Score: 0.67Aquaporin-4 Polarization Enhancement via TREK-1 Channel Modu
Score: 0.67Biorhythmic Interference via Controlled Sleep Oscillations
Score: 0.66Microbial Inflammasome Priming Prevention
Score: 0.65APOE-Mediated Synaptic Lipid Raft Stabilization
Score: 0.65Glycine-Rich Domain Competitive Inhibition
Score: 0.64
← Prevpg 3/4Next →

Related Analyses (28)

SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas
neurodegeneration · completedRNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archivedSynaptic pruning by microglia in early AD
neurodegeneration · archivedMitochondrial transfer between astrocytes and neurons
neurodegeneration · archivedEpigenetic clocks and biological aging in neurodegeneration
neurodegeneration · archived

Related Experiments (8)

Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40Stress-induced depression model sleep architecture analysis
validation · proposed · Score: 0.90Electrophysiological analysis of mPFC-vlPAG synaptic transmi
exploratory · proposed · Score: 0.85Pathway analysis of aminophylline effects on neuronal signal
exploratory · proposed · Score: 0.70s:** - Dose-response studies showing therapeutic window with
falsification · proposed · Score: 0.40

See Also (5)

acetylcholine
general · KG edge: co_discussedadra2b Gene
gene · KG edge: expressed_inGPX4 Gene - Glutathione Peroxidase 4
gene · KG edge: co_discussedAlzheimer Indonesia
institution · KG edge: activatesPackard Center for ALS Research
institution · KG edge: associated_with

Knowledge Graph (12 edges)

GLUTAMATE associated_with EXCITOTOXICITY
MACROPHAGES activates GLUTAMATE
GLUTAMATE inhibits AXONS
GLUTAMATE causes EXCITOTOXICITY
FERROPTOSIS co_discussed GLUTAMATE
GLUTAMATE co_discussed GPX4
GLUTAMATE co_discussed MITOCHONDRIA
BRAINSTEM co_discussed GLUTAMATE
FOXO3 co_discussed GLUTAMATE
GLUTAMATE co_discussed OPTN

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