EIF4G1

Understanding Entity Pages

This page aggregates everything SciDEX knows about EIF4G1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

EIF4G1 encodes eukaryotic translation initiation factor 4 gamma 1, with mutations linked to Parkinson's disease and ALS

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graph TD
    EIF4G1["<b>EIF4G1</b>"]
    Cancer{"Cancer"}
    EIF4G1 -->|"expressed in"| Cancer
    Tumor{"Tumor"}
    EIF4G1 -->|"expressed in"| Tumor
    Parkinson{"Parkinson"}
    EIF4G1 -->|"activates"| Parkinson
    Ms{"Ms"}
    EIF4G1 -->|"therapeutic target"| Ms
    Dementia{"Dementia"}
    EIF4G1 -->|"regulates"| Dementia
    Schizophrenia{"Schizophrenia"}
    EIF4G1 -->|"regulates"| Schizophrenia
    Alzheimer{"Alzheimer"}
    EIF4G1 -->|"regulates"| Alzheimer
    Multiple_Sclerosis{"Multiple Sclerosis"}
    EIF4G1 -->|"regulates"| Multiple_Sclerosis
    Als{"Als"}
    EIF4G1 -->|"regulates"| Als
    EIF4G1 -->|"regulates"| Cancer
    EIF4G1 -->|"regulates"| Ms
    ATG5["ATG5"]
    EIF4G1 -->|"interacts with"| ATG5
    CASP1["CASP1"]
    CASP1 -->|"interacts with"| EIF4G1
    MAPK8["MAPK8"]
    MAPK8 -->|"interacts with"| EIF4G1
    CD8["CD8"]
    CD8 -->|"expressed in"| EIF4G1
    IMMUNE_INFILTRATION["IMMUNE INFILTRATION"]
    IMMUNE_INFILTRATION -->|"expressed in"| EIF4G1
    CANCER["CANCER"]
    CANCER -->|"expressed in"| EIF4G1
    AUTOPHAGY["AUTOPHAGY"]
    AUTOPHAGY -->|"expressed in"| EIF4G1
    OXIDATIVE_STRESS["OXIDATIVE STRESS"]
    OXIDATIVE_STRESS -->|"expressed in"| EIF4G1
    PARKINSON_S_DISEASE["PARKINSON'S DISEASE"]
    PARKINSON_S_DISEASE -->|"therapeutic target"| EIF4G1
    ALPHA_SYNUCLEIN["ALPHA-SYNUCLEIN"]
    ALPHA_SYNUCLEIN -->|"therapeutic target"| EIF4G1
    ATXN2["ATXN2"]
    ATXN2 -->|"activates"| EIF4G1
    LRRK2["LRRK2"]
    LRRK2 -->|"activates"| EIF4G1
    ATP13A2["ATP13A2"]
    ATP13A2 -->|"activates"| EIF4G1
    style EIF4G1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0