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gene 4,449 words KG: GBA
Contents

GBA Gene

🧬 Gene Info
Gene SymbolGBA
Functionis a critical gene in the intersection of lysosomal storage disorders and neurodegenerative diseases.
Molecular Weight60 kDa
Amino Acids536 aa
PathwaysAmyloid, Autophagy, Autophagy-Lysosomal Pathway, Chaperone, Epigenetic
Ensembl IDENSG00000177628
GeneCardsGBA
Human Protein AtlasGBA
Associated DiseasesAD, Aging, ALI, Als, Alzheimer
Known Drugs/CompoundsAAV.GMU01_SS3-GBA1, glucosylceramide, NCGC00188758
InteractionsABCD3, ACHE, Actin, AD, AGING, ALPHA-SYNUCLEIN
SciDEX HypothesesGlucosylceramide accumulation nucleates alpha-synu
Freezing-of-Gait Prediction Algorithm Using GBA Mu
Adaptive Deep Brain Stimulation Targeting the Pedu (+2 more)
KG Connections1591 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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Knowledge Graph

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (23)

Autophagy-Lysosomal Pathway Dysfunction as a Unifying Proteo
Score: 0.82Lysosomal GBA1 Enhancement via Glucosylceramide Reduction
Score: 0.80GBA1/GCase restoration to reduce alpha-synuclein pathology i
Score: 0.76GBA1 Loss Triggers a TFEB-to-TFE3 Compensatory Switch in A9
Score: 0.75GBA1-Deficiency Disrupts Mitochondrial- Lysosomal Contact Si
Score: 0.75PD-Associated GWAS Variants in CTSO and CTSF Genes Create a
Score: 0.74Pharmacologic activation of GBA1 to reduce alpha-synuclein b
Score: 0.72Lysosomal Acidification Failure: Convergent GBA1/LAMP2A–medi
Score: 0.70Glucosylceramide Accumulation from GCase Deficiency Disrupts
Score: 0.70VPS35 Retromer Dysfunction Creates a GCase Trafficking Bottl
Score: 0.70Ribosome Stalling and Collision-Induced Translational Repres
Score: 0.62Glucosylceramide accumulation nucleates alpha-synuclein aggr
Score: 0.53Vagus Nerve as Anatomical Highway for Prion-Like α-Syn Propa
Score: 0.44Glucosylceramide-mediated feedback loop drives GBA-synuclein
Score: 0.38Lysosomal Membrane Stabilization as Upstream GBA Therapy
Score: 0.00Neuroinflammation Biomarker-Guided Immunomodulation for GBA
Score: 0.00Personalized DBS Programming Based on GBA Genotype-Specific
Score: 0.00Lipid Raft Disruptors with Membrane Fluidizers
Score: 0.00Engineered Extracellular Vesicle Therapy with Synthetic Biol
Score: 0.00Pharmacological Chaperone-Mediated Selective Autophagy
Score: 0.00
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Related Experiments (2)

Validate Mitochondria-Lysosome Contact Site Dysfunction in P
validation · proposed · Score: 0.40LRRK2/GBA Mutation Carrier Resilience — Why Some Carriers Ne
validation · completed · Score: 0.40

Knowledge Graph (12 edges)

CAT interacts_with GBA
OPTN interacts_with GBA
DNM1L interacts_with GBA
CANX interacts_with GBA
LGALS3 interacts_with GBA
CALCOCO2 interacts_with GBA
PEX3 interacts_with GBA
SQSTM1 interacts_with GBA
BCL2 interacts_with GBA
LMNA interacts_with GBA

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