gene 2,253 words KG: CHMP3 2026-03-27
kind:genesection:genestopic:alzheimerstopic:parkinsonsevidence:strong
Contents

CHMP3 — Charged Multivesicular Body Protein 3

🧬 Gene Info
Gene SymbolCHMP3
Full NameCharged Multivesicular Body Protein 3
Chromosome2p21
Functionis a core component of the Endosomal Sorting Complex Required for Transport-III (ESCRT-III)[@hanson2012].
Primary Expressionneurons and has been increasingly recognized for its critical role in maintaining neuronal protein homeostasis[@lee2019]
Molecular Weight~24 kDa
Amino Acids222 aa
PathwaysApoptosis, Complement, Exocytosis, Mitochondrial Function
UniProt IDQ9Y3E0
NCBI Gene ID25973
Ensembl IDENSG00000115159
OMIM609538
GeneCardsCHMP3
Human Protein AtlasCHMP3
Alternative NamesDID2, VPS24, CHMP24
Associated DiseasesAlzheimer's disease, Parkinson's disease
InteractionsEIF4G1, DISC1, IREB2, CHMP4B, CHMP6, ESCRT-III
KG Connections33 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (6)

APOE-Dependent Autophagy Restoration
Score: 0.61
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.51
Lysosomal Membrane Repair Enhancement
Score: 0.45
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.42
Liquid-Liquid Phase Separation Modifier Therapy
Score: 0.42

Related Analyses (7)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived

See Also (13)

Packard Center for ALS Research
institution · KG edge: regulates
Dementia Australia
institution · KG edge: regulates
Alzheimer Indonesia
institution · KG edge: regulates
PDE4C — Phosphodiesterase 4C
gene · KG edge: regulates
NOX1 Gene
gene · KG edge: regulates

Knowledge Graph (12 edges)

CHMP3 regulates PDE4C
CHMP3 regulates BAG1
CHMP3 regulates VTI1B
CHMP3 activates EIF4G1
CHMP3 regulates NOX1
CHMP3 regulates NGF
CHMP3 activates DISC1
CHMP3 regulates GALNT3
CHMP3 activates IREB2
CHMP3 interacts_with CHMP4B